NOTCH4 and FBXW7

Number of citations of the paper that reports this interaction (PubMedID 11585921)
47

Data Source:
HPRD (in vivo)

		NOTCH4	FBXW7
Description		notch receptor 4	F-box and WD repeat domain containing 7
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Surface Membrane	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Protein-containing Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
	Molecular Function	Transcription Coactivator Activity Notch Binding Calcium Ion Binding Protein Binding Signaling Receptor Activity	Protein Binding Cyclin Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Binding Phosphothreonine Residue Binding Ubiquitin-protein Transferase Activator Activity Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Luteolysis Branching Involved In Blood Vessel Morphogenesis Cell Fate Determination Morphogenesis Of A Branching Structure Epithelial To Mesenchymal Transition Endothelial Cell Morphogenesis Vasculature Development Regulation Of DNA-templated Transcription Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Tissue Development Hemopoiesis Cell Differentiation Mammary Gland Development Endothelial Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Development Regulation Of Developmental Process Positive Regulation Of Developmental Process Positive Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin	G1/S Transition Of Mitotic Cell Cycle Vasculature Development DNA Repair DNA Damage Response Sister Chromatid Cohesion Regulation Of Mitotic Cell Cycle Negative Regulation Of Gene Expression Negative Regulation Of Triglyceride Biosynthetic Process Regulation Of Lipid Storage Ubiquitin Recycling Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Cellular Response To UV Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Protein Stabilization Lipid Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Mitophagy Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Osteoclast Development
Pathways		Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling Negative regulation of NOTCH4 signaling	Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		A body shape index ( 34021172) Age-related macular degeneration ( 22694956) Aspartate aminotransferase levels ( 29403010) Asthma ( 21804548 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Blood protein levels in cardiovascular risk ( 28369058) Chronic hepatitis B infection ( 25802187) Circulating myeloperoxidase levels (serum) ( 23620142) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Colorectal cancer ( 30529582) Crohn's disease ( 23266558) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Femur bone mineral density x serum urate levels interaction ( 34046847) Food antigen IgG levels ( 24962563) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) Hip circumference adjusted for BMI ( 34021172) HIV-1 control ( 20041166) Inflammatory bowel disease ( 28067908) Iron status biomarkers (iron levels) ( 28334935) Joint mobility (Beighton score) ( 27182965) Longevity ( 30294719) Lung cancer ( 31577861 28604730) Lung cancer in ever smokers ( 28604730) Lupus nephritis in systemic lupus erythematosus ( 24925725) Migraine ( 27322543) Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection ( 25030430) Obesity-related traits ( 23251661) Objective response to lithium treatment in bipolar disorder ( 26503763) Prostate cancer ( 23535732) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Schizophrenia ( 23894747 19571808 30285260) Soluble receptor for advanced glycation end-product levels ( 26083729) Squamous cell lung carcinoma ( 28604730) Systemic lupus erythematosus ( 32771030 21408207) Systemic sclerosis ( 21779181) Takayasu arteritis ( 25604533) Type 1 diabetes (age at diagnosis) ( 33179336) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 28067908 24837172) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)	Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494)
Interacting Genes		22 interacting genes: DLL4 EGFL7 ELOC FBXW7 MAML1 MAML2 MAML3 MSH5 NEU1 NFKBIL1 NFYA PBX2 PSEN1 PSEN2 PSMB8 RBPJ SLC27A4 SMAD2 SMAD3 SMAD4 TDP2 WWP2	84 interacting genes: ACD AHSG AKT1 ANGPTL4 ANP32B ARL6IP1 BCAS3 BEX1 BLM CCDC6 CCNE1 CCNE2 CDC34 CEBPD CUL1 DISC1 DVL1 DYRK2 EBNA1BP2 EXT1 EZH2 FANCC FBP2 FBXO45 GALNT12 GATA2 GATA3 GFI1 GLMN HEMGN HEY1 HIPK2 HNRNPK HRAS IGFBP3 IL24 JUN KLF10 KLF5 LINGO1 MALAT1 MAP2K1 MAPK3 MMS22L MYB MYC MYCN NANS NIP7 NOTCH1 NOTCH4 NOX1 PLK1 PPARGC1A PPP3R2 PRKN PSEN1 RFLNA SCGB3A1 SEC61B SHC1 SHOC2 SHPRH SIK2 SKP1 SMAD1 SNCA SP7 SPI1 STAT3 STAT5A STOML1 STYX SUMF2 TGFB1 TMOD1 TRIP12 TSC22D4 USP2 WDR5 WDR97 XPA YAP1 ZNF510
Entrez ID		4855	55294
HPRD ID		01290	05888
Ensembl ID		ENSG00000204301	ENSG00000109670
Uniprot IDs		A0A1U9X983 Q99466	G0Z2K0 Q969H0 S4R3U4
PDB IDs		7OR3 7OR5 7OR7	2OVP 2OVQ 2OVR 5IBK 5V4B 7T1Y 7T1Z
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process SMAD Protein Complex Positive Regulation Of Transcription By RNA Polymerase II Heteromeric SMAD Protein Complex Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regionalization I-SMAD Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Blood Vessel Lumenization Anterior/posterior Pattern Specification Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding MAML1-RBP-Jkappa- ICN1 Complex Activin Responsive Factor Complex SMAD Protein Signal Transduction Paraxial Mesoderm Morphogenesis R-SMAD Binding Regulation Of Notch Signaling Pathway Activin Receptor Signaling Pathway Pattern Specification Process Tissue Morphogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Endoderm Development Positive Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway Transcription Regulator Complex Epithelial Tube Morphogenesis Embryonic Morphogenesis Regulation Of Gene Expression Mesoderm Morphogenesis Regulation Of Macromolecule Biosynthetic Process Neuron Fate Commitment Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Primary Metabolic Process Negative Regulation Of Ossification Pericardium Development Aspartic Endopeptidase Activity, Intramembrane Cleaving Negative Regulation Of Macromolecule Biosynthetic Process Ventricular Cardiac Muscle Tissue Morphogenesis	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MiRNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of MiRNA Transcription Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Metabolic Process Cellular Response To Stress Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Developmental Process Negative Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Developmental Process Cell Population Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Metabolic Process Gland Development Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Multicellular Organismal Development Regulation Of Apoptotic Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Differentiation Negative Regulation Of Developmental Process Negative Regulation Of Apoptotic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cell Differentiation Apoptotic Process Regulation Of Multicellular Organismal Process
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