POMP and KIF1B

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		POMP	KIF1B
Description		proteasome maturation protein	kinesin family member 1B
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GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Membrane Nuclear Speck	Cytoplasm Mitochondrion Cytoskeleton Kinesin Complex Microtubule Membrane Axon Dendrite Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuron Projection Synapse Presynapse Postsynapse Axon Cytoplasm
	Molecular Function	Protein Binding	Nucleotide Binding Cytoskeletal Motor Activity Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity Isomerase Activity ATP Hydrolysis Activity Kinesin Binding
	Biological Process	Proteasome Assembly	Apoptotic Process Microtubule-based Movement Neuron-neuron Synaptic Transmission Neuromuscular Synaptic Transmission Transport Along Microtubule Vesicle-mediated Transport Mitochondrion Transport Along Microtubule Anterograde Synaptic Vesicle Transport Apoptotic Process Involved In Development Retrograde Neuronal Dense Core Vesicle Transport
Pathways		Proteasome assembly Proteasome assembly	COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs
Diseases		Keratosis linearis with ichthyosis congenita and sclerosing keratoderma; KLICK syndrome	Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Breast cancer (menopausal hormone therapy interaction) ( 24080446) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Red blood cell count ( 32888494) Refractive error ( 32231278)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Hand grip strength ( 29691431) Hematocrit ( 27863252) Hepatitis B virus-related hepatocellular carcinoma ( 29246937) Hepatocellular carcinoma ( 20676096) Hip circumference adjusted for BMI ( 34021172) Lateral orbital frontal cortex volume ( 31530798) Mean platelet volume ( 27863252 22139419 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 18997785) Neutrophil count ( 32888494) Platelet count ( 32888494) Virologic severity in Herpes simplex virus type 2 infection ( 29535370) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)
Interacting Genes		24 interacting genes: ATXN1 CAPN3 DCPH1 ECT2 FAM107A GPD1 GRB2 KCNA10 KIF1B KLHL41 MPPED2 PSMA3 PSMB1 PSMB10 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PYGM RBM5 SSR4 TTN VCL	26 interacting genes: ARHGAP1 BRCA1 CALM1 CHP1 CLIP4 CPEB1 DLG1 DLG2 DLG3 DLG4 DSCR4 DYSF EEF1A1 GIPC1 KAZN LAMTOR5 PATJ PGM1 PKNOX1 POMP RSPH1 SIAH1 SNTA1 STARD13 TRIM55 YWHAG
Entrez ID		51371	23095
HPRD ID		12613	05818
Ensembl ID		ENSG00000132963	ENSG00000054523
Uniprot IDs		Q9Y244	O60333
PDB IDs		8QYJ 8QYL 8QYM 8QYN 8QYS 8QZ9 8TM4 8TM5 8TM6 8YIX 8YIY	2EH0
Enriched GO Terms of Interacting Partners?		Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Threonine-type Endopeptidase Activity Proteasome Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Endopeptidase Activity Protein Catabolic Process Proteasomal Protein Catabolic Process Spermatoproteasome Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Peptidase Activity Proteolysis Catabolic Process Extracellular Exosome Myofibril Assembly Cytosol Cytoplasm Hydrolase Activity Actomyosin Structure Organization M Band Secretory Granule Lumen Ficolin-1-rich Granule Lumen Response To Calcium Ion Insulin-like Growth Factor Receptor Signaling Pathway Calcium-dependent Self Proteolysis Protein-containing Complex Assembly Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Glycerol-3-phosphate Dehydrogenase (NAD+) Activity Guanyl-nucleotide Exchange Factor Adaptor Activity Inner Dense Plaque Of Desmosome Podosome Ring Outer Dense Plaque Of Desmosome Protein Carboxyl O-methyltransferase Activity Protein-glutamate O-methyltransferase Activity Fructose 6-phosphate Aldolase Activity Actin Cytoskeleton Organization Sarcomere Organization Structural Constituent Of Muscle Myofibril Actin Filament-based Process Ligase Regulator Activity Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Protein-containing Complex Organization Cell-cell Junction Glycerol-3-phosphate Dehydrogenase [NAD(P)+] Activity Glycerol-3-phosphate Catabolic Process Glycerol-3-phosphate Shuttle	Establishment Or Maintenance Of Apical/basal Cell Polarity Kinase Binding Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Neuromuscular Junction Ionotropic Glutamate Receptor Binding Receptor Localization To Synapse Receptor Clustering Protein Localization To Synapse Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Establishment Or Maintenance Of Cell Polarity Cytoplasm Protein Localization To Cell Junction Postsynaptic Density Membrane Regulation Of Sodium Ion Transmembrane Transport Protein Kinase Binding Cytosol GMP Kinase Activity Chemical Synaptic Transmission Neuron Projection Trans-synaptic Signaling Regulation Of Sodium Ion Transport Cytoplasmic Microtubule Organization Synaptic Signaling GDP Metabolic Process Juxtaparanode Region Of Axon Adherens Junction Cellular Response To Potassium Ion Voltage-gated Potassium Channel Complex Ribonucleoside Diphosphate Metabolic Process Regulation Of Synaptic Plasticity Nucleoside Diphosphate Metabolic Process Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Intracellular Signal Transduction Negative Regulation Of Transport Response To Potassium Ion Postsynaptic Density Regulation Of Cell Communication Regulation Of Signaling Regulation Of Monoatomic Cation Transmembrane Transport Sarcolemma Protein K6-linked Ubiquitination Regulation Of Signal Transduction Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Biological Quality Modulation Of Chemical Synaptic Transmission GMP Metabolic Process AMPA Glutamate Receptor Complex Intracellular Signal Transduction Bicellular Tight Junction Regulation Of Monoatomic Ion Transmembrane Transport
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