ZBTB7A and SP4

Number of citations of the paper that reports this interaction (PubMedID 12004059)
0

Data Source:
HPRD (in vitro)

		ZBTB7A	SP4
Description		zinc finger and BTB domain containing 7A	Sp4 transcription factor
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Site Of Double-strand Break DNA-dependent Protein Kinase Complex	Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Histone Acetyltransferase Binding Sequence-specific DNA Binding SMAD Binding Metal Ion Binding Nuclear Androgen Receptor Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Glycolytic Process Chromatin Organization Chromatin Remodeling DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation B Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Localization To Nucleus Regulation Of Apoptotic Process Erythrocyte Maturation Fat Cell Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Androgen Receptor Signaling Pathway Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of Transcription Regulatory Region DNA Binding	Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Chronic lymphocytic leukemia ( 28165464) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Pulse pressure ( 30578418) Reaction time ( 29844566) Red blood cell count ( 27863252 32888494)	Acute lymphoblastic leukemia (childhood) ( 29348612) Age at first sexual intercourse ( 34211149) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Bipolar disorder ( 31043756 34002096) General cognitive ability ( 29844566) LDL cholesterol levels ( 32203549) Major depressive disorder ( 20125088) Major depressive disorder (broad) ( 20038947) Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma) ( 23103227) Multisite chronic pain ( 31194737 33830993) Plateletcrit ( 32888494) Schizophrenia ( 30285260) Temporomandibular joint disorder ( 28081371)
Interacting Genes		25 interacting genes: BCL6 CRBN HOMEZ HSP90AA1 KHDRBS1 MBD3 NCOR1 NCOR2 OTUD4 PRKDC PSMD14 RELA SMAD4 SP1 SP3 SP4 TRIM25 UBE2I USP10 USP17L2 XRCC5 XRCC6 YBX1 ZBTB48 ZMYND8	36 interacting genes: ADAM15 AP1M1 ATXN7L1 BANP CIB3 COL8A1 E2F1 ELK3 FOXP2 GTF2A1 HIVEP1 HYPK ITGB8 LMO3 LNX1 MCRS1 NFYC NKX3-1 NRF1 PELI2 PNKP POGZ POU2F1 PRR20A PRR20B PRR20C PRR20D PRR20E PRSS59P SERF2 SP1 SPANXN2 SPANXN3 USP7 VEZF1 ZBTB7A
Entrez ID		51341	6671
HPRD ID		10433	02764
Ensembl ID		ENSG00000178951	ENSG00000105866
Uniprot IDs		O95365	A0A3B3IRW4 Q02446 Q32M51
PDB IDs		2IF5 2NN2 7EYI 7N5S 7N5T 7N5U 7N5V 7N5W 8E3D 8E3E 8H9H
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Primary Metabolic Process Nucleoplasm Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Double-stranded DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Protein-DNA Complex Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Negative Regulation Of RNA Metabolic Process DNA-dependent Protein Kinase Complex DNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Transcription Cis-regulatory Region Binding DNA-dependent Protein Kinase-DNA Ligase 4 Complex Chromatin Regulation Of Innate Immune Response Nonhomologous End Joining Complex Positive Regulation Of Innate Immune Response Double-stranded Telomeric DNA Binding Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Telomere Maintenance Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Immune Response Activation Of Innate Immune Response Negative Regulation Of Biosynthetic Process Cellular Response To Stress Negative Regulation Of Metabolic Process DNA Recombination Telomere Organization Histone Deacetylase Binding Regulation Of Defense Response Double-strand Break Repair Via Nonhomologous End Joining Recombinational Repair Activation Of Immune Response Transcription Repressor Complex Positive Regulation Of Defense Response	Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding DNA Binding Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Binding Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Damage Response Sequence-specific Double-stranded DNA Binding
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