MLXIPL and CIT

		MLXIPL	CIT
Description		MLX interacting protein like	citron rho-interacting serine/threonine kinase
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol	Cytoplasm Cytosol Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Carbohydrate Response Element Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding	Nucleotide Binding Transcription Coactivator Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity SH3 Domain Binding Protein Kinase Binding PDZ Domain Binding Protein Serine/threonine Kinase Inhibitor Activity Metal Ion Binding Scaffold Protein Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Lipid Biosynthetic Process Anatomical Structure Morphogenesis Glucose Mediated Signaling Pathway Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Glucose Homeostasis Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Glycolytic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Lipid Biosynthetic Process Fatty Acid Homeostasis Triglyceride Homeostasis Negative Regulation Of Oxidative Phosphorylation Energy Homeostasis Negative Regulation Of Signal Transduction By P53 Class Mediator	Mitotic Cell Cycle Mitotic Cytokinesis Nervous System Development Cell Differentiation Positive Regulation Of Cytokinesis Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Hippo Signaling Generation Of Neurons Cell Division Neuron Apoptotic Process
Pathways		PKA-mediated phosphorylation of key metabolic factors PKA-mediated phosphorylation of key metabolic factors AMPK inhibits chREBP transcriptional activation activity ChREBP activates metabolic gene expression ChREBP activates metabolic gene expression PP2A-mediated dephosphorylation of key metabolic factors	RHO GTPases activate CIT RHO GTPases activate CIT RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS		A body shape index ( 34021172) Alanine aminotransferase levels ( 33547301) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein B levels ( 32203549) Birth weight ( 27680694 31043758) Bitter alcoholic beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Coffee consumption ( 31046077 31959922) Coffee consumption (cups per day) ( 25288136 31837886) Eosinophil percentage of white cells ( 32888494) Factor VII activity ( 30642921) Gamma glutamyl transferase levels ( 29403010 33339817) Glycated hemoglobin levels ( 34059833) HDL cholesterol ( 20686565 24097068 30275531) HDL cholesterol levels ( 28334899 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Hypertriglyceridemia ( 20657596 23505323 27599772) Immature fraction of reticulocytes ( 32888494) Lamb consumption ( 32066663) LDL levels x fish oil supplementation interaction (1df) ( 33760818) LDL levels x fish oil supplementation interaction (2df) ( 33760818) Lipid metabolism phenotypes ( 22286219) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514) Low density lipoprotein cholesterol levels ( 32154731) Malaria ( 31844061) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Meat-related diet ( 32066663) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 22399527) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Non-oily fish consumption ( 32066663) Platelet count ( 27863252) Platelet distribution width ( 32888494) Postprandial triglyceride levels ( 32603185) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Serum albumin levels ( 29403010) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Serum uric acid levels ( 29403010 30993211) Total cholesterol levels ( 30275531) Total triglycerides levels ( 26690388) Triglyceride levels ( 28334899 29403010 30698716 31087446 32154731 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 18193043 18193044 18193046 19060906 19060911 20686565 20864672 21909109 24097068 25961943 26160806 26582766 30275531) Urate levels ( 23263486 31578528) Urinary sodium excretion ( 31409800) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) White blood cell count ( 32888494)	Mitochondrial heteroplasmy measurement ( 33731350) Number of sexual partners ( 30643258) Urgency urinary incontinence ( 25524241)
Interacting Genes		6 interacting genes: CIT CLCC1 EP300 GRB2 MLX NIF3L1	18 interacting genes: ABCB9 CEBPA DERA DISC1 DLG4 DSCAM ENPP7 GRIN1 GRIN2D HIP1R MLXIPL MTNR1A RAC1 RHOA RHOB RHOC RND3 SELPLG
Entrez ID		51085	11113
HPRD ID		12033	09289
Ensembl ID		ENSG00000009950	ENSG00000122966
Uniprot IDs		Q9NP71	O14578
PDB IDs		6MJL 6YGJ 8BTQ 8BWE 8BWH 8C1Y
Enriched GO Terms of Interacting Partners?		RNA Polymerase II-specific DNA-binding Transcription Factor Binding Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Transcription Coactivator Binding Endodermal Cell Differentiation Guanyl-nucleotide Exchange Factor Adaptor Activity Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity SH3 Domain Binding Grb2-EGFR Complex N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Peptide Lactyltransferase (CoA-dependent) Activity Negative Regulation Of Protein Oligomerization Cellular Response To Radiation	Actin Filament Organization Regulation Of Neuronal Synaptic Plasticity Intracellular Signaling Cassette Skeletal Muscle Satellite Cell Migration Intracellular Signal Transduction Cerebral Cortex Cell Migration Signal Transduction Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Small GTPase-mediated Signal Transduction Supramolecular Fiber Organization Telencephalon Cell Migration Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Lipase Activity Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cleavage Furrow Positive Regulation Of Stress Fiber Assembly Forebrain Cell Migration Cell Adhesion Regulation Of System Process Apical Junction Assembly GTPase Activity GTP Binding Dendritic Spine Glutamatergic Synapse Negative Regulation Of Oxidative Phosphorylation Synapse Protein-containing Complex Binding Glutamate Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission NMDA Glutamate Receptor Activity Glutamate Binding Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Multicellular Organismal Process Regulation Of Actin Filament-based Process Negative Regulation Of Cellular Respiration NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Synaptic Membrane Mitotic Cytokinesis Excitatory Chemical Synaptic Transmission Positive Regulation Of Protein-containing Complex Assembly Regulation Of Synaptic Plasticity Regulation Of Synaptic Transmission, Glutamatergic
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