HEMK1 and SPRYD7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HEMK1	SPRYD7
Description		HemK methyltransferase 1, mitochondrial release factors N(5)-glutamine	SPRY domain containing 7
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion
	Molecular Function	Nucleic Acid Binding DNA Binding Protein Binding Methyltransferase Activity N-methyltransferase Activity Protein Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Transferase Activity Protein-glutamine N-methyltransferase Activity Peptide Chain Release Factor N(5)-glutamine Methyltransferase Activity	Protein Binding
	Biological Process	Translational Termination Methylation
Pathways
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cocaine dependence ( 31212010) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) Height ( 28552196)	Waist-to-hip ratio adjusted for body mass index ( 28430825)
Interacting Genes		18 interacting genes: AKAP8L ASCL3 CDC23 CHN1 CTAG1A CTAG1B HEATR9 INCA1 KRTAP19-1 MAGED1 PEF1 POU2AF1 PSMB4 SHOX SOHLH1 SPRYD7 TUBGCP5 UBQLN2	15 interacting genes: AGXT AQP1 CAMK2B HEMK1 NHERF4 NTAQ1 OTX1 POGZ TLX3 TRIM55 TRIM63 TRIP13 UBASH3A VAC14 YPEL3
Entrez ID		51409	57213
HPRD ID		13645	08486
Ensembl ID		ENSG00000114735	ENSG00000123178
Uniprot IDs		A0A140VK98 B2RA37 Q9Y5R4	A0A024RDT6 Q5W111
PDB IDs			7CCB
Enriched GO Terms of Interacting Partners?			L-serine-pyruvate Transaminase Activity Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Fluid Transport Nitric Oxide Transmembrane Transporter Activity Metanephric Proximal Convoluted Tubule Segment 2 Development Water Transport Diencephalon Morphogenesis Protein-glutamine N-methyltransferase Activity Peptide Chain Release Factor N(5)-glutamine Methyltransferase Activity Protein-N-terminal Glutamine Amidohydrolase Activity PAS Complex Guanylate Cyclase Inhibitor Activity
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