PDCD1 and OR6B3

		PDCD1	OR6B3
Description		programmed cell death 1	olfactory receptor family 6 subfamily B member 3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding Signaling Receptor Activity	G Protein-coupled Receptor Activity Olfactory Receptor Activity Odorant Binding
	Biological Process	B Cell Apoptotic Process Adaptive Immune Response Immune System Process Negative Regulation Of Tolerance Induction Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Negative Regulation Of B Cell Apoptotic Process Apoptotic Process Humoral Immune Response Regulation Of Immune Response Negative Regulation Of Immune Response Negative Regulation Of T Cell Activation Negative Regulation Of Multicellular Organismal Process Positive Regulation Of T Cell Apoptotic Process Regulatory T Cell Apoptotic Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Smell Detection Of Chemical Stimulus Involved In Sensory Perception Of Smell
Pathways		Co-inhibition by PD-1 Potential therapeutics for SARS PD-L1(CD274) glycosylation and translocation to plasma membrane	Expression and translocation of olfactory receptors
Drugs		CT-011 Nivolumab Pembrolizumab Atezolizumab Durvalumab Avelumab Cemiplimab Camrelizumab Spartalizumab Tislelizumab Toripalimab Dostarlimab Sintilimab Retifanlimab AMP-224 MEDI0680 Geptanolimab Budigalimab Prolgolimab
Diseases		Systemic lupus erythematosus
GWAS		Crohn's disease ( 26192919) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494)
Interacting Genes		11 interacting genes: CD274 COPS8 MAPK3 MCL1 MDM2 OR6B3 PDCD1LG2 RNF128 RNF130 RNF167 USP5	3 interacting genes: APP PDCD1 SRPK1
Entrez ID		5133	150681
HPRD ID		02590	17772
Ensembl ID		ENSG00000188389	ENSG00000178586
Uniprot IDs		A0A0M3M0G7 Q15116	Q8NGW1
PDB IDs		2M2D 3RRQ 4ZQK 5B8C 5GGR 5GGS 5IUS 5JXE 5WT9 6HIG 6J14 6J15 6JBT 6JJP 6K0Y 6R5G 6ROY 6ROZ 6UMT 6UMU 6UMV 6XKR 7BXA 7CGW 7CU5 7E9B 7VUX 7WSL 7WVM 8AS0 8EQ6 8GY5 8U31 8U32 9HK1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Negative Regulation Of Immune Response To Tumor Cell Regulation Of T Cell Mediated Immune Response To Tumor Cell Regulation Of Response To Tumor Cell Protein Modification By Small Protein Conjugation Negative Regulation Of T Cell Activation Negative Regulation Of T Cell Mediated Immunity Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Lymphocyte Activation Post-translational Protein Modification Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Activation Negative Regulation Of Adaptive Immune Response Protein Modification Process Endomembrane System Protein Ubiquitination Negative Regulation Of Cell Adhesion Negative Regulation Of Activated T Cell Proliferation Regulation Of T Cell Mediated Immunity Ubiquitin Protein Ligase Activity Regulation Of Protein Stability Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Proteolysis Negative Regulation Of Interleukin-10 Production Positive Regulation Of Leukocyte Proliferation Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Lymphocyte Mediated Immunity Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Immune System Process Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Immune Response Regulation Of Adaptive Immune Response Regulation Of Activated T Cell Proliferation Negative Regulation Of Type II Interferon Production Modification-dependent Protein Catabolic Process T Cell Costimulation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Metabolic Process Cellular Response To Nutrient Levels	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Immune Response Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulatory T Cell Apoptotic Process Negative Regulation Of Tolerance Induction Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Humoral Immune Response Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition External Side Of Plasma Membrane Immune System Process Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Positive Regulation Of Apoptotic Process Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding
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