P2RX7 and EMP3

Number of citations of the paper that reports this interaction (PubMedID 12107182)
0

Data Source:
HPRD (in vitro)

		P2RX7	EMP3
Description		purinergic receptor P2X 7	epithelial membrane protein 3 (MAM blood group)
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Membrane Neuromuscular Junction Bleb Neuronal Cell Body Synapse Presynapse Postsynapse	Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Lipopolysaccharide Binding Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Monoatomic Cation Channel Activity Signaling Receptor Binding Monoatomic Ion Channel Activity Potassium Channel Activity Sodium Channel Activity Protein Binding ATP Binding GTP Binding Channel Activity Signaling Receptor Activity Identical Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	MAPK Cascade Cell Morphogenesis Phagolysosome Assembly T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Sodium Ion Transport Response To Ischemia Membrane Protein Ectodomain Proteolysis Phospholipid Transfer To Membrane Monoatomic Ion Transport Monoatomic Cation Transport Calcium Ion Transport Cell Volume Homeostasis Vesicle Budding From Membrane Inflammatory Response Mitochondrion Organization Plasma Membrane Organization Cell Surface Receptor Signaling Pathway Protein Secretion Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Bacterium Response To Zinc Ion Gene Expression Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Gene Expression Programmed Cell Death Glutamate Secretion Positive Regulation Of Glutamate Secretion Gamma-aminobutyric Acid Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Organophosphate Ester Transport Synaptic Vesicle Exocytosis Protein Processing Plasma Membrane Phospholipid Scrambling Sensory Perception Of Pain Calcium-mediated Signaling Protein Catabolic Process Positive Regulation Of Bone Mineralization Bleb Assembly Positive Regulation Of Prostaglandin Secretion Prostaglandin Secretion Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Collagen Metabolic Process Response To ATP Monoatomic Ion Transmembrane Transport Response To Fluid Shear Stress Positive Regulation Of Monoatomic Ion Transmembrane Transport Purinergic Nucleotide Receptor Signaling Pathway Sodium Ion Transmembrane Transport T Cell Proliferation T Cell Homeostasis Positive Regulation Of Apoptotic Process NAD Transport Negative Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Phospholipid Translocation Positive Regulation Of Ossification Negative Regulation Of Bone Resorption Negative Regulation Of Cell Volume Positive Regulation Of Glycolytic Process Ceramide Biosynthetic Process Pore Complex Assembly Skeletal System Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Protein Secretion Defense Response To Gram-positive Bacterium Regulation Of Transport Positive Regulation Of Cellular Component Organization Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytoskeleton Organization Response To Calcium Ion Response To Electrical Stimulus Establishment Of Localization In Cell Mitochondrial Depolarization Membrane Depolarization Positive Regulation Of Mitochondrial Depolarization Excitatory Postsynaptic Potential Positive Regulation Of Macrophage Cytokine Production Protein Homotrimerization Lymphocyte Apoptotic Process Positive Regulation Of Lymphocyte Apoptotic Process T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process Calcium Ion Transmembrane Transport Cellular Response To ATP Cellular Response To DsRNA Potassium Ion Transmembrane Transport Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Monoatomic Cation Transmembrane Transport Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Bleb Assembly	Apoptotic Process Bleb Assembly
Pathways		Elevation of cytosolic Ca2+ levels Platelet homeostasis The NLRP3 inflammasome The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Drugs		Promethazine
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Birth weight ( 31043758) Chronic obstructive pulmonary disease-related biomarkers ( 23144326)
Interacting Genes		20 interacting genes: ACTB CASK CSF2 CYSRT1 EFEMP2 EFNB3 EMP3 HSF2BP KRT31 KRT34 KRTAP10-8 NBPF19 NOTCH2NLA PANX1 PLEKHF2 PTPN11 SVIL TM9SF1 TRIM27 ZNF655	43 interacting genes: AQP6 CD79A CLDN2 CLDN7 CREB3L1 CREM EDA ELOVL7 ERGIC3 FAM210B FNDC9 GJA5 GJB1 GPA33 GPR61 IFNGR2 IL3RA KIR3DL3 KLRC1 LDLRAD1 LEUTX LHFPL5 LRRC4C LYVE1 MR1 MS4A3 MUC1 OPRM1 P2RX7 PLEKHB2 RMDN3 SAR1A SECTM1 SIGLECL1 SLAMF8 SLC30A2 SLC35H1 SMIM3 SPACA1 TM4SF18 TMX2 TSPAN12 VSIG1
Entrez ID		5027	2014
HPRD ID		03977	18514
Ensembl ID		ENSG00000089041	ENSG00000142227
Uniprot IDs		Q99572	P54852
PDB IDs
Enriched GO Terms of Interacting Partners?			Membrane Protein Binding Plasma Membrane Gap Junction Assembly Regulation Of T Cell Mediated Immunity Regulation Of T Cell Mediated Cytotoxicity Cell-cell Junction Assembly
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