SERPINH1 and KLF13

Number of citations of the paper that reports this interaction (PubMedID 11748222)
52

Data Source:
HPRD (in vivo, in vitro)

		SERPINH1	KLF13
Description		serpin family H member 1	KLF transcription factor 13
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Extracellular Matrix Membrane Raft	Chromatin Nucleus
	Molecular Function	RNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Collagen Binding Unfolded Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Chondrocyte Development Involved In Endochondral Bone Morphogenesis Response To Unfolded Protein Collagen Fibril Organization Collagen Biosynthetic Process Protein Maturation	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Collagen biosynthesis and modifying enzymes
Drugs
Diseases
GWAS		A body shape index ( 34021172) Coronary artery disease ( 33020668 29212778) Height ( 22021425 33713608 31562340 28552196 28270201 25429064 25282103 20881960) Hip circumference adjusted for BMI ( 25673412 34021172) Myocardial infarction ( 33532862) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 34021172)	Appendicular lean mass ( 33097823) Brain volume in infants (intracranial brain volume) ( 28763065) Deep white matter hyperintensities ( 32517579) Eosinophilic esophagitis ( 25017104) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 29403010 32888494) Psoriasis ( 28537254) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32203549) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412)
Interacting Genes		21 interacting genes: BAG6 BRCA2 C1QL3 CD9 CDK9 CEP70 COL26A1 ESR2 FEZ1 H1-5 KAT2B KLF13 LINC01554 NSG2 OGT PC PPARG SLC2A4 SLC35F6 UBQLN4 UBTF	10 interacting genes: CREBBP EP300 HMGN1 KAT2B PCBD1 PRP4K SERPINH1 SIN3A SREBF1 SREBF2
Entrez ID		871	51621
HPRD ID		02968	05620
Ensembl ID		ENSG00000149257	ENSG00000169926
Uniprot IDs		A8K259 P50454	Q9Y2Y9 X5DNR2
PDB IDs
Enriched GO Terms of Interacting Partners?		Gamma-tubulin Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Carbon Catabolite Regulation Of Transcription Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Response To Insulin Regulation Of Transcription By Glucose Internal Protein Amino Acid Acetylation Peptidyl-lysine Acetylation Negative Regulation Of Cellular Component Organization Cellular Response To Insulin Stimulus Regulation Of Cellular Response To Stress Chromatin Organization Regulation Of Cellular Component Organization Regulation Of Organelle Organization Histone Acetyltransferase Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Peptide Hormone Histone Acetyltransferase Activity Cellular Response To Low-density Lipoprotein Particle Stimulus Positive Regulation Of Lipid Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Metabolic Process Response To Nutrient Protein Acetylation Replication Fork Processing BRCA2-MAGE-D1 Complex Positive Regulation Of RNA Metabolic Process Cellular Response To Lipoprotein Particle Stimulus Host-mediated Activation Of Viral Process Pyruvate Carboxylase Activity Positive Regulation Of Fatty Acid Metabolic Process Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Catabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Cellular Response To Nutrient Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Negative Regulation Of Macroautophagy Collagen Type XXVI Trimer Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Peptide Hormone Stimulus Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	N-terminal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation N-terminal Protein Amino Acid Acetylation Chromatin Binding Acetyltransferase Activity Rhythmic Process Cellular Response To Nutrient Levels Histone Acetyltransferase Complex Histone H3K27 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity Chromatin Histone Acetyltransferase Activity Protein Acetylation Histone H3K18 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Response To Nutrient Levels Regulation Of Protein Localization L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Cellular Response To Stress Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation SREBP Signaling Pathway Cellular Response To Sterol Depletion Positive Regulation Of RNA Metabolic Process Nucleoplasm Internal Protein Amino Acid Acetylation Transcription Coactivator Activity Response To Sterol Depletion Protein Maturation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Small Molecule Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Response To Heat Response To Stress Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Transcription Coregulator Activity Chromatin Organization Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Acyltransferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process
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