ISYNA1 and GATAD2A

		ISYNA1	GATAD2A
Description		inositol-3-phosphate synthase 1	GATA zinc finger domain containing 2A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm Chromosome NuRD Complex Nuclear Speck
	Molecular Function	Inositol-3-phosphate Synthase Activity Protein Binding Isomerase Activity	Protein Binding Zinc Ion Binding Protein-macromolecule Adaptor Activity Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Inositol Biosynthetic Process Lipid Metabolic Process Phospholipid Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of Stem Cell Differentiation
Pathways		Synthesis of IP2, IP, and Ins in the cytosol	HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs		2-Deoxy-D-Glucitol 6-(E)-Vinylhomophosphonate 2-Deoxy-Glucitol-6-Phosphate Glycerin
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Breast cancer ( 23535729) Heel bone mineral density ( 30598549)	Appendicular lean mass ( 33097823) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Cirrhosis (alcohol related) ( 32853455) Height ( 31562340 25282103) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Mild age-related type 2 diabetes ( 34737425) Nonalcoholic fatty liver disease ( 29385134) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30578418) Red cell distribution width ( 28957414) Refractive error ( 32231278) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 29483656 25056061 23974872) Serum metabolite levels ( 33031748) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Strenuous sports or other exercises ( 29899525) Type 2 diabetes ( 28869590)
Interacting Genes		7 interacting genes: DUSP14 GATAD2A GRSF1 OGT POT1 PPP2CA TRAF4	22 interacting genes: ARRDC2 BABAM1 BST2 CBFA2T3 CEBPA CREBBP H2AC20 H2BC21 H3C1 H4C1 ISYNA1 ITGB3BP KAT2B KRT32 KRT34 KRT40 MBD2 MBD3 PAK4 RASA2 SPOP TMEM161A
Entrez ID		51477	54815
HPRD ID		17163	11741
Ensembl ID		ENSG00000105655	ENSG00000167491
Uniprot IDs		A0A140VK73 Q9NPH2	Q86YP4
PDB IDs			2L2L
Enriched GO Terms of Interacting Partners?		Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Regulation Of Glycolytic Process RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Regulation Of Purine Nucleotide Metabolic Process Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Telomeric Loop Disassembly Positive Regulation Of Mitochondrial RNA Catabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Protein O-acetylglucosaminyltransferase Activity 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Phosphoprotein Phosphatase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Chromosome Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Single-stranded Telomeric DNA Binding Telomeric D-loop Binding Telomere Assembly Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Shelterin Complex Mitochondrial RNA Catabolic Process Regulation Of Primary Metabolic Process RNA Catabolic Process Carbon Catabolite Regulation Of Transcription Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Positive Regulation Of Macromolecule Metabolic Process G-quadruplex RNA Binding DEAD/H-box RNA Helicase Binding Protein Serine/threonine Phosphatase Complex Peptidyl-threonine Dephosphorylation Regulation Of Transcription By Glucose Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Thioesterase Binding G-rich Strand Telomeric DNA Binding	Chromatin Remodeling Chromatin Organization N-terminal Peptidyl-lysine Acetylation Structural Constituent Of Chromatin Nucleosome Chromosome Response To Nutrient Levels Epigenetic Regulation Of Gene Expression Response To Bisphenol A Structural Constituent Of Skin Epidermis Protein Heterodimerization Activity Peptidyl-lysine Acetylation N-terminal Protein Amino Acid Acetylation Intermediate Filament Organization Ventricular Cardiac Muscle Tissue Development Regulation Of DNA Repair Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process NuRD Complex Acetyltransferase Activity Protein-containing Complex Nucleosome Assembly Hematopoietic Stem Cell Proliferation Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Methyl-CpG Binding Nucleosome Organization Granulocyte Differentiation Positive Regulation Of DNA Repair Histone Acetyltransferase Activity Heterochromatin Formation Protein Acetylation DNA Methylation-dependent Constitutive Heterochromatin Formation Intermediate Filament Negative Regulation Of Plasmacytoid Dendritic Cell Cytokine Production Embryonic Organ Development RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Gene Expression, Epigenetic Nucleosomal DNA Binding Inositol-3-phosphate Synthase Activity Nucleoplasm DNA-binding Transcription Factor Binding Structural Molecule Activity Protein-DNA Complex Assembly Heterochromatin Negative Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Dendritic Cell Cytokine Production Regulation Of Glycolytic Process Response To Vitamin B2
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