ACR and ZP2

Number of citations of the paper that reports this interaction (PubMedID 11739644)
0

Data Source:
HPRD (in vitro)

		ACR	ZP2
Description		acrosin	zona pellucida glycoprotein 2
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Nucleus Golgi-associated Vesicle Protein-containing Complex Acrosomal Matrix	Extracellular Region Multivesicular Body Endoplasmic Reticulum Plasma Membrane Membrane Extracellular Matrix Egg Coat
	Molecular Function	Protease Binding DNA Binding Amidase Activity Serine-type Endopeptidase Activity Copper Ion Binding Protein Binding D-mannose Binding Peptidase Activity Serine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Fucose Binding	Protein Binding Coreceptor Activity Acrosin Binding Structural Constituent Of Egg Coat Identical Protein Binding
	Biological Process	Acrosome Matrix Dispersal Proteolysis Activation Of Adenylate Cyclase Activity Single Fertilization Binding Of Sperm To Zona Pellucida Acrosome Reaction Penetration Of Zona Pellucida Protein Catabolic Process Response To Steroid Hormone	Single Fertilization Binding Of Sperm To Zona Pellucida Regulation Of Acrosome Reaction Prevention Of Polyspermy
Pathways		Acrosome Reaction and Sperm:Oocyte Membrane Binding	Interaction With Cumulus Cells And The Zona Pellucida
Drugs
Diseases
GWAS			Pelvic organ prolapse ( 26545240)
Interacting Genes		3 interacting genes: SERPINA5 ZP2 ZP3	2 interacting genes: ACR ZPBP
Entrez ID		49	7783
HPRD ID		06342	01689
Ensembl ID		ENSG00000100312	ENSG00000103310
Uniprot IDs		P10323	Q05996
PDB IDs			8RKE 8RKF
Enriched GO Terms of Interacting Partners?		Acrosin Binding Structural Constituent Of Egg Coat Egg Coat Single Fertilization Fertilization Regulation Of Acrosome Reaction Binding Of Sperm To Zona Pellucida Extracellular Matrix Sperm-egg Recognition Cell-cell Recognition Negative Regulation Of Reproductive Process Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Cell Recognition Positive Regulation Of Type IV Hypersensitivity Positive Regulation Of Antral Ovarian Follicle Growth Seminal Clot Liquefaction Regulation Of Reproductive Process Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Egg Coat Formation Reproductive Process Platelet Dense Tubular Network Regulation Of Acrosomal Vesicle Exocytosis Negative Regulation Of Binding Of Sperm To Zona Pellucida Regulation Of Type IV Hypersensitivity Prevention Of Polyspermy Regulation Of Binding Of Sperm To Zona Pellucida Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Ovarian Follicle Development Positive Regulation Of Hypersensitivity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Acrosome Reaction Regulation Of Fertilization Extracellular Region Positive Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Acute Inflammatory Response To Antigenic Stimulus Oocyte Development Positive Regulation Of Calcium Ion-dependent Exocytosis Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Platelet Alpha Granule Plasma Membrane Fusion	Binding Of Sperm To Zona Pellucida Sperm-egg Recognition Cell-cell Recognition Acrosomal Vesicle Cell Recognition Acrosome Matrix Dispersal Amidase Activity Acrosomal Matrix Fucose Binding Zona Pellucida Receptor Complex Penetration Of Zona Pellucida Activation Of Adenylate Cyclase Activity Positive Regulation Of Adenylate Cyclase Activity Acrosome Reaction Golgi-associated Vesicle Positive Regulation Of Lyase Activity Positive Regulation Of Cyclase Activity D-mannose Binding Acrosomal Membrane Acrosome Assembly Copper Ion Binding Reproductive Process Secretory Granule Organization Single Fertilization Protease Binding Serine-type Peptidase Activity Extracellular Region Fertilization Serine-type Endopeptidase Activity
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