RAB23 and ARFGAP1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RAB23	ARFGAP1
Description		RAB23, member RAS oncogene family	ARF GTPase activating protein 1
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GO Annotations	Cellular Component	Cytoplasm Endosome Autophagosome Centrosome Cytosol Plasma Membrane Cilium Endosome Membrane Endomembrane System Membrane Cell Junction Phagocytic Vesicle Membrane Cytoplasmic Vesicle Ciliary Basal Body Phagocytic Vesicle	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Synapse
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Autophagosome Assembly Intracellular Protein Transport Cellular Defense Response Anatomical Structure Morphogenesis Protein Transport Negative Regulation Of Protein Import Into Nucleus GTP Metabolic Process System Development Cilium Assembly Craniofacial Suture Morphogenesis	Protein Transport Vesicle-mediated Transport Regulation Of Endocytosis Regulation Of ARF Protein Signal Transduction
Pathways		RAB geranylgeranylation	XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Clathrin-mediated endocytosis
Drugs
Diseases		Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS		Systemic lupus erythematosus ( 28714469)
Interacting Genes		2 interacting genes: ARFGAP1 CREB3	40 interacting genes: AGTR1 APOB APOC3 APOE APP ARF1 ASB10 COPA COPS5 CRYAA CSNK1D CYTH2 FOS GABARAPL1 GABARAPL2 GGCX GRN HRAS KDELR1 KRTAP10-9 KRTAP3-2 KRTAP9-2 LRRK2 MAP1LC3B MED27 PRKACB RAB23 RABGAP1L RASIP1 REEP5 RFC3 RGS2 RPL11 SLC25A21-AS1 SLC6A1 SMN1 SNCA TK1 TMED2 TRIM23
Entrez ID		51715	55738
HPRD ID		05850	06443
Ensembl ID		ENSG00000112210	ENSG00000101199
Uniprot IDs		Q9ULC3	Q53F62 Q8N6T3
PDB IDs		8YIM 8YL3 8YNR 8YO0 8YP0	3DWD 3O47
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Deacetylase Activity CCR1 Chemokine Receptor Binding Release From Viral Latency Golgi Membrane CAMP Response Element Binding Protein Binding Induction Of Positive Chemotaxis Positive Regulation Of Monocyte Chemotaxis Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Positive Chemotaxis Regulation Of ARF Protein Signal Transduction	Intermediate-density Lipoprotein Particle Protein-containing Complex Organization Phospholipid Binding Vesicle-mediated Transport Very-low-density Lipoprotein Particle Golgi Apparatus Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Protein-containing Complex Assembly Lipoprotein Metabolic Process Plasma Lipoprotein Particle Remodeling Cellular Response To Nitrogen Starvation Protein-containing Complex Remodeling Cellular Component Assembly Regulation Of Proteolysis Cytoplasmic Vesicle Beta-tubulin Binding Vacuole Organization Chylomicron Phosphatidylethanolamine Binding Low-density Lipoprotein Particle Chylomicron Remnant Negative Regulation Of Transport Locomotory Exploration Behavior Lipoprotein Particle Low-density Lipoprotein Particle Remodeling COPI-coated Vesicle Membrane Endocytosis Regulation Of Small Molecule Metabolic Process Regulation Of Neuronal Synaptic Plasticity Import Into Cell Cytosol Golgi Membrane Growth Cone Establishment Of Protein Localization Regulation Of Protein Catabolic Process Protein Transport Establishment Of Localization In Cell Cellular Response To Nutrient Levels Low-density Lipoprotein Particle Receptor Binding Regulation Of Long-term Neuronal Synaptic Plasticity Astrocyte Activation Involved In Immune Response Plasma Lipoprotein Particle Clearance Autophagosome Neutral Lipid Metabolic Process Cholesterol Efflux Microglial Cell Activation Positive Regulation Of Inflammatory Response Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance
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