PARD6A and PRKCH

Number of citations of the paper that reports this interaction (PubMedID 17335965)
0

Data Source:
HPRD (in vivo)

		PARD6A	PRKCH
Description		par-6 family cell polarity regulator alpha	protein kinase C eta
Image
GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Cell Cortex Membrane Apical Plasma Membrane Centriolar Satellite Cell Projection Tight Junction Anchoring Junction PAR Polarity Complex	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extracellular Exosome
	Molecular Function	Protein Binding GTP-dependent Protein Binding Small GTPase Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Enzyme Binding Protein Serine/threonine Kinase Inhibitor Activity Small GTPase Binding Translation Regulator Activity Metal Ion Binding Protein Serine Kinase Activity Protein Serine/threonine Kinase Binding
	Biological Process	Centrosome Cycle Establishment Or Maintenance Of Cell Polarity Viral Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell-cell Junction Maintenance Positive Regulation Of Protein Secretion Cell Division Regulation Of Cellular Localization Positive Regulation Of Protein Localization To Centrosome	Regulation Of Translation Protein Phosphorylation Signal Transduction Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Translation Cell Differentiation Positive Regulation Of Translation In Response To Stress Cellular Response To Amino Acid Starvation Negative Regulation Of Glial Cell Apoptotic Process Intracellular Signal Transduction Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Glial Cell Proliferation Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Bicellular Tight Junction Assembly
Pathways		TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions Asymmetric localization of PCP proteins CDC42 GTPase cycle RAC1 GTPase cycle RHOU GTPase cycle RHOV GTPase cycle	Effects of PIP2 hydrolysis G alpha (z) signalling events
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Asthma ( 32296059) Height ( 28552196) Obesity (early onset extreme) ( 23563609) Reading and spelling ( 23738518) Rheumatoid arthritis ( 22446963 24390342 30423114) Word reading ( 23738518) Yeast infection ( 28928442)
Interacting Genes		28 interacting genes: APP ATP5MG CDC42 CDH5 CRB3 DVL2 ECT2 GLS MAP2K5 MARK2 MARK4 PARD3 PARD6B PLCB1 PLCB3 PRKCG PRKCH PRKCI PRKCZ PTPN21 RAC1 RHOQ SNCA TCP10L3 TGFBR1 WDR83 YWHAH YWHAZ	17 interacting genes: BANP BMP4 C14orf39 CDK2 FYN GSK3A ITGB2 NUMB PARD6A PPP1R14A PRKD1 PTPN11 SIX6 SRC ZBTB8OS ZFP36L1 ZFYVE1
Entrez ID		50855	5583
HPRD ID		06316	05669
Ensembl ID		ENSG00000102981	ENSG00000027075
Uniprot IDs		Q9NPB6	P24723
PDB IDs		1WMH	2FK9 3TXO 8FP1 8FP3
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Intracellular Signal Transduction Regulation Of Cellular Component Organization Bicellular Tight Junction PAR Polarity Complex Positive Regulation Of Cellular Component Organization Establishment Of Cell Polarity Cell-cell Junction Organization Diacylglycerol-dependent Serine/threonine Kinase Activity Cell Junction Organization Cell-cell Junction Regulation Of Cell Projection Organization Phosphate-containing Compound Metabolic Process Positive Regulation Of Cell Projection Organization Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Protein Serine/threonine Kinase Activity Apical Part Of Cell Signal Transduction Positive Regulation Of Protein Localization Cell Cortex Tight Junction Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Synaptic Plasticity Regulation Of Protein Localization Protein Kinase Activity Regulation Of Developmental Process Protein Phosphorylation Positive Regulation Of Cellular Component Biogenesis Protein Serine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Programmed Cell Death Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Phosphorylation GBD Domain Binding Regulation Of Cell Communication Regulation Of Signaling Anchoring Junction Kinase Activity Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cytoplasm Supramolecular Fiber Organization Modulation Of Chemical Synaptic Transmission Positive Regulation Of Filopodium Assembly Postsynaptic Cytosol	Regulation Of Cellular Localization Regulation Of Protein Localization Cellular Response To Growth Factor Stimulus Regulation Of Establishment Of Protein Localization Response To Growth Factor Forebrain Development Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Protein Localization To Nucleus Integrin-mediated Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Transport Positive Regulation Of Multicellular Organismal Process Response To Peptide Hormone Positive Regulation Of Establishment Of Protein Localization T Cell Costimulation Regulation Of Protein Localization To Nucleus Cellular Response To Hormone Stimulus Ephrin Receptor Signaling Pathway Negative Regulation Of Neutrophil Activation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Multicellular Organismal Development Regulation Of Leukocyte Cell-cell Adhesion Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Phospholipase Activator Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peptide Hormone Receptor Binding Regulation Of Neutrophil Activation Positive Regulation Of Protein Localization BMP Receptor Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neutrophil Activation Involved In Immune Response Cellular Response To Steroid Hormone Stimulus Regulation Of Cell Adhesion Regulation Of Striated Muscle Cell Differentiation Protein Kinase Activity Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Intracellular Transport Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Response To Chemical Stress Negative Regulation Of Cell Cycle Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Leukocyte Cell-cell Adhesion Cell Differentiation Regulation Of Developmental Process Leukocyte Activation Tau-protein Kinase Activity Stimulatory C-type Lectin Receptor Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?