PCOLCE

Description		procollagen C-endopeptidase enhancer
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Heparin Binding Peptidase Activator Activity
	Biological Process	Proteolysis Collagen Biosynthetic Process
Pathways		Collagen biosynthesis and modifying enzymes Crosslinking of collagen fibrils
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Resting heart rate ( 27798624) Subcortical volume (MOSTest) ( 32665545)
Novel Interacting Genes		6 novel interacting genes: COL2A1 COL3A1 ECT2 HMGB1 PLG RELN
Interacting Genes		6 interacting genes: COL2A1 COL3A1 ECT2 HMGB1 PLG RELN
Entrez ID		5118
HPRD ID		02603
Ensembl ID		ENSG00000106333
Uniprot IDs		Q15113
PDB IDs		1UAP 6FZV 6FZW 9EN2
Enriched GO Terms of Interacting Partners?		Fibrillar Collagen Trimer Extracellular Matrix Platelet-derived Growth Factor Binding Cell Differentiation Layer Formation In Cerebral Cortex Cellular Developmental Process Animal Organ Development Extracellular Space Extracellular Matrix Organization Regulation Of Cell Communication Extracellular Structure Organization Regulation Of Signaling Extracellular Matrix Structural Constituent Conferring Tensile Strength Regulation Of Small GTPase Mediated Signal Transduction Cell Migration Regulation Of Neuron Migration Extracellular Region Regulation Of Cell Migration Collagen Fibril Organization Chondrocyte Differentiation System Development Regulation Of Cell Motility Regulation Of Locomotion Cell Motility Positive Regulation Of Wound Healing Positive Regulation Of Blood Vessel Endothelial Cell Migration Collagen Trimer Collagen Type III Trimer Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Lateral Motor Column Neuron Migration Reelin Complex Spinal Cord Patterning Cerebral Cortex Development Lung Development Cartilage Development Protease Binding Mononuclear Cell Migration Anatomical Structure Morphogenesis Developmental Process Extracellular Matrix Structural Constituent Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Endothelial Cell Migration
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