THOC5 and OXTR

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		THOC5	OXTR
Description		THO complex subunit 5	oxytocin receptor
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GO Annotations	Cellular Component	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm	Plasma Membrane Membrane
	Molecular Function	RNA Binding MRNA Binding Protein Binding	G Protein-coupled Receptor Activity Oxytocin Receptor Activity Vasopressin Receptor Activity
	Biological Process	MRNA Processing MRNA Export From Nucleus RNA Splicing Cell Differentiation Monocyte Differentiation MRNA Transport Primitive Hemopoiesis	Regulation Of Systemic Arterial Blood Pressure By Vasopressin System Process Muscle Contraction Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Female Pregnancy Lactation Cellular Response To Hormone Stimulus Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Maternal Process Involved In Parturition Regulation Of Biological Quality Positive Regulation Of Cold-induced Thermogenesis
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination Signaling by CSF1 (M-CSF) in myeloid cells	Vasopressin-like receptors G alpha (q) signalling events
Drugs			Vasopressin Oxytocin Carbetocin Atosiban Relcovaptan
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Carotid atherosclerosis in HIV infection ( 20009918) HDL cholesterol levels ( 32203549) Lipid traits ( 24023261)	Caudate activity during reward ( 28927378) Chronotype ( 30696823) Depression and alcohol dependence ( 22064162) Liver fibrosis severity in HIV/hepatitis C co-infection ( 27339598) Morning person ( 30696823)
Interacting Genes		11 interacting genes: CSF1R CSNK2A1 HSPB1 LIG4 LSM3 NXF1 OXTR PPIL1 PRKCA THOC7 ZNF830	18 interacting genes: ALAS1 ARRB2 ASH1L AVP CD81 CYFIP2 EMC10 FSCN1 GPRASP1 LCNL1 MVB12A OXT PSMA7 SIRT2 THOC5 TMEM161A TSPAN7 YIPF3
Entrez ID		8563	5021
HPRD ID		16650	01328
Ensembl ID		ENSG00000100296	ENSG00000180914
Uniprot IDs		Q13769	B2R9L7 P30559
PDB IDs		7APK 7ZNK 7ZNL	6TPK 7QVM 7RYC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Double-strand Break Repair Via Classical Nonhomologous End Joining MRNA Metabolic Process Transcription Export Complex Nucleoplasm RNA Splicing Regulation Of Programmed Cell Death Regulation Of Apoptotic Process MRNA Processing Spliceosomal Complex Regulation Of Bone Resorption Protein Folding Regulation Of Bone Remodeling Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Protein Kinase C Signaling Establishment Of Integrated Proviral Latency Oxytocin Receptor Activity Nucleic Acid Metabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration MRNA Export From Nucleus Positive Regulation Of Cell Population Proliferation CSF1-CSF1R Complex Positive Regulation Of Multicellular Organismal Process Macrophage Colony-stimulating Factor Receptor Activity Regulation Of Tissue Remodeling Macrophage Colony-stimulating Factor Signaling Pathway Regulation Of Translational Initiation Nucleobase-containing Compound Metabolic Process Protein Kinase CK2 Complex RNA Metabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Translation DNA Damage Checkpoint Signaling Protein Kinase C Inhibitor Activity Positive Regulation Of Endothelial Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration DNA Ligase (ATP) Activity DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination Establishment Of Viral Latency DNA Ligase Activity DN2 Thymocyte Differentiation Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex Protein Kinase C Signaling	Neurohypophyseal Hormone Activity Maternal Aggressive Behavior Regulation Of Female Receptivity Female Mating Behavior Aggressive Behavior Maternal Behavior Grooming Behavior Parental Behavior Receptor Catabolic Process Mating Behavior Neuronal Dense Core Vesicle Positive Regulation Of Fatty Acid Biosynthetic Process Neuropeptide Hormone Activity Positive Regulation Of Blood Pressure Regulation Of Fatty Acid Biosynthetic Process Response To Electrical Stimulus Reproductive Behavior V1B Vasopressin Receptor Binding Positive Regulation Of Fatty Acid Metabolic Process Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Positive Regulation Of Hindgut Contraction Oxytocin Receptor Binding Receptor Metabolic Process Negative Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Caloric Restriction Tarsal Gland Development Uterine Gland Development
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