EPS8 and NACC2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		EPS8	NACC2
Description		EGFR pathway substrate 8, signaling adaptor	NACC family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Brush Border Cell Cortex Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Growth Cone Vesicle Stereocilium Stereocilium Bundle Stereocilium Tip Ruffle Membrane Cell Projection Neuron Projection Synapse Extracellular Exosome Glutamatergic Synapse	Chromatin Nucleus Nucleolus Mitochondrion Nuclear Lumen
	Molecular Function	Actin Binding Protein Binding Small GTPase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Protein-containing Complex Binding
	Biological Process	Rho Protein Signal Transduction Adult Locomotory Behavior Regulation Of Cell Shape Exit From Mitosis Rac Protein Signal Transduction Actin Cytoskeleton Organization Regulation Of Actin Filament Length Regulation Of Rho Protein Signal Transduction Dendritic Cell Migration Behavioral Response To Ethanol Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Ruffle Assembly Cellular Response To Leukemia Inhibitory Factor	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Protein-containing Complex Localization Regulation Of Cell Population Proliferation Negative Regulation Of DNA-templated Transcription Protein Homooligomerization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways		Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Protein quantitative trait loci ( 18464913)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Sjögren's syndrome ( 28076899) Ulcerative colitis ( 28067908)
Interacting Genes		63 interacting genes: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BORCS6 BYSL C19orf25 C6orf141 C8orf33 CASK CBL CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR ERBB3 GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 ITSN2 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RCAN3 RFXAP RSPH14 RUNX1T1 SCRN3 SERPINA5 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN TRIP11 USP6NL XAGE2 XRCC6 ZZZ3	5 interacting genes: EPS8 HDAC2 MTA1 MTA2 MTA3
Entrez ID		2059	138151
HPRD ID		02563	09831
Ensembl ID		ENSG00000151491	ENSG00000148411
Uniprot IDs		B4E3T6 Q12929	Q96BF6
PDB IDs		2E8M 7TZK
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway Filopodium ERBB Signaling Pathway Protein Tyrosine Kinase Activator Activity Supramolecular Fiber Organization Actin Filament Organization Symbiont Entry Into Host Cell Ephrin Receptor Binding Actin Filament Bundle Organization Actin Filament Bundle Assembly Shc-EGFR Complex Focal Adhesion Enzyme-linked Receptor Protein Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Phosphotyrosine Residue Binding Biological Process Involved In Interaction With Host Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Developmental Process Schwann Cell Development Ruffle SH3 Domain Binding Cellular Response To Growth Factor Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus Epidermal Growth Factor Binding ERBB2 Signaling Pathway Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Response To Platelet-derived Growth Factor Neuregulin Binding Integrin Complex C-X3-C Chemokine Binding Cell Adhesion Mediated By Integrin Response To Growth Factor Wound Healing, Spreading Of Cells Response To Activity Neurotrophin TRKA Receptor Binding Endocytosis Insulin Receptor Signaling Pathway Integrin Binding Virus Receptor Activity Insulin-like Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Binding Heterotypic Cell-cell Adhesion Actin-based Cell Projection Cellular Developmental Process Import Into Cell Schaffer Collateral - CA1 Synapse Ruffle Membrane Integrin-mediated Signaling Pathway Lamellipodium	NuRD Complex Regulation Of Cell Fate Specification Regulation Of Cell Fate Commitment Regulation Of Stem Cell Differentiation Histone Deacetylase Binding Behavioral Response To Ethanol Chromatin Binding Chromatin Remodeling Histone Deacetylase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Corepressor Activity Chromatin Organization Epigenetic Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Nucleosomal DNA Binding Transcription Coactivator Activity Regulation Of Developmental Process Histone Deacetylase Complex Circadian Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Male Mating Behavior Positive Regulation Of Granulosa Cell Proliferation Granulosa Cell Proliferation Regulation Of Cell Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Protein De-2-hydroxyisobutyrylase Activity Circadian Rhythm Mitotic Cell Cycle Phase Transition Adult Behavior Cell Cycle Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Lysine Delactylase Activity Fungiform Papilla Formation Positive Regulation Of Protein Autoubiquitination Negative Regulation Of Gene Expression, Epigenetic Chromosome, Telomeric Region DNA-binding Transcription Factor Binding Protein Decrotonylase Activity Histone Decrotonylase Activity Locomotory Behavior Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Hair Follicle Placode Formation Regulation Of Protein Autoubiquitination
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