LDB3

Description		LIM domain binding 3
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GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytoskeleton Adherens Junction Z Disc Pseudopodium Filamentous Actin Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Actin Binding Protein Kinase C Binding Protein Binding Cytoskeletal Protein Binding Enzyme Binding Metal Ion Binding Muscle Alpha-actinin Binding
	Biological Process	Heart Development Actin Cytoskeleton Organization Sarcomere Organization Muscle Structure Development
Pathways
Drugs
Diseases		Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245)
Novel Interacting Genes		7 novel interacting genes: ACTN2 ANKRD2 MYOZ1 MYOZ2 MYOZ3 TFCP2 TP53
Interacting Genes		7 interacting genes: ACTN2 ANKRD2 MYOZ1 MYOZ2 MYOZ3 TFCP2 TP53
Entrez ID		11155
HPRD ID		16172
Ensembl ID		ENSG00000122367
Uniprot IDs		A0A0S2Z501 A0A0S2Z530 A0A8I5KV04 O75112 V5T7C5
PDB IDs		1RGW 4YDP
Enriched GO Terms of Interacting Partners?		FATZ Binding Telethonin Binding Z Disc Sarcomere Organization Skeletal Muscle Fiber Adaptation Actin Cytoskeleton Actin Binding Actomyosin Structure Organization Negative Regulation Of Calcineurin-NFAT Signaling Cascade Pseudopodium Negative Regulation Of Calcium-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Structural Constituent Of Muscle Molecular Condensate Scaffold Activity Regulation Of DNA-templated Transcription Sarcomere Regulation Of RNA Biosynthetic Process MRNA Transcription Actin Cytoskeleton Organization Negative Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Regulation Of RNA Metabolic Process Actin Filament Uncapping Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Negative Regulation Of Skeletal Muscle Tissue Regeneration Actin Filament-based Process Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Calcium-mediated Signaling Titin Z Domain Binding Oligodendrocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate PML Body Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Phospholipase C-activating Angiotensin-activated Signaling Pathway Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Oxidative Stress-induced Premature Senescence Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Cellular Response To Actinomycin D Striated Muscle Tissue Development Negative Regulation Of RNA Metabolic Process Microspike Assembly Positive Regulation Of Thymocyte Apoptotic Process
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