TAOK3 and ATF7

Number of citations of the paper that reports this interaction (PubMedID 20195357)
57

Data Source:
BioGRID (pull down)

		TAOK3	ATF7
Description		TAO kinase 3	activating transcription factor 7
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lipid Droplet Plasma Membrane Membrane Membrane Raft	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Enzyme Binding CAMP Response Element Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	MAPK Cascade DNA Repair Protein Phosphorylation DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Positive Regulation Of Stress-activated MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Neuron Projection Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs		Fostamatinib	Pseudoephedrine
Diseases
GWAS		Depression ( 33859377) Glucose homeostasis traits ( 25524916) Hip circumference ( 28552196) Loneliness ( 31518406) Morphine dose requirement in tonsillectomy and adenoidectomy surgery ( 24909733) Post bronchodilator FEV1 in COPD ( 26634245) Red cell distribution width ( 27863252 32888494) Systemic lupus erythematosus ( 19838195)	Basophil count ( 32888494) Electroencephalogram traits ( 25387704) Heel bone mineral density ( 30598549) Height ( 20189936 21998595 25429064 31562340) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: ATF7 CEBPA ERN1 LRRK2 SMURF1 TRAF2	18 interacting genes: ATF2 FAM9B FCER2 FOS KASH5 MAPK9 MBD3 MITD1 OCIAD1 PTP4A1 PTP4A2 TAF12 TAF4 TAOK3 TMEM239 UBC URI1 YY1
Entrez ID		51347	11016
HPRD ID		11620	06968
Ensembl ID		ENSG00000135090	ENSG00000170653
Uniprot IDs		G3V1Q8 Q9H2K8	P17544
PDB IDs		6BDN
Enriched GO Terms of Interacting Partners?		IRE1-TRAF2-ASK1 Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macrophage Activation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Macrophage Activation Positive Regulation Of Biosynthetic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Proteolysis Response To Vitamin B2 Positive Regulation Of Macromolecule Biosynthetic Process C/EBP Complex Positive Regulation Of Proteasomal Protein Catabolic Process Enzyme Binding MRNA Splicing, Via Endonucleolytic Cleavage And Ligation Regulation Of Response To Endoplasmic Reticulum Stress AIP1-IRE1 Complex Positive Regulation Of MAPK Cascade Cellular Response To Reactive Oxygen Species IRE1-RACK1-PP2A Complex Ire1 Complex TORC2 Complex Disassembly TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Engulfment Of Target By Autophagosome Cellular Response To Curcumin Caveola Neck Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion GTP-dependent Protein Kinase Activity Beta-catenin Destruction Complex Binding Wnt Signalosome Assembly Regulation Of Protein Metabolic Process RNA Polymerase II Transcription Regulator Complex Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex	MRNA Transcription By RNA Polymerase II MRNA Transcription DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Abducens Nucleus Development Mitotic DNA Integrity Checkpoint Signaling Cellular Response To Anisomycin Growth Plate Cartilage Chondrocyte Differentiation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Chromatin Binding Nucleoplasm Positive Regulation Of Cardiac Muscle Myoblast Proliferation Facial Nucleus Development Histone H2B Acetyltransferase Activity Promoter-specific Chromatin Binding DNA Damage Response Hypoglossal Nucleus Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process JNK Cascade Nucleus RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cellular Response To Stress H4 Histone Acetyltransferase Complex Positive Regulation Of Transforming Growth Factor Beta2 Production Transcription By RNA Polymerase II Cellular Response To Chemical Stress Growth Plate Cartilage Chondrocyte Proliferation Positive Regulation Of RNA Metabolic Process Mitotic DNA Damage Checkpoint Signaling Cellular Response To Oxidative Stress Positive Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process MAPK Cascade B Cell Antigen Processing And Presentation Fc Receptor Signaling Pathway Low-affinity IgE Receptor Activity Fc Receptor-mediated Immune Complex Endocytosis Fc-epsilon Receptor Signaling Pathway Response To Prolactin Conditioned Taste Aversion Regulation Of MiRNA Transcription Medium-term Memory Cellular Response To Prolactin JUN Kinase Activity Protein Localization To Tricellular Tight Junction Regulation Of Cellular Response To Stress Transcription Factor TFTC Complex Transcription Factor TFIID Complex Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription Initiation
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