ARHGEF3 and CEP70

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARHGEF3	CEP70
Description		Rho guanine nucleotide exchange factor 3	centrosomal protein 70
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Centrosome Microtubule Organizing Center Cytosol Cytoskeleton
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding Identical Protein Binding Gamma-tubulin Binding
	Biological Process	Rho Protein Signal Transduction Positive Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction	Cilium Assembly Regulation Of Microtubule Cytoskeleton Organization
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Asthma ( 32296059) Attention function in attention deficit hyperactive disorder ( 26174813) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Glaucoma (primary open-angle) ( 33627673) Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Idiopathic dilated cardiomyopathy ( 29495422) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean arterial pressure ( 27618448) Mean platelet volume ( 19110211 19820697 32888494 22139419 24026423 31194788 27863252 28031487) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Multiple sclerosis ( 31604244) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Obesity-related traits ( 23251661) Platelet count ( 22139419 32888494 27863252 29066854 23263863 28031487 26805783 29403010 24026423) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Refractive error ( 32231278) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Rheumatoid arthritis ( 21452313) Systolic blood pressure ( 30578418)	Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Femur bone mineral density x serum urate levels interaction ( 34046847) Male-pattern baldness ( 28196072)
Interacting Genes		9 interacting genes: CEP70 HSF2BP PBX4 PICK1 RHOA RHOB TERF1 TRIM23 TRIM27	245 interacting genes: ABT1 AGBL2 AKAP17A ARHGEF3 ARMCX1 ATOSB ATP5PO ATXN7 BARD1 BAZ2B BEX2 BRD1 BRMS1 BRMS1L BRPF1 BYSL C1orf35 C7orf25 C8orf33 CARD9 CAVIN3 CBX8 CCDC187 CCDC85B CDC37 CDC73 CDCA7L CEP57L1 CFAP53 CLPB COIL CWF19L2 DAXX DAZAP2 DDX41 DDX6 DNAJB11 DNTTIP2 DRC4 DVL3 DYRK1A EAF1 EBNA1BP2 EIF3D ELOA ELOA2 EMD EMP1 ENKD1 ERCC3 FAM118B FAM124A FAM133A FAM13C FAM161A FAM161B FAM90A1 GADD45GIP1 GATAD2B GCC1 GEM GLYCTK GPATCH2L GPATCH4 GPX7 GSE1 HAUS1 HDAC4 HDAC6 HIC2 HMGB4 HOXB5 HOXC8 HSPD1 IK INO80B INPP5J IPCEF1 IQCE IQUB ITPKB KANK2 KANSL1 KAT14 KAT5 KAT7 KDM1A KRI1 KRT31 LAMTOR5 LCOR LENG1 LENG8 LIN37 LNX1 MAB21L2 MAGOH MBD3 MCM10 MCRS1 MEST METTL17 MFAP1 MKRN3 MRPL44 NEBL NIPSNAP3A NKAP NKAPD1 NOL12 NOP2 NOP53 NOXA1 NRIP1 NTAQ1 NUSAP1 ODAD4 PAM16 PIBF1 PIMREG PKN1 PLA2G2A PPFIA1 PPIG PPP1R16B PPP1R18 PRKRIP1 PRPF18 PRPF3 PRPF31 PSMA1 PSORS1C2 RASSF10 RBM10 RCOR3 RHPN1 RNF169 RNF6 RPL13 SCNM1 SEC14L1 SERPINH1 SETD5 SFR1 SH2D4A SLU7 SMARCE1 SNRPD2 SNW1 SOD2 SPANXN3 SRGN SSX3 STK25 STMN2 SUV39H1 SUV39H2 SYT17 SYTL4 SYTL5 TAF1D TBC1D22B TBC1D30 TCAF1 TCEA2 TCEANC TEAD4 TLK2 TRAF3IP3 TRIM29 TRIM3 TRIM42 TSFM TSGA10IP TSHZ3 TTLL10 TXLNB TXN2 USP2 UTP11 UTP14A UTP14C UTP25 UTP3 VXN WT1 YJU2 ZBTB16 ZBTB24 ZBTB4 ZBTB47 ZBTB48 ZBTB49 ZBTB8A ZCCHC10 ZFC3H1 ZFHX3 ZFP1 ZFP91 ZGPAT ZNF136 ZNF140 ZNF148 ZNF165 ZNF169 ZNF17 ZNF20 ZNF202 ZNF227 ZNF239 ZNF250 ZNF264 ZNF266 ZNF302 ZNF329 ZNF35 ZNF366 ZNF408 ZNF410 ZNF417 ZNF426 ZNF433 ZNF439 ZNF490 ZNF491 ZNF555 ZNF557 ZNF572 ZNF574 ZNF578 ZNF587 ZNF599 ZNF607 ZNF648 ZNF669 ZNF688 ZNF696 ZNF775 ZNF777 ZNF785 ZNF835 ZNF860 ZSCAN12 ZSCAN21 ZSCAN23
Entrez ID		50650	80321
HPRD ID		12480	16779
Ensembl ID		ENSG00000163947	ENSG00000114107
Uniprot IDs		B7Z6B2 B7Z7T8 C9J586 E9PG37 Q9NR81	A0A140VJG2 B7Z2D2 Q8NHQ1
PDB IDs
Enriched GO Terms of Interacting Partners?		Endothelial Tube Morphogenesis Regulation Of Modification Of Postsynaptic Structure Regulation Of Modification Of Synaptic Structure Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Actin Nucleation GTPase Activity Regulation Of Cellular Component Organization Rho Protein Signal Transduction Actin Filament Organization Mitotic Cytokinesis Regulation Of Actin Filament Organization Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Cleavage Furrow Mitotic Cleavage Furrow Formation Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Identical Protein Binding GTP Binding GDP Binding Aortic Valve Formation Regulation Of Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Cytoskeleton-dependent Cytokinesis Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Regulation Of Actin Filament-based Process Skeletal Muscle Satellite Cell Migration Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Epithelial Tube Morphogenesis Beta Selection Supramolecular Fiber Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Bone Trabecula Morphogenesis Membrane Curvature Sensor Activity Intracellular Transport Intracellular Protein Transport Apolipoprotein A-I-mediated Signaling Pathway Roundabout Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Regulation Of Systemic Arterial Blood Pressure By Endothelin Forebrain Radial Glial Cell Differentiation Fibrillar Center Regulation Of Establishment Of Protein Localization To Telomere Shelterin Complex Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Zinc Ion Binding Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Nucleus Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA Binding Regulation Of Primary Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Metal Ion Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleolus RNA Processing Nuclear Speck Spliceosomal Complex Nucleoplasm RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Histone Acetyltransferase Complex Chromatin Organization Nuclear Androgen Receptor Binding Protein-RNA Complex Assembly Negative Regulation Of Macromolecule Biosynthetic Process Chromosome Transcription Elongation By RNA Polymerase II RRNA Processing RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Remodeling Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process RNA Binding DNA-templated Transcription Elongation RNA Metabolic Process Histone H3-K14 Acetyltransferase Complex MRNA Processing Ribonucleoprotein Complex Biogenesis RRNA Metabolic Process Nucleic Acid Metabolic Process
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