NPPA and RORB

Number of citations of the paper that reports this interaction (PubMedID 15604093)
0

Data Source:
HPRD (two hybrid)

		NPPA	RORB
Description		natriuretic peptide A	RAR related orphan receptor B
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Brush Border Protein-containing Complex Mast Cell Granule Cell Projection Perikaryon Perinuclear Region Of Cytoplasm Glycinergic Synapse	Chromatin Nucleus Nucleoplasm
	Molecular Function	Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Guanylate Cyclase Activator Activity Hormone Receptor Binding Neuropeptide Receptor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Melatonin Receptor Activity Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Response To Hypoxia System Process Negative Regulation Of Systemic Arterial Blood Pressure Cardiac Conduction System Development Aortic Valve Morphogenesis CGMP Biosynthetic Process Protein Folding Receptor Guanylyl Cyclase Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Regulation Of Blood Pressure Positive Regulation Of Heart Rate Positive Regulation Of CGMP-mediated Signaling Cardiac Muscle Hypertrophy In Response To Stress CGMP-mediated Signaling Negative Regulation Of Cell Growth Response To Insulin Response To Muscle Stretch Sodium Ion Export Across Plasma Membrane Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vasodilation Regulation Of Vascular Permeability Negative Regulation Of JUN Kinase Activity Negative Regulation Of Blood Pressure Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Cardiac Muscle Contraction Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Hydrogen Peroxide Cellular Response To Mechanical Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Blood Vessel Diameter Maintenance Synaptic Signaling Via Neuropeptide Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Positive Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Collecting Lymphatic Vessel Constriction Cellular Response To Angiotensin Response To 3-methylcholanthrene	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II G Protein-coupled Receptor Signaling Pathway Visual Perception Regulation Of Gene Expression Intracellular Receptor Signaling Pathway Amacrine Cell Differentiation Eye Photoreceptor Cell Development Regulation Of Circadian Rhythm Negative Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Retinal Rod Cell Development Retinal Cone Cell Development Rhythmic Process Retina Development In Camera-type Eye Retinal Rod Cell Differentiation Cellular Response To Retinoic Acid
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Amyloid fiber formation	Nuclear Receptor transcription pathway Expression of BMAL (ARNTL), CLOCK, and NPAS2
Drugs			Melatonin
Diseases		Atrial fibrillation
GWAS		Atrial fibrillation ( 19597492) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Midregional pro atrial natriuretic peptide levels ( 29237677) Psoriasis ( 25854761) Pulse pressure ( 30578418) Systolic blood pressure ( 19430483 30578418) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tuberculosis ( 29036319)	Advanced age-related macular degeneration ( 26691988) Alcohol consumption (drinks per week) ( 30643258) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) levels in Hashimoto's thyroiditis ( 30926877) Chronotype ( 30696823) Hyperopia ( 33830181) Immature fraction of reticulocytes ( 32888494) Low myopia vs hyperopia ( 33830181) Macular thickness ( 30535121) Refractive error ( 23396134 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		15 interacting genes: EPB41 ESR1 HNF4A HSF2BP KAZN MAGEA12 MME NPR1 NPR2 NPR3 NR5A2 RORB UBQLN1 UBQLN2 UBQLN4	36 interacting genes: ANKS1A CLOCK CRACR2A CSNK2B DELEC1 FBXO7 GAS2L2 KRTAP4-5 LCK LCOR MAP6 MED25 MID2 MTCL2 NCOA1 NCOA6 NME1 NME2 NPPA NRIP1 NRIP2 NSD1 PNRC1 PNRC2 PSMC4 PSMC5 RORC SCNM1 SMARCD1 TEKT5 TLE5 TNNI2 TSGA10IP UBE2I ZNF417 ZNF587
Entrez ID		4878	6096
HPRD ID		00164	09062
Ensembl ID		ENSG00000175206	ENSG00000198963
Uniprot IDs		P01160	A0A1L4FMK7 Q58EY0 Q92753
PDB IDs		1ANP 1YK0 3N57 7BRH 7BRJ 7BRK 8TG9 9BCQ
Enriched GO Terms of Interacting Partners?		Natriuretic Peptide Receptor Activity Nuclear Receptor Activity CGMP Biosynthetic Process Hormone Binding CGMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Peptide Hormone Binding Polyubiquitin Modification-dependent Protein Binding Cyclic Purine Nucleotide Metabolic Process Guanylate Cyclase Activity Intracellular Receptor Signaling Pathway Positive Regulation Of Urine Volume Receptor Guanylyl Cyclase Signaling Pathway Autophagosome Rhythmic Process Nucleobase-containing Compound Biosynthetic Process Female Genitalia Development Positive Regulation Of ERAD Pathway Phosphorus-oxygen Lyase Activity Regulation Of Urine Volume Purine Ribonucleotide Biosynthetic Process Regulation Of ERAD Pathway Peptide Binding Ribose Phosphate Biosynthetic Process Protein-containing Complex Ovulation Cycle Process Sequence-specific DNA Binding Transcription Coregulator Binding Genitalia Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Blood Pressure Purine Nucleotide Biosynthetic Process Blood Circulation G Protein-coupled Peptide Receptor Activity Vacuole Organization Blood Vessel Remodeling Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Macroautophagy Nucleotide Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process Developmental Process Involved In Reproduction Organ Growth Zygotic Genome Activation Regulation Of Ornithine Metabolic Process Neuropeptide Processing ANPR-A Receptor Complex Vestibulocochlear Nerve Maturation Negative Regulation Of Store-operated Calcium Channel Activity Purine-containing Compound Biosynthetic Process Regulation Of Hormone Levels	Nuclear Retinoid X Receptor Binding Nuclear Estrogen Receptor Binding Nuclear Retinoic Acid Receptor Binding Regulation Of Metabolic Process ITP Biosynthetic Process Protein Histidine Kinase Activity Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process ITP Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Proteasome-activating Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Nucleus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process UTP Biosynthetic Process Nuclear Receptor Binding Regulation Of Macromolecule Biosynthetic Process GTP Biosynthetic Process UTP Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Signaling Receptor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process CTP Biosynthetic Process Proteasome Regulatory Particle, Base Subcomplex Negative Regulation Of Macromolecule Biosynthetic Process CTP Metabolic Process Transcription Coactivator Activity Nucleoside Diphosphate Kinase Activity Circadian Regulation Of Gene Expression Protein Localization To Microtubule Positive Regulation Of Nucleobase-containing Compound Metabolic Process Proteasome Accessory Complex Negative Regulation Of Transcription By RNA Polymerase II Transcription Factor Binding Positive Regulation Of Circadian Rhythm GTP Metabolic Process Transcription Corepressor Activity Pyrimidine Ribonucleotide Biosynthetic Process Macromolecule Catabolic Process
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