GATAD2A and RASA2

		GATAD2A	RASA2
Description		GATA zinc finger domain containing 2A	RAS p21 protein activator 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome NuRD Complex Nuclear Speck	Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Protein-macromolecule Adaptor Activity Sequence-specific DNA Binding Metal Ion Binding	GTPase Activator Activity Protein Binding Phospholipid Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of Stem Cell Differentiation	Signal Transduction Intracellular Signal Transduction Negative Regulation Of Ras Protein Signal Transduction Regulation Of Intracellular Signal Transduction
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	Regulation of RAS by GAPs
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Cirrhosis (alcohol related) ( 32853455) Height ( 31562340 25282103) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Mild age-related type 2 diabetes ( 34737425) Nonalcoholic fatty liver disease ( 29385134) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30578418) Red cell distribution width ( 28957414) Refractive error ( 32231278) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 29483656 25056061 23974872) Serum metabolite levels ( 33031748) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Strenuous sports or other exercises ( 29899525) Type 2 diabetes ( 28869590)	Adult body size ( 32376654) Allergic disease (asthma, hay fever or eczema) ( 29083406) Basophil count ( 32888494) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807 25673413 28892062 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Eosinophil count ( 32888494) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 28552196) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Male-pattern baldness ( 28196072) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Prion diseases ( 22210626) Red blood cell count ( 32888494) Red blood cell traits ( 23222517) Refractive error ( 32231278) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist circumference adjusted for body mass index ( 34021172) Weight ( 28552196) White blood cell count ( 27863252 32888494)
Interacting Genes		22 interacting genes: ARRDC2 BABAM1 BST2 CBFA2T3 CEBPA CREBBP H2AC20 H2BC21 H3C1 H4C1 ISYNA1 ITGB3BP KAT2B KRT32 KRT34 KRT40 MBD2 MBD3 PAK4 RASA2 SPOP TMEM161A	3 interacting genes: GATAD2A GNA12 HRAS
Entrez ID		54815	5922
HPRD ID		11741	03351
Ensembl ID		ENSG00000167491	ENSG00000155903
Uniprot IDs		Q86YP4	Q15283
PDB IDs		2L2L
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization N-terminal Peptidyl-lysine Acetylation Structural Constituent Of Chromatin Nucleosome Chromosome Response To Nutrient Levels Epigenetic Regulation Of Gene Expression Response To Bisphenol A Structural Constituent Of Skin Epidermis Protein Heterodimerization Activity Peptidyl-lysine Acetylation N-terminal Protein Amino Acid Acetylation Intermediate Filament Organization Ventricular Cardiac Muscle Tissue Development Regulation Of DNA Repair Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process NuRD Complex Acetyltransferase Activity Protein-containing Complex Nucleosome Assembly Hematopoietic Stem Cell Proliferation Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Methyl-CpG Binding Nucleosome Organization Granulocyte Differentiation Positive Regulation Of DNA Repair Histone Acetyltransferase Activity Heterochromatin Formation Protein Acetylation DNA Methylation-dependent Constitutive Heterochromatin Formation Intermediate Filament Negative Regulation Of Plasmacytoid Dendritic Cell Cytokine Production Embryonic Organ Development RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Gene Expression, Epigenetic Nucleosomal DNA Binding Inositol-3-phosphate Synthase Activity Nucleoplasm DNA-binding Transcription Factor Binding Structural Molecule Activity Protein-DNA Complex Assembly Heterochromatin Negative Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Dendritic Cell Cytokine Production Regulation Of Glycolytic Process Response To Vitamin B2	G Protein Activity D5 Dopamine Receptor Binding GTPase Complex Phospholipase C Activator Activity Small GTPase-mediated Signal Transduction Rho-activating G Protein-coupled Receptor Signaling Pathway GTPase Activity GTP Binding Oncogene-induced Cell Senescence
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