GLRX2 and DCXR

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GLRX2	DCXR
Description		glutaredoxin 2	dicarbonyl and L-xylulose reductase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion	Nucleus Mitochondrion Cytosol Cytoplasmic Microtubule Plasma Membrane Microvillus Brush Border Membrane Extracellular Exosome
	Molecular Function	Protein Disulfide Isomerase Activity Protein Binding Arsenate Reductase (glutaredoxin) Activity Electron Transfer Activity Protein-disulfide Reductase Activity Glutathione Disulfide Oxidoreductase Activity Metal Ion Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding	Carbonyl Reductase (NADPH) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On CH-OH Group Of Donors Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Identical Protein Binding L-xylulose Reductase (NADPH) Activity
	Biological Process	Regulation Of DNA-templated Transcription Glutathione Metabolic Process Apoptotic Process Response To Temperature Stimulus Regulation Of Signal Transduction Cell Differentiation DNA Protection Cell Redox Homeostasis Response To Redox State	Xylulose Metabolic Process Glucose Metabolic Process NADP+ Metabolic Process D-glucuronate Catabolic Process To D-xylulose 5-phosphate D-xylose Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Formation of xylulose-5-phosphate Essential pentosuria
Drugs		Glutathione	Dihydrogenphosphate Nicotinamide adenine dinucleotide phosphate
Diseases			Pentosuria
GWAS			Refractive error ( 32231278)
Interacting Genes		6 interacting genes: DCXR DENND1B ELF5 FBXO7 NUTF2 TXNRD1	5 interacting genes: APP CEBPA CRADD GLRX2 RPTOR
Entrez ID		51022	51181
HPRD ID		12112	16320
Ensembl ID		ENSG00000023572	ENSG00000169738
Uniprot IDs		Q9NS18	A0A384NY14 Q7Z4W1
PDB IDs		2CQ9 2FLS 2HT9	1PR9 1WNT 3D3W
Enriched GO Terms of Interacting Partners?		NADPH Peroxidase Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite L-xylulose Reductase (NADPH) Activity Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Ectodermal Cell Fate Commitment Xylulose Metabolic Process Protein Localization To Nuclear Pore Lewy Body Core D-xylose Metabolic Process Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, NAD(P) As Acceptor Oxidoreductase Activity, Acting On CH-OH Group Of Donors D-glucuronate Catabolic Process D-glucuronate Catabolic Process To D-xylulose 5-phosphate Nuclear Pore Central Transport Channel Thioredoxin-disulfide Reductase (NADPH) Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Carbonyl Reductase (NADPH) Activity Positive Regulation Of T-helper 2 Cell Cytokine Production Pentose Metabolic Process	Positive Regulation Of Glycolytic Process Positive Regulation Of ATP Metabolic Process Regulation Of Glycolytic Process Homeostatic Process Regulation Of Carbohydrate Catabolic Process Amyloid-beta Complex Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Response To Stress Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Toll Signaling Pathway RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Arsenate Reductase (glutaredoxin) Activity Positive Regulation Of Catabolic Process Cellular Response To Stress Notch Signaling Pathway Acetylcholine Receptor Activator Activity Positive Regulation Of Mitotic Cell Cycle Intracellular Signal Transduction Cellular Homeostasis Lipoprotein Particle Memory Positive Regulation Of Protein Import Regulation Of Generation Of Precursor Metabolites And Energy Response To Vitamin B2 C/EBP Complex Glutathione Disulfide Oxidoreductase Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Cell Maturation Positive Regulation Of Endothelin Production Positive Regulation Of Apoptotic Signaling Pathway Growth Cone Filopodium Positive Regulation Of Small Molecule Metabolic Process Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization CHOP-C/EBP Complex Death Domain Binding Endopeptidase Complex Positive Regulation Of Proteolysis Apoptotic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Chemical Homeostasis Intermediate-density Lipoprotein Particle
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