NPR2 and NPPA

Number of citations of the paper that reports this interaction (PubMedID 1672777)
0

Data Source:
BioGRID (pull down)

		NPR2	NPPA
Description		natriuretic peptide receptor 2	natriuretic peptide A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Cilium Membrane Neuron Projection Synapse	Extracellular Region Extracellular Space Cytoplasm Brush Border Protein-containing Complex Mast Cell Granule Cell Projection Perikaryon Perinuclear Region Of Cytoplasm Glycinergic Synapse
	Molecular Function	Nucleotide Binding Guanylate Cyclase Activity Protein Kinase Activity Protein Binding ATP Binding GTP Binding Lyase Activity Phosphorus-oxygen Lyase Activity Natriuretic Peptide Receptor Activity Peptide Hormone Binding Hormone Binding Identical Protein Binding	Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Guanylate Cyclase Activator Activity Hormone Receptor Binding Neuropeptide Receptor Binding
	Biological Process	MAPK Cascade Ossification Ovarian Follicle Development Cumulus Cell Differentiation Blood Vessel Development Vasculogenesis Lymph Vessel Development Endochondral Ossification Startle Response Blood Vessel Remodeling Chondrocyte Differentiation Growth Plate Cartilage Development CGMP Biosynthetic Process Vacuole Organization Receptor Guanylyl Cyclase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Chemical Synaptic Transmission Germ Cell Development Spermatogenesis Single Fertilization Axonogenesis Sensory Perception Of Sound Blood Circulation Regulation Of Blood Pressure Cyclic Nucleotide Biosynthetic Process Response To Wounding Response To Hormone Neuronal Action Potential Vestibulocochlear Nerve Development Vestibulocochlear Nerve Maturation Nerve Development Female Genitalia Development Response To Luteinizing Hormone Limb Morphogenesis Genitalia Morphogenesis Multicellular Organism Growth Gastric Emptying Intracellular Signal Transduction Chondrocyte Proliferation Post-anal Tail Morphogenesis CGMP Metabolic Process Digestive Tract Morphogenesis Digestive Tract Development Oocyte Development Collateral Sprouting Smooth Muscle Tissue Development White Fat Cell Differentiation Cartilage Development Chromosome Organization Meiotic Cell Cycle Neuron Apoptotic Process Negative Regulation Of Meiotic Cell Cycle Limb Development Bone Development Axonogenesis Involved In Innervation Activation Of Meiosis Involved In Egg Activation Vascular Wound Healing C-di-GMP Signaling Cellular Response To CGMP Response To Fibroblast Growth Factor Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Execution Phase Of Apoptosis Bone Growth Negative Regulation Of Oocyte Maturation Cellular Response To Peptide Response To Salt Meiotic Cell Cycle Process Involved In Oocyte Maturation	Response To Hypoxia System Process Negative Regulation Of Systemic Arterial Blood Pressure Cardiac Conduction System Development Aortic Valve Morphogenesis CGMP Biosynthetic Process Protein Folding Receptor Guanylyl Cyclase Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Regulation Of Blood Pressure Positive Regulation Of Heart Rate Positive Regulation Of CGMP-mediated Signaling Cardiac Muscle Hypertrophy In Response To Stress CGMP-mediated Signaling Negative Regulation Of Cell Growth Response To Insulin Response To Muscle Stretch Sodium Ion Export Across Plasma Membrane Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vasodilation Regulation Of Vascular Permeability Negative Regulation Of JUN Kinase Activity Negative Regulation Of Blood Pressure Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Cardiac Muscle Contraction Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Hydrogen Peroxide Cellular Response To Mechanical Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Blood Vessel Diameter Maintenance Synaptic Signaling Via Neuropeptide Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Positive Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Collecting Lymphatic Vessel Constriction Cellular Response To Angiotensin Response To 3-methylcholanthrene
Pathways		Physiological factors	YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Amyloid fiber formation
Drugs		Erythrityl tetranitrate Nesiritide Vosoritide
Diseases		Acromesomelic dysplasia, Maroteaux type	Atrial fibrillation
GWAS		Brain morphology (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Height ( 31562340)	Atrial fibrillation ( 19597492) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Midregional pro atrial natriuretic peptide levels ( 29237677) Psoriasis ( 25854761) Pulse pressure ( 30578418) Systolic blood pressure ( 19430483 30578418) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tuberculosis ( 29036319)
Interacting Genes		4 interacting genes: DNAI1 NPPA NPPB NPPC	15 interacting genes: EPB41 ESR1 HNF4A HSF2BP KAZN MAGEA12 MME NPR1 NPR2 NPR3 NR5A2 RORB UBQLN1 UBQLN2 UBQLN4
Entrez ID		4882	4878
HPRD ID		00166	00164
Ensembl ID		ENSG00000159899	ENSG00000175206
Uniprot IDs		P20594	P01160
PDB IDs			1ANP 1YK0 3N57 7BRH 7BRJ 7BRK 8TG9 9BCQ
Enriched GO Terms of Interacting Partners?		Hormone Receptor Binding Guanylate Cyclase Activator Activity Receptor Guanylyl Cyclase Signaling Pathway CGMP Biosynthetic Process CGMP Metabolic Process Cyclic Nucleotide Biosynthetic Process CGMP-mediated Signaling Cyclic Purine Nucleotide Metabolic Process Positive Regulation Of CGMP-mediated Signaling Hormone Activity Purine Ribonucleotide Biosynthetic Process Enzyme-linked Receptor Protein Signaling Pathway Blood Vessel Diameter Maintenance Ribose Phosphate Biosynthetic Process Regulation Of Tube Size Regulation Of CGMP-mediated Signaling Purine Nucleotide Biosynthetic Process Cardiac Conduction System Development Nucleotide Biosynthetic Process Protein Folding Purine-containing Compound Biosynthetic Process Negative Regulation Of Systemic Arterial Blood Pressure Vascular Process In Circulatory System Nucleoside Phosphate Biosynthetic Process Purine Ribonucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Circulatory System Process Purine Nucleotide Metabolic Process Regulation Of Vascular Permeability Negative Regulation Of Blood Pressure Signaling Receptor Binding Nucleotide Metabolic Process Vasodilation Carbohydrate Derivative Biosynthetic Process Cardiac Muscle Tissue Development Purine-containing Compound Metabolic Process Organophosphate Biosynthetic Process Nucleoside Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Regulation Of Growth Cell Surface Receptor Signaling Pathway Neuropeptide Signaling Pathway Negative Regulation Of Collecting Lymphatic Vessel Constriction Extracellular Region Diuretic Hormone Activity Protein-containing Complex Striated Muscle Tissue Development Carbohydrate Derivative Metabolic Process Neuropeptide Receptor Binding	Natriuretic Peptide Receptor Activity Nuclear Receptor Activity CGMP Biosynthetic Process Hormone Binding CGMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Peptide Hormone Binding Polyubiquitin Modification-dependent Protein Binding Cyclic Purine Nucleotide Metabolic Process Guanylate Cyclase Activity Intracellular Receptor Signaling Pathway Positive Regulation Of Urine Volume Receptor Guanylyl Cyclase Signaling Pathway Autophagosome Rhythmic Process Nucleobase-containing Compound Biosynthetic Process Female Genitalia Development Positive Regulation Of ERAD Pathway Phosphorus-oxygen Lyase Activity Regulation Of Urine Volume Purine Ribonucleotide Biosynthetic Process Regulation Of ERAD Pathway Peptide Binding Ribose Phosphate Biosynthetic Process Protein-containing Complex Ovulation Cycle Process Sequence-specific DNA Binding Transcription Coregulator Binding Genitalia Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Blood Pressure Purine Nucleotide Biosynthetic Process Blood Circulation G Protein-coupled Peptide Receptor Activity Vacuole Organization Blood Vessel Remodeling Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Macroautophagy Nucleotide Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process Developmental Process Involved In Reproduction Organ Growth Zygotic Genome Activation Regulation Of Ornithine Metabolic Process Neuropeptide Processing ANPR-A Receptor Complex Vestibulocochlear Nerve Maturation Negative Regulation Of Store-operated Calcium Channel Activity Purine-containing Compound Biosynthetic Process Regulation Of Hormone Levels
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