PPIL1 and THOC5

Number of citations of the paper that reports this interaction (PubMedID 22365833)
0

Data Source:
BioGRID (two hybrid, two hybrid)

		PPIL1	THOC5
Description		peptidylprolyl isomerase like 1	THO complex subunit 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Isomerase Activity Disordered Domain Specific Binding	RNA Binding MRNA Binding Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Protein Peptidyl-prolyl Isomerization MRNA Processing Protein Folding RNA Splicing Embryonic Brain Development	MRNA Processing MRNA Export From Nucleus RNA Splicing Cell Differentiation Monocyte Differentiation MRNA Transport Primitive Hemopoiesis
Pathways		mRNA Splicing - Major Pathway	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination Signaling by CSF1 (M-CSF) in myeloid cells
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Blood protein levels ( 30072576) Heart rate ( 28610988) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate variability traits (pvRSA/HF) ( 28613276) Heart rate variability traits (RMSSD) ( 28613276) Heart rate variability traits (SDNN) ( 28613276) Resting heart rate ( 27798624) Weight ( 28552196)	Apolipoprotein A1 levels ( 32203549) Carotid atherosclerosis in HIV infection ( 20009918) HDL cholesterol levels ( 32203549) Lipid traits ( 24023261)
Interacting Genes		25 interacting genes: COL17A1 CPSF6 DDIT4L GADD45G HNRNPA1 HNRNPUL1 KPRP LHX2 LNX2 N4BP2L2 POU6F2 PPP1R8 PRR22 PRR35 RBM42 RIMBP3 SF3B3 SNW1 SPDYE4 SRPK1 SRPK2 TCF4 THOC5 UFL1 WDR77	11 interacting genes: CSF1R CSNK2A1 HSPB1 LIG4 LSM3 NXF1 OXTR PPIL1 PRKCA THOC7 ZNF830
Entrez ID		51645	8563
HPRD ID		03194	16650
Ensembl ID		ENSG00000137168	ENSG00000100296
Uniprot IDs		Q9Y3C6	Q13769
PDB IDs		1XWN 2K7N 2X7K 5MQF 5XJC 5YZG 5Z56 5Z57 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM 7QTT 7W59 7W5A 7W5B 8C6J 8CH6 8I0S 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD	7APK 7ZNK 7ZNL
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Splicing Regulation Of RNA Splicing MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing RNA Processing Spliceosomal Complex Regulation Of MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Spliceosomal Complex Assembly Nucleic Acid Metabolic Process RNA Binding Protein-RNA Complex Assembly Catalytic Step 2 Spliceosome Nuclear Speck Nucleobase-containing Compound Metabolic Process Nucleus MRNA Binding Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Viral Genome Replication Cell Differentiation Ribonuclease E Activity Exon-exon Junction Complex Binding UFM1 Ligase Activity Oocyte Axis Specification Regulation Of RNA Metabolic Process Protein-containing Complex Assembly Positive Regulation Of RNA Splicing Negative Regulation Of Viral Genome Replication	Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Double-strand Break Repair Via Classical Nonhomologous End Joining MRNA Metabolic Process Transcription Export Complex Nucleoplasm RNA Splicing Regulation Of Programmed Cell Death Regulation Of Apoptotic Process MRNA Processing Spliceosomal Complex Regulation Of Bone Resorption Protein Folding Regulation Of Bone Remodeling Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Protein Kinase C Signaling Establishment Of Integrated Proviral Latency Oxytocin Receptor Activity Nucleic Acid Metabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration MRNA Export From Nucleus Positive Regulation Of Cell Population Proliferation CSF1-CSF1R Complex Positive Regulation Of Multicellular Organismal Process Macrophage Colony-stimulating Factor Receptor Activity Regulation Of Tissue Remodeling Macrophage Colony-stimulating Factor Signaling Pathway Regulation Of Translational Initiation Nucleobase-containing Compound Metabolic Process Protein Kinase CK2 Complex RNA Metabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Translation DNA Damage Checkpoint Signaling Protein Kinase C Inhibitor Activity Positive Regulation Of Endothelial Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration DNA Ligase (ATP) Activity DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination Establishment Of Viral Latency DNA Ligase Activity DN2 Thymocyte Differentiation Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex Protein Kinase C Signaling
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