POMP and PSMB10

Number of citations of the paper that reports this interaction (PubMedID 17948026)
19

Data Source:
BioGRID (two hybrid)

		POMP	PSMB10
Description		proteasome maturation protein	proteasome 20S subunit beta 10
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GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Membrane Nuclear Speck	Proteasome Complex Nucleus Cytoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Spermatoproteasome Complex
	Molecular Function	Protein Binding	Endopeptidase Activity Threonine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity
	Biological Process	Proteasome Assembly	Cell Morphogenesis Proteolysis Humoral Immune Response T Cell Proliferation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process
Pathways		Proteasome assembly Proteasome assembly	ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation
Drugs			Carfilzomib
Diseases		Keratosis linearis with ichthyosis congenita and sclerosing keratoderma; KLICK syndrome
GWAS		Breast cancer (menopausal hormone therapy interaction) ( 24080446) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Red blood cell count ( 32888494) Refractive error ( 32231278)	Crohn's disease ( 22412388) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		24 interacting genes: ATXN1 CAPN3 DCPH1 ECT2 FAM107A GPD1 GRB2 KCNA10 KIF1B KLHL41 MPPED2 PSMA3 PSMB1 PSMB10 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PYGM RBM5 SSR4 TTN VCL	12 interacting genes: ANXA7 CCNDBP1 CRX MEOX2 POMP PSKH1 PSMA1 PSMA2 PSMA3 PSMB8 PSMB9 PTN
Entrez ID		51371	5699
HPRD ID		12613	01465
Ensembl ID		ENSG00000132963	ENSG00000205220
Uniprot IDs		Q9Y244	P40306
PDB IDs		8QYJ 8QYL 8QYM 8QYN 8QYS 8QZ9 8TM4 8TM5 8TM6 8YIX 8YIY	6AVO 6E5B 6HV3 6HV4 6HV5 6HV7 6HVA 6HVR 6HVS 6HVT 6HVU 6HVV 6HVW 7AWE 7B12 9FSV
Enriched GO Terms of Interacting Partners?		Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Threonine-type Endopeptidase Activity Proteasome Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Endopeptidase Activity Protein Catabolic Process Proteasomal Protein Catabolic Process Spermatoproteasome Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Peptidase Activity Proteolysis Catabolic Process Extracellular Exosome Myofibril Assembly Cytosol Cytoplasm Hydrolase Activity Actomyosin Structure Organization M Band Secretory Granule Lumen Ficolin-1-rich Granule Lumen Response To Calcium Ion Insulin-like Growth Factor Receptor Signaling Pathway Calcium-dependent Self Proteolysis Protein-containing Complex Assembly Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Glycerol-3-phosphate Dehydrogenase (NAD+) Activity Guanyl-nucleotide Exchange Factor Adaptor Activity Inner Dense Plaque Of Desmosome Podosome Ring Outer Dense Plaque Of Desmosome Protein Carboxyl O-methyltransferase Activity Protein-glutamate O-methyltransferase Activity Fructose 6-phosphate Aldolase Activity Actin Cytoskeleton Organization Sarcomere Organization Structural Constituent Of Muscle Myofibril Actin Filament-based Process Ligase Regulator Activity Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Protein-containing Complex Organization Cell-cell Junction Glycerol-3-phosphate Dehydrogenase [NAD(P)+] Activity Glycerol-3-phosphate Catabolic Process Glycerol-3-phosphate Shuttle	Proteasome Core Complex Proteasome Complex Proteasome Core Complex, Alpha-subunit Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Spermatoproteasome Complex Proteasomal Protein Catabolic Process Threonine-type Endopeptidase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteasome Core Complex, Beta-subunit Complex Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Nucleus Macromolecule Catabolic Process Proteolysis Catabolic Process Extracellular Exosome Dendrite Regeneration Endopeptidase Activity Ossification Involved In Bone Remodeling Nuclear Speck
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