ZDHHC15 and TMEM120B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZDHHC15	TMEM120B
Description		zDHHC palmitoyltransferase 15	transmembrane protein 120B
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Postsynaptic Density Membrane Synapse Postsynapse	Nucleus Nuclear Inner Membrane Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Metal Ion Binding Protein-cysteine S-stearoyltransferase Activity	Monoatomic Ion Channel Activity Protein Binding
	Biological Process	Protein Targeting To Membrane Synaptic Vesicle Maturation Peptidyl-L-cysteine S-palmitoylation Establishment Of Protein Localization Regulation Of Dendritic Spine Morphogenesis Protein Localization To Postsynapse Protein Localization To Membrane Protein Targeting To Golgi Apparatus Positive Regulation Of Dendrite Development	Fat Cell Differentiation Protein Heterooligomerization
Pathways
Drugs
Diseases		Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS			HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 24026423 27863252 32888494) Mean reticulocyte volume ( 32888494) Molybdenum levels ( 26025379) Neutrophil count ( 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) White blood cell count ( 32888494)
Interacting Genes		49 interacting genes: ADCYAP1R1 ARL13B BNIP3 C14orf180 CD79A CELA2B CERCAM CFTR CLEC10A CLRN1 CREB3L1 CYB5R3 DHRSX ERGIC3 FAM241B GIMAP1 GOLGA7B GPR152 LEMD1 LEPROTL1 LHFPL5 LMNA LSMEM1 MCEMP1 MTIF3 ORMDL1 ORMDL2 PEX16 PLLP PRAF2 PVR RUSF1 SLC10A6 SMIM1 SNORC STX3 TBXA2R TMEFF2 TMEM120B TMEM128 TMEM14C TMEM222 TMEM42 TMEM52B TNFRSF10B TSNARE1 TUFM VAPB YIPF4	61 interacting genes: ALOX5AP ANKS6 APOA5 AQP6 AQP8 ARL13B BNIP3L CCNDBP1 CD74 COMT CPLX4 CREB3L1 DNAH10 EBP ERGIC3 FCER1G FFAR2 FKBP7 GAD2 GJB1 GORAB GPR152 GPRC5D GPX8 HSD17B11 HSD17B13 IFNGR2 IL7R JAGN1 JPH1 KCNJ6 LMNA LRRTM2 MGST3 MRPS18B MTRFR MUC1 NCAPH2 REEP2 REEP4 RETREG3 RNF19B RNF5 SCN3B SH3GL3 SLC10A1 SLC10A6 SLC17A8 SLC18A1 SLC1A3 SLC35H1 STOM STX2 TLCD4 TMEM139 TMEM143 TMEM14B TMEM80 TMPRSS2 TMX2 ZDHHC15
Entrez ID		158866	144404
HPRD ID		06758	19119
Ensembl ID		ENSG00000102383	ENSG00000188735
Uniprot IDs		B3KY34 Q96MV8	A0PK00
PDB IDs			7F73
Enriched GO Terms of Interacting Partners?		Membrane Membrane Docking Organelle Localization By Membrane Tethering Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Protein Binding Negative Regulation Of Sphingolipid Biosynthetic Process Serine Palmitoyltransferase Complex	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Protein Binding Organic Hydroxy Compound Transport Steroid Dehydrogenase Activity Glutathione Peroxidase Activity Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Organization Leukotriene-C4 Synthase Activity Bile Acid:sodium Symporter Activity Transmembrane Transport Monoamine Transport Leukocyte Mediated Immunity Gamma-aminobutyric Acid Biosynthetic Process Prostanoid Metabolic Process Neurotransmitter Loading Into Synaptic Vesicle Regulation Of Transport Norepinephrine Transport Gamma-aminobutyric Acid Metabolic Process Icosanoid Metabolic Process Ammonium Channel Activity Neurotransmitter Transport Symporter Activity Icosanoid Biosynthetic Process Ammonium Transmembrane Transport Cellular Response To Cocaine Cellular Detoxification Negative Regulation Of Peptide Secretion Amine Transport Cytokine Receptor Activity Serotonin Transport L-glutamate Transmembrane Transporter Activity Lymphocyte Mediated Immunity Non-motile Cilium Assembly Nuclear Envelope Water Channel Activity Negative Regulation Of Leukocyte Apoptotic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?