ATP6V1D and KRT27

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ATP6V1D	KRT27
Description		ATPase H+ transporting V1 subunit D	keratin 27
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Vacuolar Proton-transporting V-type ATPase, V1 Domain Nucleoplasm Cytoplasm Lysosomal Membrane Centrosome Cytosol Cytoskeleton Plasma Membrane Cilium Endosome Membrane Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Proton-transporting V-type ATPase Complex Specific Granule Membrane Cell Projection Extracellular Exosome Extrinsic Component Of Synaptic Vesicle Membrane	Cytoplasm Cytosol Cytoskeleton Intermediate Filament Keratin Filament Extracellular Exosome
	Molecular Function	Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Monoatomic Ion Transport Vacuolar Acidification Lysosomal Lumen Acidification Regulation Of Macroautophagy Cell Projection Organization Endosomal Lumen Acidification Intracellular PH Reduction Cilium Assembly Protein Localization To Cilium Golgi Lumen Acidification Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport	Morphogenesis Of An Epithelium Epithelial Cell Differentiation Hair Follicle Morphogenesis Intermediate Filament Organization
Pathways		ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport	Keratinization Formation of the cornified envelope
Drugs		Tiludronic acid
Diseases
GWAS			Asthma ( 31959851)
Interacting Genes		6 interacting genes: GOLGA2 HAUS1 KRT27 NDC80 TOMM34 VPS52	139 interacting genes: AARD ABI2 AMOT ARFIP1 ARHGEF6 ATP6V1D BCAS2 BEX2 BFSP2 C19orf44 C1orf216 C21orf58 CCBE1 CCDC138 CCDC146 CCDC185 CCDC187 CCDC22 CCDC68 CCHCR1 CCNC CEP95 CFAP58 COX5B DPPA3 DTNB DUSP26 EXOC3L1 EXOSC5 FAM107A FAM110A FMNL2 GADD45GIP1 GFAP GNG13 GOLGA1 GPS2 GSTK1 HAPLN2 HDAC4 HGS HOXB9 HSPBP1 ICA1L IGF1R INSR INSRR JOSD1 KANK2 KIAA1217 KLHL38 KRT1 KRT2 KRT20 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT7 KRT71 KRT72 KRT74 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT81 KRT82 KRT83 KRT85 KRT86 LKAAEAR1 LMNTD2 MATR3 MBD3L2 MID2 MORN4 MOS MTMR9 NDC80 NDUFAF3 NTAQ1 NUP54 NUP58 ODAD3 OIP5 PBX3 PCDHB14 PNN POLL PPP1R18 PRPH PSMC5 RASAL3 RBM41 RCOR3 RNF39 RTP5 RUNX1T1 SCNM1 SDHAF1 SEMA4C SLC22A5 SLIRP SMARCC2 SMARCD1 SMARCE1 SSC5D SSX3 SUFU SUOX TBRG4 TEAD4 TEDC2 TEX28 THAP7 TNNT1 TRAF3IP3 TRIML2 TSKS TTC23 TXLNB TXN2 USHBP1 USP2 VPS37C WASHC3 XRCC4 ZC3H14 ZFYVE26 ZNF3 ZNF580 ZNF581 ZNF669 ZNF80
Entrez ID		51382	342574
HPRD ID		16524	17244
Ensembl ID		ENSG00000100554	ENSG00000171446
Uniprot IDs		Q9Y5K8	Q7Z3Y8
PDB IDs		6WLZ 6WM2 6WM3 6WM4 7U4T 7UNF
Enriched GO Terms of Interacting Partners?		Spindle Assembly Meiotic Spindle Assembly Spindle Organization Meiotic Spindle Organization Membraneless Organelle Assembly Syntaxin Binding Centrosome Cycle Cytoskeleton Organization Microtubule Cytoskeleton Organization Microtubule Organizing Center Organization Cell Division Embryonic Ectodermal Digestive Tract Development Kinetochore Adaptor Activity Mitotic Spindle Organization G2/MI Transition Of Meiotic Cell Cycle Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Protein Glycosylation Spindle Pole Organelle Assembly Meiotic Cell Cycle Phase Transition Ndc80 Complex Spindle Assembly Involved In Female Meiosis I GARP Complex EARP Complex Ectodermal Cell Differentiation Skeletal Muscle Satellite Cell Proliferation Microtubule-based Process Golgi Disassembly Protein Targeting Regulation Of Protein Glycosylation Vesicle-mediated Cholesterol Transport HAUS Complex Microtubule Binding Importin-alpha Family Protein Binding Golgi Ribbon Formation Skeletal Muscle Cell Proliferation Golgi Cis Cisterna Golgi Vesicle Transport Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Spindle Assembly Involved In Female Meiosis Asymmetric Cell Division Organelle Organization Microtubule Mitotic Spindle Microtubule Positive Regulation Of Glycoprotein Metabolic Process Establishment Of Protein Localization Positive Regulation Of Glycoprotein Biosynthetic Process Golgi To Vacuole Transport Embryonic Digestive Tract Development Outer Kinetochore	Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Keratinization Keratin Filament Supramolecular Fiber Organization Cytoskeleton Organization Protein Binding Organelle Organization Insulin Receptor Activity Structural Constituent Of Cytoskeleton Insulin Receptor Complex Intermediate Filament Cytoskeleton Structural Molecule Activity Insulin Receptor Substrate Binding Epidermis Development Brahma Complex NpBAF Complex RSC-type Complex NBAF Complex Phosphatidylinositol 3-kinase Binding Nucleosome Disassembly Insulin Binding
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