UCHL5 and ARG1

Number of citations of the paper that reports this interaction (PubMedID 21800051)
0

Data Source:
BioGRID (pull down)

		UCHL5	ARG1
Description		ubiquitin C-terminal hydrolase L5	arginase 1
Image
GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Ino80 Complex	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Azurophil Granule Lumen Specific Granule Lumen
	Molecular Function	RNA Binding Cysteine-type Deubiquitinase Activity Endopeptidase Inhibitor Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Proteasome Binding	Arginase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amidines Manganese Ion Binding Metal Ion Binding
	Biological Process	Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Remodeling Proteolysis Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Deubiquitination Lateral Ventricle Development Midbrain Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Organization Positive Regulation Of DNA Repair Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Forebrain Morphogenesis Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Telomere Maintenance In Response To DNA Damage	Urea Cycle Adaptive Immune Response Immune System Process Arginine Metabolic Process L-arginine Catabolic Process Response To Nematode Regulation Of Cell Population Proliferation Negative Regulation Of T Cell Proliferation Defense Response To Protozoan Innate Immune Response Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of Type II Interferon-mediated Signaling Pathway Positive Regulation Of Neutrophil Mediated Killing Of Fungus Negative Regulation Of T-helper 2 Cell Cytokine Production
Pathways		Downregulation of TGF-beta receptor signaling UCH proteinases UCH proteinases	Neutrophil degranulation Urea cycle
Drugs			Ornithine 2(S)-Amino-6-Boronohexanoic Acid nor-NOHA Dinor-N(Omega)-Hydroxy-L-Arginine S-{2-[Amino(Dihydroxy)-Lambda~4~-Sulfanyl]Ethyl}-D-Cysteine N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine S-2-(Boronoethyl)-L-Cysteine Urea Descarboxy-nor-N(Omega)-Hydroxy-L-Arginine S,S-(2-Hydroxyethyl)Thiocysteine DEHYDRO-2(S)-AMINO-6-BORONOHEXANOIC ACID S-propylamine-L-cysteine Manganese
Diseases			Hyperargininemia
GWAS		Cannabis dependence ( 21668797)	Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) C-reactive protein levels ( 24763700) Change in glucose in response to thiazide diuretic treatment in hypertension ( 29523524) Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766 31015462 31152163 31451708) Estimated glomerular filtration rate in diabetes ( 31451708) Glomerular filtration rate ( 29403010) HDL cholesterol levels ( 32203549) Obesity ( 21552555) Serum metabolite levels ( 33031748) Type 2 diabetes ( 30054458)
Interacting Genes		104 interacting genes: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 ANXA8L1 APP ARG1 ASPRV1 AXIN1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 E2F1 E2F2 E2F3 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HAUS7 HBA1 HBA2 HBB HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA MAP3K1 NACA OGT PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL RNF4 S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TCF7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBC USP28 YWHAZ ZBED1	6 interacting genes: ALDH4A1 ARG2 CDC42 FLOT1 NOS1 UCHL5
Entrez ID		51377	383
HPRD ID		10293	01947
Ensembl ID		ENSG00000116750	ENSG00000118520
Uniprot IDs		Q5LJA5 Q9Y5K5	A0A5F9ZH78 P05089
PDB IDs		3A7S 3IHR 3RII 3RIS 3TB3 4UEL 4UEM 4UF5 4UF6 4WLP	1WVA 1WVB 2AEB 2PHA 2PHO 2PLL 2ZAV 3DJ8 3E6K 3E6V 3F80 3GMZ 3GN0 3KV2 3LP4 3LP7 3MFV 3MFW 3MJL 3SJT 3SKK 3TF3 3TH7 3THE 3THH 3THJ 4FCI 4FCK 4GSM 4GSV 4GSZ 4GWC 4GWD 4HWW 4HXQ 4IE1 6Q92 6Q9P 6QAF 6V7C 6V7D 6V7E 6V7F 7K4G 7K4H 7K4I 7K4J 7K4K 7KLK 7KLL 7KLM 7LEX 7LEY 7LEZ 7LF0 7LF1 7LF2 8AUP 8E5M 8E5N
Enriched GO Terms of Interacting Partners?		CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Extracellular Exosome Regulation Of Megakaryocyte Differentiation Protein Localization To Chromosome, Centromeric Region Protein Localization To Chromatin Nucleosome Assembly Cornified Envelope Nucleosome Organization Structural Constituent Of Chromatin Negative Regulation Of Myeloid Cell Differentiation Protein Localization To Chromosome Nucleosome Protein-DNA Complex Assembly Telomere Organization Protein-containing Complex Chromosome, Telomeric Region Negative Regulation Of Cell Differentiation Intermediate Filament Organization Chromatin Remodeling Regulation Of Myeloid Cell Differentiation Structural Constituent Of Skin Epidermis Regulation Of Hemopoiesis Chromatin Organization Extracellular Region Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Epithelial Cell Differentiation Negative Regulation Of Developmental Process Desmosome Regulation Of Cell Development Organelle Organization Peptide Cross-linking Regulation Of Cell Differentiation Protein Heterodimerization Activity Intermediate Filament Keratin Filament Keratinocyte Differentiation Supramolecular Fiber Organization Protein Localization To Organelle RNA Binding Chromosome Organization Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Regulation Of Multicellular Organismal Process Nucleus Regulation Of Immune System Process Epidermal Cell Differentiation Haptoglobin Binding	Arginine Metabolic Process Nitric Oxide Biosynthetic Process Alpha-amino Acid Metabolic Process Regulation Of Neurotransmitter Uptake Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Amino Acid Metabolic Process Adherens Junction Organization Glutamine Family Amino Acid Metabolic Process Striated Muscle Contraction Negative Regulation Of Chemokine (C-C Motif) Ligand 4 Production Caveola L-amino Acid Catabolic Process Proteinogenic Amino Acid Catabolic Process L-glutamate Gamma-semialdehyde Dehydrogenase Activity Cell Periphery Negative Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Arginase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amidines Positive Regulation Of Signal Transduction Endothelin Receptor Signaling Pathway Involved In Heart Process GBD Domain Binding Storage Vacuole Sarcolemma Nitric-oxide Synthase Activity Negative Regulation Of Serotonin Uptake Tetrahydrobiopterin Binding Amino Acid Catabolic Process Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Synaptic Signaling By Nitric Oxide Peptidyl-cysteine S-nitrosylase Activity L-proline Catabolic Process To L-glutamate Positive Regulation Of Synaptic Transmission, Dopaminergic Organic Acid Metabolic Process Carboxylic Acid Metabolic Process Negative Regulation Of Defense Response To Bacterium Positive Regulation Of Endocytosis Apolipoprotein A-I Receptor Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Neuropilin Signaling Pathway Regulation Of Serotonin Uptake L-amino Acid Metabolic Process Trans-4-hydroxy-L-proline Catabolic Process L-proline Catabolic Process Cell-cell Junction Organization Negative Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of The Force Of Heart Contraction
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