MLXIPL and CLCC1

		MLXIPL	CLCC1
Description		MLX interacting protein like	chloride channel CLIC like 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Chloride Channel Complex Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Carbohydrate Response Element Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding	Chloride Channel Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Lipid Biosynthetic Process Anatomical Structure Morphogenesis Glucose Mediated Signaling Pathway Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Glucose Homeostasis Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Glycolytic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Lipid Biosynthetic Process Fatty Acid Homeostasis Triglyceride Homeostasis Negative Regulation Of Oxidative Phosphorylation Energy Homeostasis Negative Regulation Of Signal Transduction By P53 Class Mediator	Monoatomic Ion Transport Chloride Transport Endoplasmic Reticulum Calcium Ion Homeostasis Monoatomic Ion Transmembrane Transport Chloride Transmembrane Transport
Pathways		PKA-mediated phosphorylation of key metabolic factors PKA-mediated phosphorylation of key metabolic factors AMPK inhibits chREBP transcriptional activation activity ChREBP activates metabolic gene expression ChREBP activates metabolic gene expression PP2A-mediated dephosphorylation of key metabolic factors
Drugs
Diseases
GWAS		A body shape index ( 34021172) Alanine aminotransferase levels ( 33547301) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein B levels ( 32203549) Birth weight ( 27680694 31043758) Bitter alcoholic beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Coffee consumption ( 31046077 31959922) Coffee consumption (cups per day) ( 25288136 31837886) Eosinophil percentage of white cells ( 32888494) Factor VII activity ( 30642921) Gamma glutamyl transferase levels ( 29403010 33339817) Glycated hemoglobin levels ( 34059833) HDL cholesterol ( 20686565 24097068 30275531) HDL cholesterol levels ( 28334899 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Hypertriglyceridemia ( 20657596 23505323 27599772) Immature fraction of reticulocytes ( 32888494) Lamb consumption ( 32066663) LDL levels x fish oil supplementation interaction (1df) ( 33760818) LDL levels x fish oil supplementation interaction (2df) ( 33760818) Lipid metabolism phenotypes ( 22286219) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514) Low density lipoprotein cholesterol levels ( 32154731) Malaria ( 31844061) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Meat-related diet ( 32066663) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 22399527) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Non-oily fish consumption ( 32066663) Platelet count ( 27863252) Platelet distribution width ( 32888494) Postprandial triglyceride levels ( 32603185) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Serum albumin levels ( 29403010) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Serum uric acid levels ( 29403010 30993211) Total cholesterol levels ( 30275531) Total triglycerides levels ( 26690388) Triglyceride levels ( 28334899 29403010 30698716 31087446 32154731 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 18193043 18193044 18193046 19060906 19060911 20686565 20864672 21909109 24097068 25961943 26160806 26582766 30275531) Urate levels ( 23263486 31578528) Urinary sodium excretion ( 31409800) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) White blood cell count ( 32888494)	Fat distribution (HIV) ( 21897333) Recurrent major depressive disorder ( 29317602)
Interacting Genes		6 interacting genes: CIT CLCC1 EP300 GRB2 MLX NIF3L1	8 interacting genes: GHR GPSM2 LAMTOR5 LRIF1 MLXIPL OGT SLC25A24 WDR47
Entrez ID		51085	23155
HPRD ID		12033	17471
Ensembl ID		ENSG00000009950	ENSG00000121940
Uniprot IDs		Q9NP71	A0A6Q8PG14 Q96S66
PDB IDs		6MJL 6YGJ 8BTQ 8BWE 8BWH 8C1Y
Enriched GO Terms of Interacting Partners?		RNA Polymerase II-specific DNA-binding Transcription Factor Binding Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Transcription Coactivator Binding Endodermal Cell Differentiation Guanyl-nucleotide Exchange Factor Adaptor Activity Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity SH3 Domain Binding Grb2-EGFR Complex N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Peptide Lactyltransferase (CoA-dependent) Activity Negative Regulation Of Protein Oligomerization Cellular Response To Radiation	Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription By Glucose Cellular Response To Nutrient Regulation Of Glycolytic Process Protein Localization To Lysosome Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Carbohydrate Catabolic Process Positive Regulation Of TORC1 Signaling Regulation Of Protein Localization TORC1 Signaling Detection Of Hot Stimulus Involved In Thermoception Carbohydrate Response Element Binding Regulation Of ATP Metabolic Process TOR Signaling Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of TOR Signaling Growth Hormone Receptor Activity Protein Localization To Vacuole Positive Regulation Of Lipid Biosynthetic Process Regulation Of TORC1 Signaling Positive Regulation Of Protein Localization Lateral Cell Cortex ADP:phosphate Antiporter Activity Response To Nutrient Levels Growth Hormone Receptor Complex Protein O-acetylglucosaminyltransferase Activity Cell Cortex Region ATP:phosphate Antiporter Activity Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Lipid Metabolic Process Adenine Nucleotide Transmembrane Transporter Activity Response To Cycloheximide Response To Insulin Regulation Of TOR Signaling Non-canonical Inflammasome Complex Assembly Regulation Of Protein Localization To Cell Periphery Protein Localization To Organelle Response To Nutrient Ragulator Complex Detection Of Temperature Stimulus Involved In Thermoception Regulation Of Microtubule Cytoskeleton Organization Anterior Commissure Morphogenesis Maintenance Of Centrosome Location Positive Regulation Of Protein Localization To Cell Cortex Glucose Mediated Signaling Pathway Regulation Of Biological Quality
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