RAPGEF6 and RAP2A

Number of citations of the paper that reports this interaction (PubMedID 11524421)
0

Data Source:
HPRD (in vitro, in vivo)

		RAPGEF6	RAP2A
Description		Rap guanine nucleotide exchange factor 6	RAP2A, member of RAS oncogene family
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GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Membrane Apical Plasma Membrane Endocytic Vesicle	Lysosome Endosome Golgi Apparatus Cytosol Plasma Membrane Endomembrane System Membrane Midbody Cytoplasmic Vesicle Membrane Lamellipodium Membrane Endolysosome Cell Projection Synapse Recycling Endosome Recycling Endosome Membrane Synaptic Membrane Bounding Membrane Of Organelle Schaffer Collateral - CA1 Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP-dependent Protein Binding Small GTPase Binding Phosphatidic Acid Binding	Nucleotide Binding Magnesium Ion Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Microvillus Assembly Regulation Of GTPase Activity Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Microvillus Assembly	Signal Transduction Intracellular Protein Localization Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Rap Protein Signal Transduction Establishment Of Protein Localization Regulation Of JNK Cascade Regulation Of Dendrite Morphogenesis Regulation Of Synapse Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Microvillus Assembly
Pathways
Drugs			Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Alzheimer's disease in APOE e4- carriers ( 25778476) Asthma ( 32296059) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diisocyanate-induced asthma ( 25918132) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Perceived unattractiveness to mosquitoes ( 28199695) Subcortical volume (MOSTest) ( 32665545) Subjective well-being ( 27089181) Ulcerative colitis ( 28067908)	Gut microbiota (bacterial taxa) ( 27723756) Peripheral artery disease ( 26488411)
Interacting Genes		9 interacting genes: ABCA1 JADE2 LINC00839 MRAS NEDD4 PTPN13 RAP1A RAP2A YWHAG	34 interacting genes: ACVR1 AFDN ARHGAP29 BMPR1B CDK4 EEF1A1 ENSA FKBP2 FNTB FTL GABARAPL2 GRIN1 GRIN2D IRS2 MAP4K4 NEDD4 PLG RAB40B RAF1 RALGDS RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASIP1 RASSF5 RGS14 RRP9 RUNDC3A SERPINA1 SMAD1 TGFBR1 TM7SF2 TNIK
Entrez ID		51735	5911
HPRD ID		11483	01547
Ensembl ID		ENSG00000158987	ENSG00000125249
Uniprot IDs		B2RTU6 Q8TEU7	P10114
PDB IDs		2D93 3LNY	1KAO 2RAP 3RAP
Enriched GO Terms of Interacting Partners?		GDP Binding G Protein Activity Rap Protein Signal Transduction Regulation Of Cellular Component Organization Regulation Of Intracellular Signal Transduction Sphingolipid Floppase Activity Regulation Of Developmental Process Protein Localization To Lysosome Regulation Of Dendrite Morphogenesis Regulation Of Synapse Organization Formation Of Structure Involved In A Symbiotic Process Regulation Of Cell Junction Assembly GTPase Activity Small GTPase-mediated Signal Transduction Response To Vitamin B3 Intracellular Protein Localization Positive Regulation Of High-density Lipoprotein Particle Assembly Apolipoprotein A-I Receptor Activity Phagocytic Vesicle Protein Localization To Vacuole Channel Inhibitor Activity Intracellular Signal Transduction Regulation Of Dendrite Development Negative Regulation Of Excitatory Synapse Assembly Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Response To Antineoplastic Agent GTP Binding Regulation Of Neuron Projection Development Negative Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Regulation Of High-density Lipoprotein Particle Assembly Phosphothreonine Residue Binding Protein Kinase C Inhibitor Activity Negative Regulation Of Phosphorylation Phosphatidylserine Floppase Activity Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Extracellular Exosome Apolipoprotein A-I-mediated Signaling Pathway Regulation Of Cell Communication Floppase Activity Sphingolipid Translocation Establishment Of Protein Localization Lipoprotein Biosynthetic Process Phosphatidylcholine Floppase Activity Signal Release Apolipoprotein A-I Binding Regulation Of Signaling Phosphoserine Residue Binding Nuclear Receptor-mediated Corticosteroid Signaling Pathway	Intracellular Signaling Cassette Signal Transduction Transforming Growth Factor Beta Receptor Activity, Type I Intracellular Signal Transduction Ras Protein Signal Transduction Small GTPase-mediated Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling GTPase Regulator Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Microvillus Assembly Protein Kinase Activity Establishment Of Endothelial Barrier Activin Receptor Complex Activin Receptor Activity, Type I NMDA Glutamate Receptor Activity Glutamate Binding Endothelial Cell Development Guanyl-nucleotide Exchange Factor Activity BMP Receptor Activity Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition SMAD Binding NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Positive Regulation Of Signal Transduction Kinase Activity Potassium Channel Inhibitor Activity Excitatory Chemical Synaptic Transmission Regulation Of Microvillus Assembly Activin Binding Cellular Response To Growth Factor Stimulus Enzyme-linked Receptor Protein Signaling Pathway Plasma Membrane Regulation Of Type B Pancreatic Cell Proliferation Regulation Of Intracellular Signal Transduction Protein Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction Nucleotide Binding Regulation Of Insulin Secretion Response To Growth Factor Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Osteoblast Differentiation Regulation Of Cartilage Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway I-SMAD Binding Positive Regulation Of Cellular Component Biogenesis
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