MYO15A and EPS8

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MYO15A	EPS8
Description		myosin XVA	EGFR pathway substrate 8, signaling adaptor
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GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Actin Cytoskeleton Membrane Myosin Complex Stereocilium Stereocilium Bundle Cell Projection Extracellular Exosome Actin-based Cell Projection	Cytoplasm Plasma Membrane Brush Border Cell Cortex Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Growth Cone Vesicle Stereocilium Stereocilium Bundle Stereocilium Tip Ruffle Membrane Cell Projection Neuron Projection Synapse Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Calmodulin Binding ATP Binding Actin Filament Binding	Actin Binding Protein Binding Small GTPase Binding
	Biological Process	Endocytosis Actin Filament Organization Sensory Perception Of Sound Locomotory Behavior Response To Light Stimulus Inner Ear Morphogenesis	Rho Protein Signal Transduction Adult Locomotory Behavior Regulation Of Cell Shape Exit From Mitosis Rac Protein Signal Transduction Actin Cytoskeleton Organization Regulation Of Actin Filament Length Regulation Of Rho Protein Signal Transduction Dendritic Cell Migration Behavioral Response To Ethanol Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Ruffle Assembly Cellular Response To Leukemia Inhibitory Factor
Pathways		Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases		Deafness, autosomal recessive
GWAS		Basal cell carcinoma ( 33549134) Change in neurofilament light levels ( 31295725) Haemorrhoidal disease ( 33888516) Hip index ( 34021172) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Obesity-related traits ( 23251661) Red blood cell count ( 32888494) Schizophrenia ( 25056061) Serum folate levels ( 29953918) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Metabolite levels ( 23823483) Protein quantitative trait loci ( 18464913)
Interacting Genes		4 interacting genes: EPS8 FASLG USP13 WHRN	63 interacting genes: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BORCS6 BYSL C19orf25 C6orf141 C8orf33 CASK CBL CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR ERBB3 GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 ITSN2 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RCAN3 RFXAP RSPH14 RUNX1T1 SCRN3 SERPINA5 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN TRIP11 USP6NL XAGE2 XRCC6 ZZZ3
Entrez ID		51168	2059
HPRD ID		04049	02563
Ensembl ID		ENSG00000091536	ENSG00000151491
Uniprot IDs		Q9UKN7	B4E3T6 Q12929
PDB IDs		6KZ1	2E8M 7TZK
Enriched GO Terms of Interacting Partners?		Stereocilium Bundle Stereocilium Tip Stereocilium Positive Regulation Of Phospholipid Translocation Cytoplasmic Vesicle Lumen Retinal Cell Programmed Cell Death Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Growth Cone Protein K29-linked Deubiquitination Maintenance Of Unfolded Protein BAT3 Complex Binding Protein K6-linked Deubiquitination Cerebellar Purkinje Cell Layer Formation Stereocilia Ankle Link Paranodal Junction Maintenance Stereocilia Ankle Link Complex USH2 Complex Periciliary Membrane Compartment Inflammatory Cell Apoptotic Process Actin Polymerization-dependent Cell Motility Necroptotic Signaling Pathway Intracellular Chloride Ion Homeostasis NMDA Selective Glutamate Receptor Complex Behavioral Response To Ethanol Neuron Projection Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Cellular Response To Cytokine Stimulus Positive Regulation Of Phospholipid Transport Endosomal Lumen Acidification Necroptotic Process Positive Regulation Of Ruffle Assembly Actin Crosslink Formation Exit From Mitosis Chloride Ion Homeostasis Regulation Of Plasma Membrane Organization Death Receptor Binding Barbed-end Actin Filament Capping Proteasome Binding Positive Regulation Of ERAD Pathway Melanocyte Differentiation K48-linked Deubiquitinase Activity Auditory Receptor Cell Stereocilium Organization Retina Homeostasis Programmed Necrotic Cell Death Monoatomic Anion Homeostasis Pigment Cell Differentiation Cell-cell Junction Maintenance Programmed Cell Death Involved In Cell Development Inner Ear Receptor Cell Differentiation	Epidermal Growth Factor Receptor Signaling Pathway Filopodium ERBB Signaling Pathway Protein Tyrosine Kinase Activator Activity Supramolecular Fiber Organization Actin Filament Organization Symbiont Entry Into Host Cell Ephrin Receptor Binding Actin Filament Bundle Organization Actin Filament Bundle Assembly Shc-EGFR Complex Focal Adhesion Enzyme-linked Receptor Protein Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Phosphotyrosine Residue Binding Biological Process Involved In Interaction With Host Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Developmental Process Schwann Cell Development Ruffle SH3 Domain Binding Cellular Response To Growth Factor Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus Epidermal Growth Factor Binding ERBB2 Signaling Pathway Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Response To Platelet-derived Growth Factor Neuregulin Binding Integrin Complex C-X3-C Chemokine Binding Cell Adhesion Mediated By Integrin Response To Growth Factor Wound Healing, Spreading Of Cells Response To Activity Neurotrophin TRKA Receptor Binding Endocytosis Insulin Receptor Signaling Pathway Integrin Binding Virus Receptor Activity Insulin-like Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Binding Heterotypic Cell-cell Adhesion Actin-based Cell Projection Cellular Developmental Process Import Into Cell Schaffer Collateral - CA1 Synapse Ruffle Membrane Integrin-mediated Signaling Pathway Lamellipodium
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