VPS36 and SNF8

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (biochemical)
HPRD (in vivo)

		VPS36	SNF8
Description		vacuolar protein sorting 36 homolog	SNF8 subunit of ESCRT-II
Image
GO Annotations	Cellular Component	ESCRT II Complex Nucleus Cytoplasm Lysosome Endosome Late Endosome Cytosol Membrane Late Endosome Membrane Extracellular Exosome	ESCRT II Complex Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Late Endosome Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome
	Molecular Function	Protein Binding Lipid Binding Phosphatidylinositol-3-phosphate Binding Ubiquitin Binding	Protein Binding Lipid Binding Channel Regulator Activity Protein Homodimerization Activity
	Biological Process	Protein Transport Macroautophagy Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Fission	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Protein Transport Macroautophagy Endocytic Recycling Multivesicular Body Assembly Regulation Of Protein Catabolic Process Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of MAP Kinase Activity Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Regulation Of Protein Complex Stability Multivesicular Body Sorting Pathway Membrane Fission Positive Regulation Of Exosomal Secretion
Pathways		Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events	Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events
Drugs
Diseases
GWAS		Lewy body disease ( 25188341)	Coronary heart disease ( 21378990) Hip circumference adjusted for BMI ( 34021172) Type 2 diabetes ( 29358691)
Interacting Genes		8 interacting genes: CHMP6 RILP SNCA SNF8 SPRY2 TSG101 UBC VPS25	26 interacting genes: ADORA1 AKAP9 CHMP6 CLP1 CT55 DVL2 ELL FANCL GLYCTK GOLGA2 HMOX1 KDM1A NIF3L1 PRMT6 RILP SMARCD1 SUOX SUV39H2 TRIM54 TSG101 TXLNA UBC VAC14 VPS25 VPS36 YWHAE
Entrez ID		51028	11267
HPRD ID		12620	16847
Ensembl ID		ENSG00000136100	ENSG00000159210
Uniprot IDs		Q86VN1	Q96H20
PDB IDs		2HTH 2ZME 3CUQ	2ZME 3CUQ
Enriched GO Terms of Interacting Partners?		Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Endosome Organization Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization Multivesicular Body Assembly Late Endosome To Vacuole Transport Membrane Fission Vacuolar Transport Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Signaling Receptor Activity Regulation Of ERBB Signaling Pathway Regulation Of Phosphorus Metabolic Process Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Protein Metabolic Process Endosomal Transport Regulation Of Exosomal Secretion Endosome Membrane Membrane Organization Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Tyrosine Kinase Activity Vesicle Organization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Establishment Of Localization In Cell Negative Regulation Of ERBB Signaling Pathway Regulation Of Signaling Receptor Activity Late Endosome Membrane Regulation Of Phosphorylation Macroautophagy ESCRT II Complex Regulation Of Exocytosis Vesicle-mediated Transport Regulation Of Protein Kinase Activity Establishment Of Protein Localization To Vacuole Regulation Of Kinase Activity Regulation Of Protein Modification Process Negative Regulation Of Protein Kinase Activity Negative Regulation Of Kinase Activity Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Exocytosis Autophagy Organelle Assembly Endosome Protein Localization To Vacuole Organelle Organization Negative Regulation Of Protein Phosphorylation	Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization Endosome Organization Multivesicular Body Assembly Late Endosome To Vacuole Transport Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Membrane Fission Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Signaling Receptor Activity Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Late Endosome Membrane Negative Regulation Of Peptidyl-tyrosine Phosphorylation Macroautophagy Vacuolar Transport Regulation Of Protein Tyrosine Kinase Activity ESCRT II Complex Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Signaling Receptor Activity Vesicle-mediated Transport Endosomal Transport Endosome Membrane Autophagy Vesicle Organization Establishment Of Protein Localization To Vacuole Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Kinase Activity Regulation Of ERBB Signaling Pathway Negative Regulation Of Kinase Activity Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Catabolic Process Negative Regulation Of Metabolic Process Protein Localization To Vacuole Regulation Of Exosomal Secretion Establishment Of Protein Localization Viral Budding Via Host ESCRT Complex Organelle Assembly Negative Regulation Of Protein Phosphorylation Histone H3 Methyltransferase Activity Viral Budding Regulation Of Signal Transduction By P53 Class Mediator Endosome Viral Release From Host Cell Negative Regulation Of Phosphorylation Lysosomal Transport Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Microtubule Nucleation Ubiquitin Protein Ligase Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?