PCOLCE and RELN

		PCOLCE	RELN
Description		procollagen C-endopeptidase enhancer	reelin
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Dendrite Extracellular Matrix Neuron Projection Reelin Complex
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Heparin Binding Peptidase Activator Activity	Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding Receptor Ligand Activity Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding
	Biological Process	Proteolysis Collagen Biosynthetic Process	Cell Morphogenesis Neuron Migration Proteolysis Cell Adhesion Axon Guidance Central Nervous System Development Brain Development Learning Long-term Memory Locomotory Behavior Associative Learning Glial Cell Differentiation Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Dendrite Development Cell Migration Spinal Cord Patterning Ventral Spinal Cord Development Hippocampus Development Cerebral Cortex Tangential Migration Layer Formation In Cerebral Cortex Cerebral Cortex Development Forebrain Development Positive Regulation Of TOR Signaling Protein Localization To Synapse Reelin-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Neuron Differentiation Response To Pain Regulation Of Behavior Modulation Of Chemical Synaptic Transmission Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Synaptic Activity Long-term Synaptic Potentiation Positive Regulation Of Dendritic Spine Morphogenesis Regulation Of Synapse Maturation Positive Regulation Of Synapse Maturation Postsynaptic Density Assembly NMDA Glutamate Receptor Clustering Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse Motor Neuron Migration Lateral Motor Column Neuron Migration Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Lateral Motor Column Neuron Migration Interneuron Migration Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Neuron Migration
Pathways		Collagen biosynthesis and modifying enzymes Crosslinking of collagen fibrils	Reelin signalling pathway
Drugs
Diseases			Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Resting heart rate ( 27798624) Subcortical volume (MOSTest) ( 32665545)	Adult body size ( 32376654) Alzheimer's disease ( 20452100) Bitter alcoholic beverage consumption ( 31046077) Body size at age 10 ( 32376654) Intraocular pressure ( 29785010) LDL levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Metabolite levels (Pyroglutamine) ( 23934736) Morning person ( 30696823) Multiple sclerosis (age of onset) ( 19010793) Night sleep phenotypes ( 27126917) Otosclerosis ( 19230858) Response to placebo treatment in childhood asthma (FVC change) ( 31557306) Schizophrenia ( 18282107) Sjögren's syndrome ( 28076899) Sucrose liking ( 31005972) Type 2 diabetes ( 30054458 30297969) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		6 interacting genes: COL2A1 COL3A1 ECT2 HMGB1 PLG RELN	11 interacting genes: DAB1 EFNB2 EFNB3 LRP8 PCDHA4 PCDHA6 PCOLCE RSPH1 SQSTM1 TRIP6 VLDLR
Entrez ID		5118	5649
HPRD ID		02603	02742
Ensembl ID		ENSG00000106333	ENSG00000189056
Uniprot IDs		Q15113	P78509
PDB IDs		1UAP 6FZV 6FZW 9EN2	8G21
Enriched GO Terms of Interacting Partners?		Fibrillar Collagen Trimer Extracellular Matrix Platelet-derived Growth Factor Binding Cell Differentiation Layer Formation In Cerebral Cortex Cellular Developmental Process Animal Organ Development Extracellular Space Extracellular Matrix Organization Regulation Of Cell Communication Extracellular Structure Organization Regulation Of Signaling Extracellular Matrix Structural Constituent Conferring Tensile Strength Regulation Of Small GTPase Mediated Signal Transduction Cell Migration Regulation Of Neuron Migration Extracellular Region Regulation Of Cell Migration Collagen Fibril Organization Chondrocyte Differentiation System Development Regulation Of Cell Motility Regulation Of Locomotion Cell Motility Positive Regulation Of Wound Healing Positive Regulation Of Blood Vessel Endothelial Cell Migration Collagen Trimer Collagen Type III Trimer Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Lateral Motor Column Neuron Migration Reelin Complex Spinal Cord Patterning Cerebral Cortex Development Lung Development Cartilage Development Protease Binding Mononuclear Cell Migration Anatomical Structure Morphogenesis Developmental Process Extracellular Matrix Structural Constituent Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Endothelial Cell Migration	Ventral Spinal Cord Development Reelin-mediated Signaling Pathway Nervous System Development Glutamatergic Synapse Reelin Receptor Activity Very-low-density Lipoprotein Particle Receptor Activity Regulation Of Neuron Projection Development System Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Developmental Process Regulation Of Cell Projection Organization Low-density Lipoprotein Particle Receptor Activity Positive Regulation Of Dendrite Development Apolipoprotein Binding Layer Formation In Cerebral Cortex Negative Regulation Of Neuron Projection Development Cell Adhesion Cargo Receptor Activity Ephrin Receptor Binding Adult Walking Behavior Negative Regulation Of Cell Projection Organization Walking Behavior Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell Projection Organization T Cell Costimulation Calcium Ion Binding Dendrite Morphogenesis Ephrin Receptor Signaling Pathway Negative Regulation Of Axonogenesis Cell Projection Morphogenesis Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Neuron Projection Morphogenesis Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission Ammon Gyrus Development Cell Surface Receptor Signaling Pathway Regulation Of Synapse Organization Hippocampus Development Cerebellum Structural Organization Adult Locomotory Behavior Positive Regulation Of Aorta Morphogenesis Virus Receptor Activity Calcium-dependent Protein Binding Brown Fat Cell Proliferation Amphisome Regulation Of Neurogenesis Cell Adhesion Molecule Binding Regulation Of Anatomical Structure Morphogenesis Regulation Of Dendrite Development Lateral Motor Column Neuron Migration Radial Glia Guided Migration Of Purkinje Cell
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