TNFRSF8 and SH3BGRL3

		TNFRSF8	SH3BGRL3
Description		TNF receptor superfamily member 8	SH3 domain binding glutamate rich protein like 3
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Membrane Extracellular Exosome	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Body Ruffle Membrane Cell Projection Extracellular Exosome
	Molecular Function	Protease Binding Transmembrane Signaling Receptor Activity	Glutathione Transferase Activity Protein Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of TRAIL Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus	Cytoskeleton Organization
Pathways		TNFs bind their physiological receptors
Drugs		Iratumumab XmAb 2513 Brentuximab vedotin
Diseases
GWAS		Asthma ( 31959851 32296059 34103634) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Serum alkaline phosphatase levels ( 33339817) Sum eosinophil basophil counts ( 27863252) Tuberculosis ( 29036319)
Interacting Genes		14 interacting genes: ALK CLCN6 EPHA2 HPCA PRDX4 RUNX3 SH3BGRL3 TDP2 TNFSF8 TRAF1 TRAF2 TRAF3 TRAF5 WRAP73	6 interacting genes: APP CDC42 DDIT4L EGFR ERBB2 TNFRSF8
Entrez ID		943	83442
HPRD ID		01074	15332
Ensembl ID		ENSG00000120949	ENSG00000142669
Uniprot IDs		A5D8T4 P28908	Q9H299
PDB IDs		1D01	1SJ6
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Thioesterase Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Positive Regulation Of DNA-binding Transcription Factor Activity CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Ubiquitin Protein Ligase Binding Cytoplasmic Side Of Plasma Membrane Regulation Of Canonical NF-kappaB Signal Transduction Identical Protein Binding Cytokine-mediated Signaling Pathway Signal Transduction Neuron Development Signal Transduction Involved In Regulation Of Gene Expression Cell Surface Receptor Signaling Pathway Receptor Complex Apoptotic Process Response To Environmental Enrichment Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Death Notochord Cell Development Programmed Cell Death TORC2 Complex Disassembly MWP Complex 5'-tyrosyl-DNA Phosphodiesterase Activity Tyrosyl-RNA Phosphodiesterase Activity Tyrosyl-DNA Phosphodiesterase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process MRNA Stabilization Swimming Behavior Axial Mesoderm Formation Response To Ketamine TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of RNA Metabolic Process Receptor Signaling Protein Tyrosine Kinase Activator Activity Core-binding Factor Complex Negative Regulation Of Lymphangiogenesis Notochord Formation I-kappaB Phosphorylation Negative Regulation Of Male Germ Cell Proliferation Protein Phosphorylation	ERBB2-EGFR Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of Growth Receptor Complex Regulation Of MAPK Cascade Positive Regulation Of Cell Growth Positive Regulation Of Epithelial Cell Proliferation ERBB2 Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Population Proliferation Transmembrane Signaling Receptor Activity Positive Regulation Of Growth Positive Regulation Of Phosphate Metabolic Process Neuron Projection Organization Regulation Of ERK1 And ERK2 Cascade Intracellular Signaling Cassette Response To Growth Factor Cellular Response To Growth Factor Stimulus Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Cycle Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Glial Cell Development Regulation Of Epithelial Cell Proliferation Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane Regulation Of Cell Growth Positive Regulation Of Intracellular Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of MiRNA Transcription Amylin Binding Positive Regulation Of Toll Signaling Pathway ERBB Signaling Pathway Multivesicular Body, Internal Vesicle Lumen Cell Junction Organization Regulation Of MiRNA Metabolic Process Neuron Projection Development Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Mitotic Cell Cycle Ruffle Membrane Acetylcholine Receptor Activator Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Apoptotic Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Lipoprotein Particle
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