CXXC5 and KCNJ6

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		CXXC5	KCNJ6
Description		CXXC finger protein 5	potassium inwardly rectifying channel subfamily J member 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Golgi Apparatus Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex
	Molecular Function	DNA Binding Zinc Ion Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding DNA-binding Transcription Factor Binding	Inward Rectifier Potassium Channel Activity Protein Binding G-protein Activated Inward Rectifier Potassium Channel Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Generation Of Precursor Metabolites And Energy	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways		Estrogen-dependent gene expression	Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs			Ethanol Halothane Ifenprodil Isavuconazole
Diseases
GWAS		Adult body size ( 32376654) Appendicular lean mass ( 33097823) Body mass index ( 25673413) Hip circumference adjusted for BMI ( 34021172) Ovarian cancer ( 30557369) Refractive error ( 32231278)	Body size at age 10 ( 32376654) Clostridioides difficle infection ( 33841421) Electroencephalographic traits in alcoholism ( 22554406) Response to placebo treatment in childhood asthma (FVC change) ( 31557306) Rosacea symptom severity ( 29771307)
Interacting Genes		14 interacting genes: ATM DSCAM DSCR9 HUNK KCNJ6 RCAN1 RSPH1 SKIL SMAD3 SMAD5 SMAD7 SMAD9 UBASH3A VDR	71 interacting genes: ADRB2 AIG1 APOD BCL2L2 BET1 BIRC5 C14orf180 CMAS CMTM5 CNPY3 COL4A5 CXXC5 DLG1 DRD2 EDDM3B ERG28 FAM20B FIS1 FUNDC2 FXYD6 GABBR1 GIPC1 HMOX2 ICMT ITGAM KCNJ3 KCNJ9 LEPROTL1 LPAR3 LPCAT2 MAP1S MIP MYO15B NINJ2 ORMDL2 PEX11G PEX16 PICK1 PLLP PMP22 PNLIPRP1 PTPRD RPRM RPS6KA2 RTP2 SCAMP4 SCARF1 SCD SERTM1 STATH STRIT1 SYT3 THSD7B TM6SF2 TMEM107 TMEM120B TMEM203 TMEM208 TMEM218 TMPPE TNFRSF10C TSPO2 UBIAD1 UNC50 UPK1B VSTM1 XIAP YIPF1 YIPF6 ZBTB38 ZDHHC24
Entrez ID		51523	3763
HPRD ID		13105	02929
Ensembl ID		ENSG00000171604	ENSG00000157542
Uniprot IDs		Q7LFL8	P48051
PDB IDs		5W9S
Enriched GO Terms of Interacting Partners?		Heteromeric SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction SMAD Protein Complex Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription Regulator Complex Intracellular Signal Transduction Response To Growth Factor Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Cellular Developmental Process Tissue Development DEAD/H-box RNA Helicase Binding Kidney Epithelium Development Positive Regulation Of Cell Differentiation Cellular Response To Growth Factor Stimulus Lens Fiber Cell Differentiation Regulation Of Cell Differentiation Regulation Of Ossification Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Osteoblast Differentiation Striated Muscle Tissue Development Muscle Tissue Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cartilage Development Signal Transduction Positive Regulation Of Developmental Process Cell-cell Junction Organization Cell Junction Organization Intracellular Signaling Cassette Germ Cell Development Cell Development Developmental Process Involved In Reproduction Negative Regulation Of Signal Transduction Positive Regulation Of Bone Mineralization Negative Regulation Of Ossification Somitogenesis Negative Regulation Of Signaling Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Communication Anatomical Structure Morphogenesis Negative Regulation Of Transcription By RNA Polymerase II Tube Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Lung Blood Pressure Positive Regulation Of Biomineral Tissue Development	Membrane Presynaptic Membrane Trans-synaptic Signaling Synaptic Signaling Endoplasmic Reticulum Membrane Protein Binding Endoplasmic Reticulum Chemical Synaptic Transmission Negative Regulation Of Dopamine Secretion G-protein Activated Inward Rectifier Potassium Channel Activity Compact Myelin Inward Rectifier Potassium Channel Complex Regulation Of Sodium Ion Transport Protein Targeting Regulation Of Presynaptic Membrane Potential Regulation Of Monoatomic Ion Transport Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Golgi Trans Cisterna Negative Regulation Of Synaptic Transmission
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