FBXW7 and BCAS3

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		FBXW7	BCAS3
Description		F-box and WD repeat domain containing 7	BCAS3 microtubule associated cell migration factor
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Protein-containing Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex	Phagophore Assembly Site Euchromatin Nucleus Cytoplasm Cytoskeleton Cytoplasmic Microtubule Cell Leading Edge Intermediate Filament Cytoskeleton
	Molecular Function	Protein Binding Cyclin Binding Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Binding Phosphothreonine Residue Binding Ubiquitin-protein Transferase Activator Activity Ubiquitin-like Ligase-substrate Adaptor Activity	Chromatin Binding Protein Binding Acetyltransferase Activator Activity Nuclear Receptor Binding Histone Acetyltransferase Binding Phosphatidylinositol Binding Histone Binding Beta-tubulin Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Vasculature Development DNA Repair DNA Damage Response Sister Chromatid Cohesion Regulation Of Mitotic Cell Cycle Negative Regulation Of Gene Expression Negative Regulation Of Triglyceride Biosynthetic Process Regulation Of Lipid Storage Ubiquitin Recycling Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Cellular Response To UV Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Protein Stabilization Lipid Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Mitophagy Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Hepatocyte Proliferation Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Osteoclast Development	Angiogenesis Autophagy Cell-cell Signaling Positive Regulation Of Endothelial Cell Migration Regulation Of Actin Cytoskeleton Organization Response To Starvation Positive Regulation Of Catalytic Activity Response To Estrogen Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Estrogen Stimulus
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494)	Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Alzheimer's disease (cognitive decline) ( 23535033) Blood urea nitrogen levels ( 31152163 29403010) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Calcium levels ( 29403010) Chronic kidney disease ( 20383146 31152163) Coronary artery disease ( 33020668 29212778 26343387 32469254) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766 31451708 29779033 31152163) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) FEV1 ( 30804560) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Gout ( 25967671 32238385) Gout (combined type) ( 32238385) Heel bone mineral density ( 28869591 30598549) Height ( 18391951) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Immune reponse to smallpox (secreted IL-2) ( 22610502) Intraocular pressure ( 31959993 29785010 30054594 29617998) Lung function (FEV1/FVC) ( 30804560) Macular thickness ( 30535121) Medial orbital frontal cortex volume ( 31530798) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Myocardial infarction ( 33532862 26343387) Obesity-related traits ( 23251661) Optic cup area ( 28073927 25631615 31798171) Optic disc size ( 31809533) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30578418) Red blood cell count ( 27863252 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278) Renal function-related traits (BUN) ( 22797727) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727) Serum creatinine levels ( 29779033) Serum uric acid levels ( 29403010 30993211 32514006) Systolic blood pressure ( 30578418 30224653) Thyroid stimulating hormone levels ( 32769997 30367059) Urate levels ( 31985003 31578528 23263486) Urolithiasis ( 30975718) Vertical cup-disc ratio ( 20548946) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Vitamin C levels ( 33203707) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		84 interacting genes: ACD AHSG AKT1 ANGPTL4 ANP32B ARL6IP1 BCAS3 BEX1 BLM CCDC6 CCNE1 CCNE2 CDC34 CEBPD CUL1 DISC1 DVL1 DYRK2 EBNA1BP2 EXT1 EZH2 FANCC FBP2 FBXO45 GALNT12 GATA2 GATA3 GFI1 GLMN HEMGN HEY1 HIPK2 HNRNPK HRAS IGFBP3 IL24 JUN KLF10 KLF5 LINGO1 MALAT1 MAP2K1 MAPK3 MMS22L MYB MYC MYCN NANS NIP7 NOTCH1 NOTCH4 NOX1 PLK1 PPARGC1A PPP3R2 PRKN PSEN1 RFLNA SCGB3A1 SEC61B SHC1 SHOC2 SHPRH SIK2 SKP1 SMAD1 SNCA SP7 SPI1 STAT3 STAT5A STOML1 STYX SUMF2 TGFB1 TMOD1 TRIP12 TSC22D4 USP2 WDR5 WDR97 XPA YAP1 ZNF510	23 interacting genes: ATM BAG4 CCND1 CDC23 CTBP1 CTBP2 DDB1 FBXW7 H3C1 KRAS MTDH PALB2 PELP1 PHB1 PLEKHF2 PTPN1 SMAD4 STK11 TGFB1 TP53 TSG101 XRCC3 ZDHHC17
Entrez ID		55294	54828
HPRD ID		05888	06313
Ensembl ID		ENSG00000109670	ENSG00000141376
Uniprot IDs		G0Z2K0 Q969H0 S4R3U4	Q05D99 Q9H6U6
PDB IDs		2OVP 2OVQ 2OVR 5IBK 5V4B 7T1Y 7T1Z
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MiRNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of MiRNA Transcription Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Metabolic Process Cellular Response To Stress Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Developmental Process Negative Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Developmental Process Cell Population Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Metabolic Process Gland Development Regulation Of Cell Population Proliferation Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Multicellular Organismal Development Regulation Of Apoptotic Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Differentiation Negative Regulation Of Developmental Process Negative Regulation Of Apoptotic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cell Differentiation Apoptotic Process Regulation Of Multicellular Organismal Process	Protein-containing Complex Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Negative Regulation Of Cell Population Proliferation Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Apoptotic Process Regulation Of Cell Population Proliferation Regulation Of Cell Cycle Regulation Of Signal Transduction Regulation Of Cell Cycle Phase Transition Response To Radiation Cellular Response To Radiation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Communication Regulation Of Signaling Regulation Of Neuron Apoptotic Process Macromolecule Metabolic Process Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Response To Ionizing Radiation Viral Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Transcription Repressor Complex Regulation Of ERK1 And ERK2 Cascade Response To UV Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Growth Regulation Of Cell Cycle Process Response To Light Stimulus Positive Regulation Of Apoptotic Process Negative Regulation Of Macromolecule Metabolic Process DNA Damage Response Positive Regulation Of Programmed Cell Death Negative Regulation Of RNA Metabolic Process Cellular Response To UV Response To X-ray Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Transcription Corepressor Activity Developmental Growth Negative Regulation Of Apoptotic Process Negative Regulation Of Growth Regulation Of Cell Growth Cellular Response To Light Stimulus
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