ARHGEF3

Description		Rho guanine nucleotide exchange factor 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Rho Protein Signal Transduction Positive Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle
Drugs
Diseases
GWAS		Asthma ( 32296059) Attention function in attention deficit hyperactive disorder ( 26174813) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Glaucoma (primary open-angle) ( 33627673) Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Idiopathic dilated cardiomyopathy ( 29495422) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean arterial pressure ( 27618448) Mean platelet volume ( 19110211 19820697 32888494 22139419 24026423 31194788 27863252 28031487) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Multiple sclerosis ( 31604244) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Obesity-related traits ( 23251661) Platelet count ( 22139419 32888494 27863252 29066854 23263863 28031487 26805783 29403010 24026423) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Refractive error ( 32231278) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Rheumatoid arthritis ( 21452313) Systolic blood pressure ( 30578418)
Novel Interacting Genes		9 novel interacting genes: CEP70 HSF2BP PBX4 PICK1 RHOA RHOB TERF1 TRIM23 TRIM27
Interacting Genes		9 interacting genes: CEP70 HSF2BP PBX4 PICK1 RHOA RHOB TERF1 TRIM23 TRIM27
Entrez ID		50650
HPRD ID		12480
Ensembl ID		ENSG00000163947
Uniprot IDs		B7Z6B2 B7Z7T8 C9J586 E9PG37 Q9NR81
PDB IDs
Enriched GO Terms of Interacting Partners?		Endothelial Tube Morphogenesis Regulation Of Modification Of Postsynaptic Structure Regulation Of Modification Of Synaptic Structure Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Actin Nucleation GTPase Activity Regulation Of Cellular Component Organization Rho Protein Signal Transduction Actin Filament Organization Mitotic Cytokinesis Regulation Of Actin Filament Organization Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Cleavage Furrow Mitotic Cleavage Furrow Formation Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Identical Protein Binding GTP Binding GDP Binding Aortic Valve Formation Regulation Of Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Cytoskeleton-dependent Cytokinesis Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Regulation Of Actin Filament-based Process Skeletal Muscle Satellite Cell Migration Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Epithelial Tube Morphogenesis Beta Selection Supramolecular Fiber Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Bone Trabecula Morphogenesis Membrane Curvature Sensor Activity Intracellular Transport Intracellular Protein Transport Apolipoprotein A-I-mediated Signaling Pathway Roundabout Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Regulation Of Systemic Arterial Blood Pressure By Endothelin Forebrain Radial Glial Cell Differentiation Fibrillar Center Regulation Of Establishment Of Protein Localization To Telomere Shelterin Complex Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation
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