TAOK3

Description		TAO kinase 3
Image
GO Annotations	Cellular Component	Cytoplasm Lipid Droplet Plasma Membrane Membrane Membrane Raft
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	MAPK Cascade DNA Repair Protein Phosphorylation DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Positive Regulation Of Stress-activated MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Neuron Projection Morphogenesis
Pathways		RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs		Fostamatinib
Diseases
GWAS		Depression ( 33859377) Glucose homeostasis traits ( 25524916) Hip circumference ( 28552196) Loneliness ( 31518406) Morphine dose requirement in tonsillectomy and adenoidectomy surgery ( 24909733) Post bronchodilator FEV1 in COPD ( 26634245) Red cell distribution width ( 27863252 32888494) Systemic lupus erythematosus ( 19838195)
Novel Interacting Genes		6 novel interacting genes: ATF7 CEBPA ERN1 LRRK2 SMURF1 TRAF2
Interacting Genes		6 interacting genes: ATF7 CEBPA ERN1 LRRK2 SMURF1 TRAF2
Entrez ID		51347
HPRD ID		11620
Ensembl ID		ENSG00000135090
Uniprot IDs		G3V1Q8 Q9H2K8
PDB IDs		6BDN
Enriched GO Terms of Interacting Partners?		IRE1-TRAF2-ASK1 Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macrophage Activation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Macrophage Activation Positive Regulation Of Biosynthetic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Proteolysis Response To Vitamin B2 Positive Regulation Of Macromolecule Biosynthetic Process C/EBP Complex Positive Regulation Of Proteasomal Protein Catabolic Process Enzyme Binding MRNA Splicing, Via Endonucleolytic Cleavage And Ligation Regulation Of Response To Endoplasmic Reticulum Stress AIP1-IRE1 Complex Positive Regulation Of MAPK Cascade Cellular Response To Reactive Oxygen Species IRE1-RACK1-PP2A Complex Ire1 Complex TORC2 Complex Disassembly TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Engulfment Of Target By Autophagosome Cellular Response To Curcumin Caveola Neck Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion GTP-dependent Protein Kinase Activity Beta-catenin Destruction Complex Binding Wnt Signalosome Assembly Regulation Of Protein Metabolic Process RNA Polymerase II Transcription Regulator Complex Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex
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