PC and SERPINH1

		PC	SERPINH1
Description		pyruvate carboxylase	serpin family H member 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol	Extracellular Space Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Extracellular Matrix Membrane Raft
	Molecular Function	Nucleotide Binding Catalytic Activity Pyruvate Carboxylase Activity Protein Binding ATP Binding Biotin Binding Ligase Activity Identical Protein Binding Metal Ion Binding	RNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Collagen Binding Unfolded Protein Binding
	Biological Process	Gluconeogenesis Lipid Metabolic Process NADP+ Metabolic Process Negative Regulation Of Gene Expression Viral RNA Genome Packaging Viral Release From Host Cell NAD+ Metabolic Process Small Molecule Metabolic Process Host-mediated Activation Of Viral Process	Chondrocyte Development Involved In Endochondral Bone Morphogenesis Response To Unfolded Protein Collagen Fibril Organization Collagen Biosynthetic Process Protein Maturation
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Gluconeogenesis Pyruvate metabolism	Collagen biosynthesis and modifying enzymes
Drugs		Pyruvic acid Biotin 5-(hexahydro-2-oxo-1H-thieno[3,4-D]imidazol-6-yl)pentanal
Diseases		Pyruvate carboxylase deficiency
GWAS		A body shape index ( 34021172) Bipolar disorder ( 21926972 31043756 34002096) Familial squamous cell lung carcinoma ( 29924316) Hip circumference adjusted for BMI ( 34021172) HIV-1 susceptibility ( 22174851) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)	A body shape index ( 34021172) Coronary artery disease ( 33020668 29212778) Height ( 22021425 33713608 31562340 28552196 28270201 25429064 25282103 20881960) Hip circumference adjusted for BMI ( 25673412 34021172) Myocardial infarction ( 33532862) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 34021172)
Interacting Genes		10 interacting genes: FNDC3B GOT1 GOT2 LCOR MDH2 MYO7A PCBP2 RNF10 SERPINH1 USP7	21 interacting genes: BAG6 BRCA2 C1QL3 CD9 CDK9 CEP70 COL26A1 ESR2 FEZ1 H1-5 KAT2B KLF13 LINC01554 NSG2 OGT PC PPARG SLC2A4 SLC35F6 UBQLN4 UBTF
Entrez ID		5091	871
HPRD ID		02032	02968
Ensembl ID		ENSG00000173599	ENSG00000149257
Uniprot IDs		P11498	A8K259 P50454
PDB IDs		3BG3 3BG9 7WTA 7WTB 7WTC 7WTD 7WTE 8HWL 8J7O 8XL9
Enriched GO Terms of Interacting Partners?		Malate-aspartate Shuttle L-glutamate Catabolic Process To Aspartate L-aspartate:2-oxoglutarate Aminotransferase Activity Aspartate Biosynthetic Process L-aspartate Catabolic Process NAD+ Metabolic Process Aspartate Metabolic Process Oxaloacetate Metabolic Process L-glutamate Catabolic Process Dicarboxylic Acid Metabolic Process Nicotinamide Nucleotide Metabolic Process 2-oxoglutarate Metabolic Process Dicarboxylic Acid Catabolic Process Transaminase Activity Glutamate Metabolic Process Aspartate Family Amino Acid Metabolic Process Pyridoxal Phosphate Binding Gluconeogenesis Hexose Biosynthetic Process Glutamine Family Amino Acid Metabolic Process L-glutamate Biosynthetic Process L-malate Dehydrogenase (NADP+) Activity Upper Tip-link Density Myosin VII Complex Amino Acid Biosynthetic Process Catalytic Activity RNA Binding Purine Nucleotide Metabolic Process Proteinogenic Amino Acid Catabolic Process L-amino Acid Catabolic Process L-cysteine Transaminase Activity Phosphatidylserine Decarboxylase Activity Nucleotide Metabolic Process Amino Acid Catabolic Process Response To Transition Metal Nanoparticle L-malate Dehydrogenase (NAD+) Activity Malate Dehydrogenase Activity Symbiont-mediated Disruption Of Host Cell PML Body Small Molecule Biosynthetic Process Carbohydrate Biosynthetic Process Glucose Metabolic Process Purine-containing Compound Metabolic Process Trans-4-hydroxy-L-proline Catabolic Process Kynurenine-oxoglutarate Transaminase Activity Phagolysosome Assembly Stereocilium Base Chondrocyte Development Involved In Endochondral Bone Morphogenesis Glycerol Biosynthetic Process Equilibrioception Postsynapse To Nucleus Signaling Pathway	Gamma-tubulin Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Carbon Catabolite Regulation Of Transcription Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Response To Insulin Regulation Of Transcription By Glucose Internal Protein Amino Acid Acetylation Peptidyl-lysine Acetylation Negative Regulation Of Cellular Component Organization Cellular Response To Insulin Stimulus Regulation Of Cellular Response To Stress Chromatin Organization Regulation Of Cellular Component Organization Regulation Of Organelle Organization Histone Acetyltransferase Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Peptide Hormone Histone Acetyltransferase Activity Cellular Response To Low-density Lipoprotein Particle Stimulus Positive Regulation Of Lipid Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Metabolic Process Response To Nutrient Protein Acetylation Replication Fork Processing BRCA2-MAGE-D1 Complex Positive Regulation Of RNA Metabolic Process Cellular Response To Lipoprotein Particle Stimulus Host-mediated Activation Of Viral Process Pyruvate Carboxylase Activity Positive Regulation Of Fatty Acid Metabolic Process Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Catabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Cellular Response To Nutrient Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Negative Regulation Of Macroautophagy Collagen Type XXVI Trimer Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Peptide Hormone Stimulus Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
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