ORC4 and FBXO6

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ORC4	FBXO6
Description		origin recognition complex subunit 4	F-box protein 6
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Nucleolus Cytoplasm Cytosol	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Nucleotide Binding DNA Binding DNA Replication Origin Binding Protein Binding ATP Binding	Protein Binding Carbohydrate Binding Ubiquitin Protein Ligase Activity
	Biological Process	DNA Replication DNA Replication Initiation Polar Body Extrusion After Meiotic Divisions Protein Polymerization	DNA Damage Checkpoint Signaling DNA Repair Proteolysis Ubiquitin-dependent Protein Catabolic Process Glycoprotein Catabolic Process DNA Damage Response Response To Unfolded Protein Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process ERAD Pathway
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS		Estimated glomerular filtration rate ( 30604766 31015462 31152163) Loneliness (MTAG) ( 29970889) Serum uric acid levels ( 30993211) Urate levels ( 31578528)	Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701)
Interacting Genes		28 interacting genes: APP CCND1 CDKN2A CTBP1 FBXL5 FBXL8 FBXO25 FBXO6 H3-4 H4C16 KLHL20 KPNA1 MCM10 MCM2 MCM3 MCM4 MCM6 MCM7 MLH1 MTUS1 ORC1 ORC2 ORC3 ORC5 ORC6 RDH5 RRM2B TCF4	3 interacting genes: ORC4 RIOK1 SKP1
Entrez ID		5000	26270
HPRD ID		09118	07291
Ensembl ID		ENSG00000115947	ENSG00000116663
Uniprot IDs		A8K7H4 O43929 Q96B14	Q9NRD1
PDB IDs		5UJ7 5UJM 7CTE 7CTF 7CTG 7JPO 7JPP 7JPQ 7JPR 7JPS 8RWV 8S0C 8S0D 8S0E 8S0F
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation DNA Replication Nuclear Origin Of Replication Recognition Complex Chromosome, Telomeric Region Origin Recognition Complex DNA Replication Origin Binding DNA Metabolic Process CMG Complex MCM Complex Double-strand Break Repair Via Break-induced Replication Regulation Of DNA-templated DNA Replication Initiation Single-stranded DNA Binding Regulation Of DNA Replication Nucleus Mitotic DNA Replication Initiation Single-stranded DNA Helicase Activity Regulation Of DNA Metabolic Process Chromosome Nucleic Acid Metabolic Process DNA Damage Response DNA Helicase Activity Nucleoplasm DNA Repair DNA Binding Double-strand Break Repair DNA Strand Elongation Involved In DNA Replication ATP Hydrolysis Activity Nucleobase-containing Compound Metabolic Process Helicase Activity DNA Recombination Double-strand Break Repair Via Homologous Recombination Macromolecule Metabolic Process Recombinational Repair DNA Strand Elongation Cellular Response To Stress DNA-templated DNA Replication SCF Ubiquitin Ligase Complex Regulation Of Nucleobase-containing Compound Metabolic Process Protein-DNA Complex Assembly Mammary Gland Epithelial Cell Proliferation Regulation Of Mammary Gland Epithelial Cell Proliferation Enzyme Binding Nucleolus Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle Nucleosome Assembly Cell Population Proliferation Regulation Of Cell Cycle G2/M Phase Transition Amyloid Fibril Formation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle	Nuclear Origin Of Replication Recognition Complex Meiotic Cytokinesis Origin Recognition Complex Polar Body Extrusion After Meiotic Divisions F-box Domain Binding Cul7-RING Ubiquitin Ligase Complex Ubiquitin Ligase Complex Scaffold Activity Positive Regulation Of RRNA Processing Methyltransferase Complex Ubiquitin Ligase Activator Activity Preribosome, Small Subunit Precursor Regulation Of RRNA Processing DNA Replication Origin Binding DNA Replication Initiation Maintenance Of Protein Location In Nucleus PcG Protein Complex Cullin Family Protein Binding Molecular Function Activator Activity Positive Regulation Of Epithelial Cell Apoptotic Process Maturation Of SSU-rRNA Maintenance Of Protein Localization In Organelle
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