ZBTB7A and OTUD4

Number of citations of the paper that reports this interaction (PubMedID 37717099)
0

Data Source:
BioGRID (unspecified method)

		ZBTB7A	OTUD4
Description		zinc finger and BTB domain containing 7A	OTU deubiquitinase 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Site Of Double-strand Break DNA-dependent Protein Kinase Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Histone Acetyltransferase Binding Sequence-specific DNA Binding SMAD Binding Metal Ion Binding Nuclear Androgen Receptor Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Binding Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Molecular Adaptor Activity K63-linked Deubiquitinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Glycolytic Process Chromatin Organization Chromatin Remodeling DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation B Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Localization To Nucleus Regulation Of Apoptotic Process Erythrocyte Maturation Fat Cell Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Androgen Receptor Signaling Pathway Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of Transcription Regulatory Region DNA Binding	Immune System Process DNA Alkylation Repair Proteolysis Negative Regulation Of Toll-like Receptor Signaling Pathway Protein K11-linked Deubiquitination Protein K27-linked Ubiquitination Innate Immune Response Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Antiviral Innate Immune Response Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Chronic lymphocytic leukemia ( 28165464) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Pulse pressure ( 30578418) Reaction time ( 29844566) Red blood cell count ( 27863252 32888494)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Heel bone mineral density ( 28869591 30598549) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172 25673412) Lung function (FEV1) ( 30061609) Malaria ( 31844061) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 31628463) Red blood cell count ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		25 interacting genes: BCL6 CRBN HOMEZ HSP90AA1 KHDRBS1 MBD3 NCOR1 NCOR2 OTUD4 PRKDC PSMD14 RELA SMAD4 SP1 SP3 SP4 TRIM25 UBE2I USP10 USP17L2 XRCC5 XRCC6 YBX1 ZBTB48 ZMYND8	15 interacting genes: ALKBH3 DNAAF5 EXOSC8 MAVS PFKFB3 REL RPS6KA2 STAT1 TCF4 TEC UBC USP7 VDR ZBTB7A ZNF655
Entrez ID		51341	54726
HPRD ID		10433	11033
Ensembl ID		ENSG00000178951	ENSG00000164164
Uniprot IDs		O95365	Q01804
PDB IDs		2IF5 2NN2 7EYI 7N5S 7N5T 7N5U 7N5V 7N5W 8E3D 8E3E 8H9H
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Primary Metabolic Process Nucleoplasm Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Double-stranded DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Protein-DNA Complex Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Negative Regulation Of RNA Metabolic Process DNA-dependent Protein Kinase Complex DNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Transcription Cis-regulatory Region Binding DNA-dependent Protein Kinase-DNA Ligase 4 Complex Chromatin Regulation Of Innate Immune Response Nonhomologous End Joining Complex Positive Regulation Of Innate Immune Response Double-stranded Telomeric DNA Binding Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Telomere Maintenance Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Immune Response Activation Of Innate Immune Response Negative Regulation Of Biosynthetic Process Cellular Response To Stress Negative Regulation Of Metabolic Process DNA Recombination Telomere Organization Histone Deacetylase Binding Regulation Of Defense Response Double-strand Break Repair Via Nonhomologous End Joining Recombinational Repair Activation Of Immune Response Transcription Repressor Complex Positive Regulation Of Defense Response	Regulation Of Macromolecule Biosynthetic Process Regulation Of Type I Interferon Production Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Interferon-alpha Production Histone Acetyltransferase Binding DNA Alkylation Repair Cytosol Negative Regulation Of Macromolecule Biosynthetic Process Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Interferon-beta Production Brain Renin-angiotensin System TORC1 Signaling Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Type I Interferon-mediated Signaling Pathway Regulation Of Defense Response To Virus Negative Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Interferon-mediated Signaling Pathway Regulation Of Defense Response To Virus By Host Transcription Corepressor Binding Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Negative Regulation Of Phosphate Transmembrane Transport Calcitriol Binding MRNA Transcription Nuclear Receptor-mediated Bile Acid Signaling Pathway Bile Acid Nuclear Receptor Activity Lithocholic Acid Binding Regulation Of Peroxisome Organization Positive Regulation Of IP-10 Production MRNA N1-methyladenosine Dioxygenase Activity Nucleobase-containing Compound Metabolic Process Nucleoplasm 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase Complex 6-phosphofructo-2-kinase Activity Regulation Of DNA-templated Transcription Cytoplasm Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II NF-kappaB Complex Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Metabolic Process
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