RAPGEF6

Description		Rap guanine nucleotide exchange factor 6
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GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Membrane Apical Plasma Membrane Endocytic Vesicle
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP-dependent Protein Binding Small GTPase Binding Phosphatidic Acid Binding
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Microvillus Assembly Regulation Of GTPase Activity Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Microvillus Assembly
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease in APOE e4- carriers ( 25778476) Asthma ( 32296059) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diisocyanate-induced asthma ( 25918132) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Perceived unattractiveness to mosquitoes ( 28199695) Subcortical volume (MOSTest) ( 32665545) Subjective well-being ( 27089181) Ulcerative colitis ( 28067908)
Novel Interacting Genes		9 novel interacting genes: ABCA1 JADE2 LINC00839 MRAS NEDD4 PTPN13 RAP1A RAP2A YWHAG
Interacting Genes		9 interacting genes: ABCA1 JADE2 LINC00839 MRAS NEDD4 PTPN13 RAP1A RAP2A YWHAG
Entrez ID		51735
HPRD ID		11483
Ensembl ID		ENSG00000158987
Uniprot IDs		B2RTU6 Q8TEU7
PDB IDs		2D93 3LNY
Enriched GO Terms of Interacting Partners?		GDP Binding G Protein Activity Rap Protein Signal Transduction Regulation Of Cellular Component Organization Regulation Of Intracellular Signal Transduction Sphingolipid Floppase Activity Regulation Of Developmental Process Protein Localization To Lysosome Regulation Of Dendrite Morphogenesis Regulation Of Synapse Organization Formation Of Structure Involved In A Symbiotic Process Regulation Of Cell Junction Assembly GTPase Activity Small GTPase-mediated Signal Transduction Response To Vitamin B3 Intracellular Protein Localization Positive Regulation Of High-density Lipoprotein Particle Assembly Apolipoprotein A-I Receptor Activity Phagocytic Vesicle Protein Localization To Vacuole Channel Inhibitor Activity Intracellular Signal Transduction Regulation Of Dendrite Development Negative Regulation Of Excitatory Synapse Assembly Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Response To Antineoplastic Agent GTP Binding Regulation Of Neuron Projection Development Negative Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Regulation Of High-density Lipoprotein Particle Assembly Phosphothreonine Residue Binding Protein Kinase C Inhibitor Activity Negative Regulation Of Phosphorylation Phosphatidylserine Floppase Activity Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Extracellular Exosome Apolipoprotein A-I-mediated Signaling Pathway Regulation Of Cell Communication Floppase Activity Sphingolipid Translocation Establishment Of Protein Localization Lipoprotein Biosynthetic Process Phosphatidylcholine Floppase Activity Signal Release Apolipoprotein A-I Binding Regulation Of Signaling Phosphoserine Residue Binding Nuclear Receptor-mediated Corticosteroid Signaling Pathway
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