UBE2J1 and SEC11C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UBE2J1	SEC11C
Description		ubiquitin conjugating enzyme E2 J1	SEC11 homolog C, signal peptidase complex subunit
Image		No pdb structure
GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Endoplasmic Reticulum Signal Peptidase Complex Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity
	Biological Process	Protein Polyubiquitination Spermatid Development Regulation Of Macrophage Cytokine Production Protein Ubiquitination Protein N-linked Glycosylation Via Asparagine Regulation Of Tumor Necrosis Factor Production ERAD Pathway Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	Signal Peptide Processing Proteolysis
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins
Drugs
Diseases
GWAS			Alzheimer's disease (age of onset) ( 22005931) Chronotype ( 30696823) Morning person ( 30696823)
Interacting Genes		50 interacting genes: AQP2 AQP6 BIRC2 BRCA1 CD79A CDS1 CLTRN CREB3 CYB561 DIO2 EBP ELOVL4 FAM209A FAM210B FCER1G GKN1 GOLT1A JAGN1 LAPTM5 LRSAM1 LY6G6C LYVE1 MAPKAPK2 MS4A6E PJA2 PLPPR2 PRKN PROKR2 REEP4 RNF2 SEC11C SLC10A6 SLC26A5 SLC33A2 SLC71A2 SYVN1 TLCD4 TM4SF18 TM4SF19 TMEM14B TMEM31 TMEM51 TMX2 TOPORS TRHR TRIM27 TRIM63 UBA1 UBC UBR5	23 interacting genes: BTN2A2 C2 CADM3 GLP1R HMOX1 MFF PLPP6 PRSS23 RTP2 SCD SELENOM SERP1 STX12 TMEM128 TMEM243 TMEM254 TMEM42 TREX1 TSNARE1 UBE2J1 VAMP1 VAMP4 VAPA
Entrez ID		51465	90701
HPRD ID		15599	15310
Ensembl ID		ENSG00000198833	ENSG00000166562
Uniprot IDs		Q9Y385	K7EJQ7 Q9BY50
PDB IDs			7P2Q
Enriched GO Terms of Interacting Partners?		Membrane Ubiquitin-protein Transferase Activity Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Polyubiquitination Endoplasmic Reticulum Membrane Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Protein Binding Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Modification-dependent Protein Catabolic Process Renal Water Transport Protein K48-linked Ubiquitination Transferase Activity Ubiquitin Ligase Complex Negative Regulation Of Response To Endoplasmic Reticulum Stress Protein K29-linked Ubiquitination Protein Modification Process	SNARE Complex Membrane SNAP Receptor Activity Organelle Fusion Vesicle Organization Membrane Fusion SNARE Complex Assembly Establishment Of Protein Localization Organelle Localization By Membrane Tethering Membrane Docking Hormone Secretion Hormone Transport Endoplasmic Reticulum Membrane Vesicle Fusion Organelle Membrane Fusion Endoplasmic Reticulum Synaptic Vesicle Signal Release Glucagon-like Peptide 1 Receptor Activity Monounsaturated Fatty Acid Biosynthetic Process Organic Hydroxy Compound Transport Immune Complex Formation Adenyl Deoxyribonucleotide Binding Immune Response In Brain Or Nervous System Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process
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