USP5 and METTL3

Number of citations of the paper that reports this interaction (PubMedID 33217317)
72

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)

		USP5	METTL3
Description		ubiquitin specific peptidase 5	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
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GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Cytosol Cytoplasmic Stress Granule Presynapse	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Body Nuclear Speck RNA N6-methyladenosine Methyltransferase Complex Oxidoreductase Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Ubiquitin Binding Metal Ion Binding Deubiquitinase Activity	MRNA M(6)A Methyltransferase Activity RNA Binding MRNA Binding Protein Binding Methyltransferase Activity RNA Methyltransferase Activity Transferase Activity Protein Heterodimerization Activity S-adenosyl-L-methionine Binding
	Biological Process	Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Proteolysis Regulation Of Mitotic Cell Cycle Protein Ubiquitination Protein Deubiquitination Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of T Cell Activation Protein K48-linked Deubiquitination Regulation Protein Catabolic Process At Presynapse Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	MRNA Splicing, Via Spliceosome RNA Methylation Immune System Process MRNA Processing MRNA Export From Nucleus DNA Damage Response Spermatogenesis Circadian Rhythm Dosage Compensation By Inactivation Of X Chromosome MRNA Modification Stem Cell Population Maintenance Forebrain Radial Glial Cell Differentiation Cell Differentiation Primary MiRNA Processing Methylation Cellular Response To UV Gliogenesis Innate Immune Response Regulation Of T Cell Differentiation Positive Regulation Of Translation Negative Regulation Of Notch Signaling Pathway Oogenesis Rhythmic Process Regulation Of Meiotic Cell Cycle Negative Regulation Of Type I Interferon-mediated Signaling Pathway MRNA Destabilization Endothelial To Hematopoietic Transition Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Cap-independent Translational Initiation
Pathways		Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes	Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Response to Homoharringtonine (cytotoxicity) ( 25628645)
Interacting Genes		30 interacting genes: APP CD274 DAZAP2 DVL2 ISG15 METTL3 PDCD1 PJA1 PLA2G2A RFFL RNF11 RNF216 SGTA SPART STK33 SUMO2 TADA3 TMEM239 TRIM26 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIM8 TRIML1 UBE2S UBTD2 USP28 WWP2	9 interacting genes: EIF3G EIF3I EIF3J EIF3M MAPK1 MAPK14 MAPK8 MTDH USP5
Entrez ID		8078	56339
HPRD ID		03265	14389
Ensembl ID		ENSG00000111667	ENSG00000165819
Uniprot IDs		A0A140VJZ1 P45974	Q86U44
PDB IDs		2DAG 2DAK 2G43 2G45 3IHP 6DXH 6DXT 6NFT 6P9G 7MS5 7MS6 7MS7	5IL0 5IL1 5IL2 5K7M 5K7U 5K7W 5L6D 5L6E 5TEY 5YZ9 6TTP 6TTT 6TTV 6TTW 6TTX 6TU1 6Y4G 7ACD 7NHG 7NHH 7NHI 7NHJ 7NHV 7NI7 7NI8 7NI9 7NIA 7NID 7O08 7O09 7O0L 7O0M 7O0P 7O0Q 7O0R 7O27 7O28 7O29 7O2E 7O2F 7O2H 7O2I 7O2X 7OED 7OEE 7OEF 7OEG 7OEH 7OEI 7OEJ 7OEK 7OEL 7OEM 7OQL 7OQO 7OQP 7RX6 7RX7 7RX8 8BN8 8PW8 8PW9 8PWA 8PWB 9G4S 9G4U 9G4W
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Modification Process Innate Immune Response Protein Metabolic Process Protein Polyubiquitination Defense Response To Symbiont Immune Response Defense Response To Other Organism Response To External Biotic Stimulus Response To Other Organism Protein K63-linked Ubiquitination Transferase Activity Defense Response Suppression Of Viral Release By Host Immune System Process Collateral Sprouting In Absence Of Injury Host-mediated Suppression Of Symbiont Invasion Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Catabolic Process Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Zinc Ion Binding Protein Catabolic Process Response To Stress Proteolysis Transcription Coactivator Activity Positive Regulation Of RNA Metabolic Process Proteasomal Protein Catabolic Process Canonical NF-kappaB Signal Transduction Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Ubiquitin Protein Ligase Binding Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Nucleus Positive Regulation Of T Cell Apoptotic Process Negative Regulation Of Immune Response To Tumor Cell Protein Tag Activity Cytoplasm Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of T Cell Mediated Immune Response To Tumor Cell Ubiquitin-dependent Protein Catabolic Process Collateral Sprouting Nuclear Body Positive Regulation Of Lymphocyte Apoptotic Process	Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Cytoplasmic Translational Initiation Translation Initiation Factor Activity MAP Kinase Activity Translational Initiation Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Lipopolysaccharide-mediated Signaling Pathway Protein-RNA Complex Assembly Protein Metabolic Process Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Protein-containing Complex Assembly Protein-containing Complex Organization Translation Positive Regulation Of Cyclase Activity Peptidyl-threonine Phosphorylation Canonical Inflammasome Complex Assembly MAPK Cascade Macromolecule Metabolic Process Cytoplasm Macromolecule Biosynthetic Process Cellular Component Assembly Response To Lipopolysaccharide Cellular Senescence Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation JUN Phosphorylation Response To Molecule Of Bacterial Origin Cytosol Energy Homeostasis Protein Serine Kinase Activity Regulation Of Immune Response Protein Serine/threonine Kinase Activity Protein Phosphatase Binding Cytosine Metabolic Process Cellular Response To Tumor Necrosis Factor Regulation Of Synaptic Membrane Adhesion Interleukin-34-mediated Signaling Pathway JUN Kinase Activity Regulation Protein Catabolic Process At Presynapse Regulation Of Ossification Response To Nutrient Levels Ficolin-1-rich Granule Lumen Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Tumor Necrosis Factor Protein Kinase Activity Regulation Of Golgi Inheritance
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