CELA2B and ZDHHC15

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CELA2B	ZDHHC15
Description		chymotrypsin like elastase 2B	zDHHC palmitoyltransferase 15
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Postsynaptic Density Membrane Synapse Postsynapse
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Protein Binding Zinc Ion Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Metal Ion Binding Protein-cysteine S-stearoyltransferase Activity
	Biological Process	Proteolysis	Protein Targeting To Membrane Synaptic Vesicle Maturation Peptidyl-L-cysteine S-palmitoylation Establishment Of Protein Localization Regulation Of Dendritic Spine Morphogenesis Protein Localization To Postsynapse Protein Localization To Membrane Protein Targeting To Golgi Apparatus Positive Regulation Of Dendrite Development
Pathways
Drugs
Diseases			Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Alcoholic chronic pancreatitis ( 28754779) Body mass index ( 29273807) Body size at age 10 ( 32376654) Estimated glomerular filtration rate ( 31015462) Hemoglobin ( 32888494) Resistant hypertension ( 30237584)
Interacting Genes		6 interacting genes: CALCOCO2 KAZN KRT40 KRTAP3-1 PDPN ZDHHC15	49 interacting genes: ADCYAP1R1 ARL13B BNIP3 C14orf180 CD79A CELA2B CERCAM CFTR CLEC10A CLRN1 CREB3L1 CYB5R3 DHRSX ERGIC3 FAM241B GIMAP1 GOLGA7B GPR152 LEMD1 LEPROTL1 LHFPL5 LMNA LSMEM1 MCEMP1 MTIF3 ORMDL1 ORMDL2 PEX16 PLLP PRAF2 PVR RUSF1 SLC10A6 SMIM1 SNORC STX3 TBXA2R TMEFF2 TMEM120B TMEM128 TMEM14C TMEM222 TMEM42 TMEM52B TNFRSF10B TSNARE1 TUFM VAPB YIPF4
Entrez ID		51032	158866
HPRD ID		06496	06758
Ensembl ID		ENSG00000215704	ENSG00000102383
Uniprot IDs		P08218 Q6ISP9	B3KY34 Q96MV8
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Myofibroblast Contraction Folic Acid Transmembrane Transporter Activity Leading Edge Of Lamellipodium Lymphatic Endothelial Cell Fate Commitment Water Transmembrane Transporter Activity Keratin Filament Structural Molecule Activity Intermediate Filament Protein-cysteine S-myristoyltransferase Activity Protein Targeting To Golgi Apparatus Xenophagy Positive Regulation Of Autophagosome Maturation Chemokine Binding Protein-cysteine S-stearoyltransferase Activity Folic Acid Transport Synaptic Vesicle Maturation Positive Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Platelet Aggregation Regulation Of Lamellipodium Morphogenesis Tetraspanin-enriched Microdomain Epithelial Cell Fate Commitment Peptidyl-L-cysteine S-palmitoylation Positive Regulation Of Cellular Component Organization Regulation Of Autophagosome Maturation Lymphangiogenesis Water Channel Activity Positive Regulation Of Dendrite Development Positive Regulation Of Homotypic Cell-cell Adhesion Lymph Node Development Filopodium Membrane Protein Palmitoylation Palmitoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity	Membrane Membrane Docking Organelle Localization By Membrane Tethering Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Protein Binding Negative Regulation Of Sphingolipid Biosynthetic Process Serine Palmitoyltransferase Complex
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