HEMK1 and TUBGCP5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HEMK1	TUBGCP5
Description		HemK methyltransferase 1, mitochondrial release factors N(5)-glutamine	tubulin gamma complex component 5
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion	Spindle Pole Gamma-tubulin Complex Gamma-tubulin Ring Complex Cytoplasm Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Cilium Ciliary Basal Body
	Molecular Function	Nucleic Acid Binding DNA Binding Protein Binding Methyltransferase Activity N-methyltransferase Activity Protein Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Transferase Activity Protein-glutamine N-methyltransferase Activity Peptide Chain Release Factor N(5)-glutamine Methyltransferase Activity	Protein Binding Microtubule Binding Gamma-tubulin Binding Microtubule Minus-end Binding
	Biological Process	Translational Termination Methylation	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule Nucleation Cytoplasmic Microtubule Organization Spindle Assembly Meiotic Cell Cycle
Pathways			Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cocaine dependence ( 31212010) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) Height ( 28552196)	Bipolar disorder ( 34099189) Obsessive-compulsive disorder ( 30456828) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		18 interacting genes: AKAP8L ASCL3 CDC23 CHN1 CTAG1A CTAG1B HEATR9 INCA1 KRTAP19-1 MAGED1 PEF1 POU2AF1 PSMB4 SHOX SOHLH1 SPRYD7 TUBGCP5 UBQLN2	4 interacting genes: CLIC6 CRYAA HEMK1 TMEM132D
Entrez ID		51409	114791
HPRD ID		13645	12177
Ensembl ID		ENSG00000114735	ENSG00000275835
Uniprot IDs		A0A140VK98 B2RA37 Q9Y5R4	Q96RT8
PDB IDs			6L81 6V69 6V6S 7AS4 7QJ0 7QJ1 7QJ2 7QJ3 7QJ4 7QJ5 7QJ6 7QJ7 7QJ8 7QJ9 7QJA 7QJB 7QJC 7QJD 7QJE 8Q62 8RX1 8VRD 8VRJ 8VRK
Enriched GO Terms of Interacting Partners?			Protein-glutamine N-methyltransferase Activity Peptide Chain Release Factor N(5)-glutamine Methyltransferase Activity D4 Dopamine Receptor Binding D3 Dopamine Receptor Binding D2 Dopamine Receptor Binding N-methyltransferase Activity Lens Fiber Cell Morphogenesis Tubulin Complex Assembly Response To UV-A Embryonic Camera-type Eye Morphogenesis Lens Morphogenesis In Camera-type Eye Protein Methyltransferase Activity Translational Termination
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