PDCD1 and USP5

Number of citations of the paper that reports this interaction (PubMedID 37208329)
46

Data Source:
BioGRID (enzymatic study, pull down, unspecified method)

		PDCD1	USP5
Description		programmed cell death 1	ubiquitin specific peptidase 5
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Nucleus Cytoplasm Lysosome Cytosol Cytoplasmic Stress Granule Presynapse
	Molecular Function	Protein Binding Signaling Receptor Activity	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Ubiquitin Binding Metal Ion Binding Deubiquitinase Activity
	Biological Process	B Cell Apoptotic Process Adaptive Immune Response Immune System Process Negative Regulation Of Tolerance Induction Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Negative Regulation Of B Cell Apoptotic Process Apoptotic Process Humoral Immune Response Regulation Of Immune Response Negative Regulation Of Immune Response Negative Regulation Of T Cell Activation Negative Regulation Of Multicellular Organismal Process Positive Regulation Of T Cell Apoptotic Process Regulatory T Cell Apoptotic Process	Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Proteolysis Regulation Of Mitotic Cell Cycle Protein Ubiquitination Protein Deubiquitination Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of T Cell Activation Protein K48-linked Deubiquitination Regulation Protein Catabolic Process At Presynapse Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Co-inhibition by PD-1 Potential therapeutics for SARS PD-L1(CD274) glycosylation and translocation to plasma membrane	Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Drugs		CT-011 Nivolumab Pembrolizumab Atezolizumab Durvalumab Avelumab Cemiplimab Camrelizumab Spartalizumab Tislelizumab Toripalimab Dostarlimab Sintilimab Retifanlimab AMP-224 MEDI0680 Geptanolimab Budigalimab Prolgolimab
Diseases		Systemic lupus erythematosus
GWAS		Crohn's disease ( 26192919) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494)	Refractive error ( 32231278)
Interacting Genes		11 interacting genes: CD274 COPS8 MAPK3 MCL1 MDM2 OR6B3 PDCD1LG2 RNF128 RNF130 RNF167 USP5	30 interacting genes: APP CD274 DAZAP2 DVL2 ISG15 METTL3 PDCD1 PJA1 PLA2G2A RFFL RNF11 RNF216 SGTA SPART STK33 SUMO2 TADA3 TMEM239 TRIM26 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIM8 TRIML1 UBE2S UBTD2 USP28 WWP2
Entrez ID		5133	8078
HPRD ID		02590	03265
Ensembl ID		ENSG00000188389	ENSG00000111667
Uniprot IDs		A0A0M3M0G7 Q15116	A0A140VJZ1 P45974
PDB IDs		2M2D 3RRQ 4ZQK 5B8C 5GGR 5GGS 5IUS 5JXE 5WT9 6HIG 6J14 6J15 6JBT 6JJP 6K0Y 6R5G 6ROY 6ROZ 6UMT 6UMU 6UMV 6XKR 7BXA 7CGW 7CU5 7E9B 7VUX 7WSL 7WVM 8AS0 8EQ6 8GY5 8U31 8U32 9HK1	2DAG 2DAK 2G43 2G45 3IHP 6DXH 6DXT 6NFT 6P9G 7MS5 7MS6 7MS7
Enriched GO Terms of Interacting Partners?		Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Negative Regulation Of Immune Response To Tumor Cell Regulation Of T Cell Mediated Immune Response To Tumor Cell Regulation Of Response To Tumor Cell Protein Modification By Small Protein Conjugation Negative Regulation Of T Cell Activation Negative Regulation Of T Cell Mediated Immunity Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Lymphocyte Activation Post-translational Protein Modification Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Activation Negative Regulation Of Adaptive Immune Response Protein Modification Process Endomembrane System Protein Ubiquitination Negative Regulation Of Cell Adhesion Negative Regulation Of Activated T Cell Proliferation Regulation Of T Cell Mediated Immunity Ubiquitin Protein Ligase Activity Regulation Of Protein Stability Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Proteolysis Negative Regulation Of Interleukin-10 Production Positive Regulation Of Leukocyte Proliferation Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Lymphocyte Mediated Immunity Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Immune System Process Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Immune Response Regulation Of Adaptive Immune Response Regulation Of Activated T Cell Proliferation Negative Regulation Of Type II Interferon Production Modification-dependent Protein Catabolic Process T Cell Costimulation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Metabolic Process Cellular Response To Nutrient Levels	Ubiquitin Protein Ligase Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Modification Process Innate Immune Response Protein Metabolic Process Protein Polyubiquitination Defense Response To Symbiont Immune Response Defense Response To Other Organism Response To External Biotic Stimulus Response To Other Organism Protein K63-linked Ubiquitination Transferase Activity Defense Response Suppression Of Viral Release By Host Immune System Process Collateral Sprouting In Absence Of Injury Host-mediated Suppression Of Symbiont Invasion Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Catabolic Process Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Zinc Ion Binding Protein Catabolic Process Response To Stress Proteolysis Transcription Coactivator Activity Positive Regulation Of RNA Metabolic Process Proteasomal Protein Catabolic Process Canonical NF-kappaB Signal Transduction Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Ubiquitin Protein Ligase Binding Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Nucleus Positive Regulation Of T Cell Apoptotic Process Negative Regulation Of Immune Response To Tumor Cell Protein Tag Activity Cytoplasm Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of T Cell Mediated Immune Response To Tumor Cell Ubiquitin-dependent Protein Catabolic Process Collateral Sprouting Nuclear Body Positive Regulation Of Lymphocyte Apoptotic Process
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