NOVA1

Description		NOVA alternative splicing regulator 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Sequence-specific MRNA Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing Nervous System Development RNA Splicing Regulation Of RNA Metabolic Process Negative Regulation Of Cold-induced Thermogenesis
Pathways
Drugs
Diseases
GWAS		BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 28892062) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Cognitive decline rate in late mild cognitive impairment ( 26252872) Eosinophilic esophagitis ( 25407941) Finger osteoarthritis severity (hand Klsum) ( 33055079) Hand grip strength ( 29691431) Metabolite levels ( 23823483) Migraine ( 27182965) Neuritic plaque ( 31497858) Overweight status ( 25133637) Peanut allergy ( 29030101) Plasma anti-thyroid peroxidase levels ( 29678681) Zinc levels ( 26025379)
Novel Interacting Genes		6 novel interacting genes: APP PCBP1 RNF10 RPP14 SMARCC2 SRPK1
Interacting Genes		6 interacting genes: APP PCBP1 RNF10 RPP14 SMARCC2 SRPK1
Entrez ID		4857
HPRD ID		03693
Ensembl ID		ENSG00000139910
Uniprot IDs		B7Z770 P51513
PDB IDs		1DT4 2ANN 2ANR
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of RNA Metabolic Process Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Regulation Of Nervous System Process Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of DNA-templated Transcription Low-density Lipoprotein Particle Mediated Signaling Sequence-specific Single Stranded DNA Binding Nuclear Matrix Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Endoribonuclease Complex Ribonuclease P Complex Regulation Of Spontaneous Synaptic Transmission Chromatin Organization NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Axon Choice Point Recognition Regulation Of Nucleobase-containing Compound Metabolic Process Viral RNA Genome Replication Nucleus Heparan Sulfate Binding Signaling Receptor Activator Activity
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