WRAP73 and TNFRSF8

		WRAP73	TNFRSF8
Description		WD repeat containing, antisense to TP73	TNF receptor superfamily member 8
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytoskeleton Centriolar Satellite Ciliary Basal Body MWP Complex	Nucleoplasm Cytoplasm Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Protease Binding Transmembrane Signaling Receptor Activity
	Biological Process	Cell Projection Organization Mitotic Spindle Assembly Positive Regulation Of Non-motile Cilium Assembly	Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of TRAIL Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus
Pathways			TNFs bind their physiological receptors
Drugs			Iratumumab XmAb 2513 Brentuximab vedotin
Diseases
GWAS			Asthma ( 31959851 32296059 34103634) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Serum alkaline phosphatase levels ( 33339817) Sum eosinophil basophil counts ( 27863252) Tuberculosis ( 29036319)
Interacting Genes		2 interacting genes: TNFRSF18 TNFRSF8	14 interacting genes: ALK CLCN6 EPHA2 HPCA PRDX4 RUNX3 SH3BGRL3 TDP2 TNFSF8 TRAF1 TRAF2 TRAF3 TRAF5 WRAP73
Entrez ID		49856	943
HPRD ID		06918	01074
Ensembl ID		ENSG00000116213	ENSG00000120949
Uniprot IDs		A0A384MQZ3 Q9P2S5	A5D8T4 P28908
PDB IDs			1D01
Enriched GO Terms of Interacting Partners?		Positive Regulation Of TRAIL Production Regulation Of TRAIL Production Tumor Necrosis Factor Receptor Activity	Tumor Necrosis Factor Receptor Binding Thioesterase Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Positive Regulation Of DNA-binding Transcription Factor Activity CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Ubiquitin Protein Ligase Binding Cytoplasmic Side Of Plasma Membrane Regulation Of Canonical NF-kappaB Signal Transduction Identical Protein Binding Cytokine-mediated Signaling Pathway Signal Transduction Neuron Development Signal Transduction Involved In Regulation Of Gene Expression Cell Surface Receptor Signaling Pathway Receptor Complex Apoptotic Process Response To Environmental Enrichment Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Death Notochord Cell Development Programmed Cell Death TORC2 Complex Disassembly MWP Complex 5'-tyrosyl-DNA Phosphodiesterase Activity Tyrosyl-RNA Phosphodiesterase Activity Tyrosyl-DNA Phosphodiesterase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process MRNA Stabilization Swimming Behavior Axial Mesoderm Formation Response To Ketamine TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of RNA Metabolic Process Receptor Signaling Protein Tyrosine Kinase Activator Activity Core-binding Factor Complex Negative Regulation Of Lymphangiogenesis Notochord Formation I-kappaB Phosphorylation Negative Regulation Of Male Germ Cell Proliferation Protein Phosphorylation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?