VPS33B and UVRAG

Number of citations of the paper that reports this interaction (PubMedID 18552835)
46

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		VPS33B	UVRAG
Description		VPS33B late endosome and lysosome associated	UV radiation resistance associated
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Clathrin-coated Vesicle HOPS Complex Platelet Alpha Granule Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane CORVET Complex Perinuclear Region Of Cytoplasm Recycling Endosome Vesicle Tethering Complex	Lytic Vacuole Autophagosome Membrane Chromosome, Centromeric Region Chromosome Cytoplasm Lysosome Endosome Early Endosome Late Endosome Autophagosome Endoplasmic Reticulum Centrosome Midbody Cytoplasmic Vesicle Protein-containing Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Phosphatidylinositol 3-kinase Complex, Class III Phagocytic Vesicle DNA-dependent Protein Kinase Complex
	Molecular Function	Protein Binding Protein-containing Complex Binding	SNARE Binding Protein Binding SH3 Domain Binding
	Biological Process	Intracellular Protein Transport Endosome Organization Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Peptidyl-lysine Hydroxylation Collagen Fibril Organization Melanosome Localization Lysosome Localization Collagen Metabolic Process Megakaryocyte Development Skin Morphogenesis Membrane Fusion Platelet Alpha Granule Organization Regulation Of Platelet Aggregation Phagosome-lysosome Fusion Autophagosome Maturation	DNA Repair Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Autophagy DNA Damage Response Spindle Organization Chromosome Segregation Centrosome Cycle Regulation Of Autophagy Vesicle-mediated Transport Regulation Of Cytokinesis Receptor Catabolic Process SNARE Complex Assembly Phosphatidylinositol-3-phosphate Biosynthetic Process Protein-containing Complex Organization Symbiont Entry Into Host Cell Maintenance Of Golgi Location Regulation Of Protein Serine/threonine Kinase Activity Multivesicular Body Sorting Pathway Autophagosome Maturation Double-strand Break Repair Via Classical Nonhomologous End Joining Positive Regulation Of Autophagosome Maturation
Pathways		Prevention of phagosomal-lysosomal fusion SARS-CoV-2 modulates autophagy	Macroautophagy Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex SARS-CoV-2 modulates autophagy
Drugs
Diseases		Arthrogryposis, renal dysfunction, and cholestasis; ARC syndrome
GWAS		Chronic kidney disease ( 30226566) Coronary artery disease ( 30402224) Feeling hurt ( 29500382) Hypertension ( 30226566) Ischemic stroke ( 29930801) Myocardial infarction ( 30226566) Red cell distribution width ( 32888494)	Asthma ( 31619474) HDL cholesterol ( 30275531) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Mean spheric corpuscular volume ( 32888494) Stroke ( 32693751) Thumb osteoarthritis severity (hand Klsum) ( 33055079)
Interacting Genes		6 interacting genes: APP MAP3K20 MAPK8IP2 TNIP1 UVRAG VIPAS39	11 interacting genes: CSNK1A1 ITCH MTOR NEDD4 OS9 VPS11 VPS16 VPS18 VPS33B YAP1 ZRANB1
Entrez ID		26276	7405
HPRD ID		10541	03929
Ensembl ID		ENSG00000184056	ENSG00000198382
Uniprot IDs		A0A0S2Z577 B7Z1N4 F5H008 Q9H267	Q9P2Y5
PDB IDs			7BL1
Enriched GO Terms of Interacting Partners?		Protein-containing Complex Organization Mating Behavior Early Endosome Modulation Of Excitatory Postsynaptic Potential Reproductive Behavior Autophagosome Maturation Regulation Of Stress-activated Protein Kinase Signaling Cascade Protein Kinase Activator Activity JNK Cascade Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Lytic Vacuole Positive Regulation Of Mitotic DNA Damage Checkpoint Protein-containing Complex Assembly Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Recycling Endosome Response To Stress Endosome To Plasma Membrane Transport Vesicle Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Positive Regulation Of Endothelin Production Growth Cone Filopodium Defense Response Lipoprotein Particle Regulation Of Cellular Response To Stress Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Regulation Of Nervous System Process Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Cell Communication Regulation Of MAPK Cascade Chromosome Segregation Protein-containing Complex Disassembly Maintenance Of Golgi Location Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of JNK Cascade Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Learning Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling	CORVET Complex HOPS Complex Vacuole Organization Vesicle Tethering Complex Lysosomal Transport Vacuolar Transport Endosome To Lysosome Transport Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Positive Regulation Of Protein Catabolic Process Catabolic Process Clathrin-coated Vesicle Vesicle Fusion Intracellular Protein Transport Organelle Membrane Fusion Endosome Membrane Protein Modification Process Early Endosome Organelle Fusion Regulation Of Protein Catabolic Process Lysosomal Membrane Late Endosome Membrane Late Endosome Membrane Fusion Regulation Of Protein-containing Complex Assembly Protein Metabolic Process Post-translational Protein Modification Cytoplasmic Vesicle Negative Regulation Of Signal Transduction Lysosome Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Autophagosome Endosome Organization Regulation Of Cellular Component Organization Protein Transport Protein Ubiquitination Autophagosome Assembly Autophagy Autophagosome Organization Vesicle-mediated Transport Vesicle Organization Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Proteolysis Involved In Protein Catabolic Process Proteolysis Intracellular Transport Protein Modification By Small Protein Conjugation
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