MYOZ2 and LDB3

Number of citations of the paper that reports this interaction (PubMedID 11842093)
0

Data Source:
HPRD (in vivo, two hybrid)

		MYOZ2	LDB3
Description		myozenin 2	LIM domain binding 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Actin Cytoskeleton Sarcomere Z Disc	Stress Fiber Cytoplasm Cytoskeleton Adherens Junction Z Disc Pseudopodium Filamentous Actin Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Protein Binding Protein Phosphatase 2B Binding Telethonin Binding FATZ Binding	Actin Binding Protein Kinase C Binding Protein Binding Cytoskeletal Protein Binding Enzyme Binding Metal Ion Binding Muscle Alpha-actinin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Skeletal Muscle Fiber Adaptation Sarcomere Organization Negative Regulation Of Calcineurin-NFAT Signaling Cascade	Heart Development Actin Cytoskeleton Organization Sarcomere Organization Muscle Structure Development
Pathways
Drugs
Diseases			Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
GWAS		HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) PR interval ( 32439900) Refractive error ( 32231278)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		19 interacting genes: ACTN1 ACTN2 ACTN4 CRK DRICH1 ETF1 EWSR1 FLNC HSPB2 LDB3 MBLAC1 MKRN3 MYB PDLIM3 PPP3CA PPP3CB RBPMS WWOX ZDHHC17	7 interacting genes: ACTN2 ANKRD2 MYOZ1 MYOZ2 MYOZ3 TFCP2 TP53
Entrez ID		51778	11155
HPRD ID		05724	16172
Ensembl ID		ENSG00000172399	ENSG00000122367
Uniprot IDs		Q9NPC6	A0A0S2Z501 A0A0S2Z530 A0A8I5KV04 O75112 V5T7C5
PDB IDs			1RGW 4YDP
Enriched GO Terms of Interacting Partners?		Z Disc Cytoskeletal Protein Binding Muscle Cell Development Pseudopodium Actin Cytoskeleton Organization Actin Filament-based Process Actin Binding Cell Development Stress Fiber Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Transcription Coactivator Activity Actin Cytoskeleton Sarcomere Organization Calmodulin-dependent Protein Phosphatase Activity Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Cortical Actin Cytoskeleton Identical Protein Binding Positive Regulation Of Monoatomic Ion Transport Protein Serine/threonine Phosphatase Complex Platelet Alpha Granule Lumen Postsynaptic Actin Cytoskeleton Positive Regulation Of Calcium Ion Import Across Plasma Membrane Cytoskeleton Organization Enzyme Binding Actin Filament Binding Striated Muscle Cell Development Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Muscle Alpha-actinin Binding Regulation Of Monoatomic Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transport Positive Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Calcineurin-NFAT Signaling Cascade Actomyosin Structure Organization Regulation Of Monoatomic Ion Transmembrane Transport Glutamatergic Synapse Positive Regulation Of Calcium Ion Import Positive Regulation Of RNA Metabolic Process Focal Adhesion Assembly Calcineurin-mediated Signaling Calcium Ion Binding Skeletal Muscle Fiber Development Filamentous Actin Transmembrane Transporter Binding Muscle Structure Development Regulation Of Metal Ion Transport	FATZ Binding Telethonin Binding Z Disc Sarcomere Organization Skeletal Muscle Fiber Adaptation Actin Cytoskeleton Actin Binding Actomyosin Structure Organization Negative Regulation Of Calcineurin-NFAT Signaling Cascade Pseudopodium Negative Regulation Of Calcium-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Structural Constituent Of Muscle Molecular Condensate Scaffold Activity Regulation Of DNA-templated Transcription Sarcomere Regulation Of RNA Biosynthetic Process MRNA Transcription Actin Cytoskeleton Organization Negative Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Regulation Of RNA Metabolic Process Actin Filament Uncapping Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Negative Regulation Of Skeletal Muscle Tissue Regeneration Actin Filament-based Process Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Calcium-mediated Signaling Titin Z Domain Binding Oligodendrocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate PML Body Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Phospholipase C-activating Angiotensin-activated Signaling Pathway Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Oxidative Stress-induced Premature Senescence Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Cellular Response To Actinomycin D Striated Muscle Tissue Development Negative Regulation Of RNA Metabolic Process Microspike Assembly Positive Regulation Of Thymocyte Apoptotic Process
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